Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Cardiologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000800188 |
Resumo: | Abstract Background: Left ventricular global longitudinal strain value (GLS) can predict functional capacity in patients with preserved left ventricular ejection fraction (LVEF) heart failure (HF) and to assess prognosis in reduced LVEF HF. Objetive: Correlate GLS with parameters of Cardiopulmonary Exercise Test (CPET) and to assess if they could predict systolic HF patients that are more appropriated to be referred to heart transplantation according to CPET criteria. Methods: Systolic HF patients with LVEF < 45%, NYHA functional class II and III, underwent prospectively CPET and echocardiography with strain analysis. LVEF and GLS were correlated with the following CPET variables: maxVO2, VE/VCO2 slope, heart rate reduction during the first minute of recovery (HRR) and time needed to reduce maxVO2 in 50% after physical exercise (T1/2VO2). ROC curve analysis of GLS to predict VO2 < 14 mL/kg/min and VE/VCO2 slope > 35 (heart transplantation’s criteria) was performed. Results: Twenty six patients were selected (age, 47 ± 12 years, 58% men, mean LVEF = 28 ± 8%). LVEF correlated only with maxVO2 and T1/2VO2. GLS correlated to all CPET variables (maxVO2: r = 0.671, p = 0.001; VE/VCO2 slope: r = -0.513, p = 0.007; HRR: r = 0.466, p = 0.016, and T1/2VO2: r = -0.696, p = 0.001). GLS area under the ROC curve to predict heart transplantation’s criteria was 0.88 (sensitivity 75%, specificity 83%) for a cut-off value of -5.7%, p = 0.03. Conclusion: GLS was significantly associated with all functional CPET parameters. It could classify HF patients according to the functional capacity and may stratify which patients have a poor prognosis and therefore to deserve more differentiated treatment, such as heart transplantation. |
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Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart FailureHeart FailureLongitudinal StrainTorsion, MechanicalTorsion AbnormalityVentricular Dysfunction, LeftEchocardiography, Doppler/methodsAbstract Background: Left ventricular global longitudinal strain value (GLS) can predict functional capacity in patients with preserved left ventricular ejection fraction (LVEF) heart failure (HF) and to assess prognosis in reduced LVEF HF. Objetive: Correlate GLS with parameters of Cardiopulmonary Exercise Test (CPET) and to assess if they could predict systolic HF patients that are more appropriated to be referred to heart transplantation according to CPET criteria. Methods: Systolic HF patients with LVEF < 45%, NYHA functional class II and III, underwent prospectively CPET and echocardiography with strain analysis. LVEF and GLS were correlated with the following CPET variables: maxVO2, VE/VCO2 slope, heart rate reduction during the first minute of recovery (HRR) and time needed to reduce maxVO2 in 50% after physical exercise (T1/2VO2). ROC curve analysis of GLS to predict VO2 < 14 mL/kg/min and VE/VCO2 slope > 35 (heart transplantation’s criteria) was performed. Results: Twenty six patients were selected (age, 47 ± 12 years, 58% men, mean LVEF = 28 ± 8%). LVEF correlated only with maxVO2 and T1/2VO2. GLS correlated to all CPET variables (maxVO2: r = 0.671, p = 0.001; VE/VCO2 slope: r = -0.513, p = 0.007; HRR: r = 0.466, p = 0.016, and T1/2VO2: r = -0.696, p = 0.001). GLS area under the ROC curve to predict heart transplantation’s criteria was 0.88 (sensitivity 75%, specificity 83%) for a cut-off value of -5.7%, p = 0.03. Conclusion: GLS was significantly associated with all functional CPET parameters. It could classify HF patients according to the functional capacity and may stratify which patients have a poor prognosis and therefore to deserve more differentiated treatment, such as heart transplantation.Sociedade Brasileira de Cardiologia - SBC2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000800188Arquivos Brasileiros de Cardiologia v.113 n.2 2019reponame:Arquivos Brasileiros de Cardiologia (Online)instname:Sociedade Brasileira de Cardiologia (SBC)instacron:SBC10.5935/abc.20190119info:eu-repo/semantics/openAccessMaia,Rafael José CoelhoBrandão,Simone Cristina SoaresLeite,JéssicaParente,Giordano BrunoPinheiro,FilipeAraújo,Bruna Thays SantanaAguiar,Maria Inês RemígioMartins,Sílvia MarinhoBrandão,Daniella CunhaAndrade,Armele Dornelas deeng2019-08-28T00:00:00Zoai:scielo:S0066-782X2019000800188Revistahttp://www.arquivosonline.com.br/https://old.scielo.br/oai/scielo-oai.php||arquivos@cardiol.br1678-41700066-782Xopendoar:2019-08-28T00:00Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC)false |
dc.title.none.fl_str_mv |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
title |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
spellingShingle |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure Maia,Rafael José Coelho Heart Failure Longitudinal Strain Torsion, Mechanical Torsion Abnormality Ventricular Dysfunction, Left Echocardiography, Doppler/methods |
title_short |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
title_full |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
title_fullStr |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
title_full_unstemmed |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
title_sort |
Global Longitudinal Strain Predicts Poor Functional Capacity in Patients with Systolic Heart Failure |
author |
Maia,Rafael José Coelho |
author_facet |
Maia,Rafael José Coelho Brandão,Simone Cristina Soares Leite,Jéssica Parente,Giordano Bruno Pinheiro,Filipe Araújo,Bruna Thays Santana Aguiar,Maria Inês Remígio Martins,Sílvia Marinho Brandão,Daniella Cunha Andrade,Armele Dornelas de |
author_role |
author |
author2 |
Brandão,Simone Cristina Soares Leite,Jéssica Parente,Giordano Bruno Pinheiro,Filipe Araújo,Bruna Thays Santana Aguiar,Maria Inês Remígio Martins,Sílvia Marinho Brandão,Daniella Cunha Andrade,Armele Dornelas de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maia,Rafael José Coelho Brandão,Simone Cristina Soares Leite,Jéssica Parente,Giordano Bruno Pinheiro,Filipe Araújo,Bruna Thays Santana Aguiar,Maria Inês Remígio Martins,Sílvia Marinho Brandão,Daniella Cunha Andrade,Armele Dornelas de |
dc.subject.por.fl_str_mv |
Heart Failure Longitudinal Strain Torsion, Mechanical Torsion Abnormality Ventricular Dysfunction, Left Echocardiography, Doppler/methods |
topic |
Heart Failure Longitudinal Strain Torsion, Mechanical Torsion Abnormality Ventricular Dysfunction, Left Echocardiography, Doppler/methods |
description |
Abstract Background: Left ventricular global longitudinal strain value (GLS) can predict functional capacity in patients with preserved left ventricular ejection fraction (LVEF) heart failure (HF) and to assess prognosis in reduced LVEF HF. Objetive: Correlate GLS with parameters of Cardiopulmonary Exercise Test (CPET) and to assess if they could predict systolic HF patients that are more appropriated to be referred to heart transplantation according to CPET criteria. Methods: Systolic HF patients with LVEF < 45%, NYHA functional class II and III, underwent prospectively CPET and echocardiography with strain analysis. LVEF and GLS were correlated with the following CPET variables: maxVO2, VE/VCO2 slope, heart rate reduction during the first minute of recovery (HRR) and time needed to reduce maxVO2 in 50% after physical exercise (T1/2VO2). ROC curve analysis of GLS to predict VO2 < 14 mL/kg/min and VE/VCO2 slope > 35 (heart transplantation’s criteria) was performed. Results: Twenty six patients were selected (age, 47 ± 12 years, 58% men, mean LVEF = 28 ± 8%). LVEF correlated only with maxVO2 and T1/2VO2. GLS correlated to all CPET variables (maxVO2: r = 0.671, p = 0.001; VE/VCO2 slope: r = -0.513, p = 0.007; HRR: r = 0.466, p = 0.016, and T1/2VO2: r = -0.696, p = 0.001). GLS area under the ROC curve to predict heart transplantation’s criteria was 0.88 (sensitivity 75%, specificity 83%) for a cut-off value of -5.7%, p = 0.03. Conclusion: GLS was significantly associated with all functional CPET parameters. It could classify HF patients according to the functional capacity and may stratify which patients have a poor prognosis and therefore to deserve more differentiated treatment, such as heart transplantation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000800188 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019000800188 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/abc.20190119 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia v.113 n.2 2019 reponame:Arquivos Brasileiros de Cardiologia (Online) instname:Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
instname_str |
Sociedade Brasileira de Cardiologia (SBC) |
instacron_str |
SBC |
institution |
SBC |
reponame_str |
Arquivos Brasileiros de Cardiologia (Online) |
collection |
Arquivos Brasileiros de Cardiologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Cardiologia (Online) - Sociedade Brasileira de Cardiologia (SBC) |
repository.mail.fl_str_mv |
||arquivos@cardiol.br |
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1752126569710616576 |