Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion

Detalhes bibliográficos
Autor(a) principal: Urt Filho,Antônio
Data de Publicação: 2012
Outros Autores: Inouye,Celso Massaschi, Pontes,José Carlos Dorsa Vieira, Silva,Andréia Conceição Brochado Antoniolli, Silva,Guilherme Viotto Rodrigues da, Santos,Carlos Henrique Marques dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Acta Cirúrgica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200013
Resumo: PURPOSE: To evaluate the effects of propofol as an inhibitor of tissue injury in testicular ischemia-reperfusion in rats. METHODS: 30 Wistar rats were assigned to one of three groups of 10 animals: G1, testicular exposure alone; G2 and G3: testicular ischemia caused by left spermatic cord torsion of 720º. In G3, propofol was administered intraperitoneally at 20 mg/kg/h 45 minutes after spermatic cord torsion. In G2 and G3, spermatic cords were detorsioned after 60 min. In all three groups, testes were subsequently repositioned in the scrotum. After 90 days, bilateral orchiectomy was performed for histological examination. RESULTS: No abnormalities in seminiferous tubules were found in G1. In G2, 86.6% of left testes exhibited abnormalities, in contrast with 67.8% for right testes. In G3, these proportions were 57.3% and 45.6%, respectively. A statistically significant difference was found between G2 and G3. CONCLUSION: Propofol reduced the tissue damage in rat testes subjected to ischemia-reperfusion caused by spermatic cord torsion.
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spelling Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusionPropofolTestisIschemiaReperfusionRatsPURPOSE: To evaluate the effects of propofol as an inhibitor of tissue injury in testicular ischemia-reperfusion in rats. METHODS: 30 Wistar rats were assigned to one of three groups of 10 animals: G1, testicular exposure alone; G2 and G3: testicular ischemia caused by left spermatic cord torsion of 720º. In G3, propofol was administered intraperitoneally at 20 mg/kg/h 45 minutes after spermatic cord torsion. In G2 and G3, spermatic cords were detorsioned after 60 min. In all three groups, testes were subsequently repositioned in the scrotum. After 90 days, bilateral orchiectomy was performed for histological examination. RESULTS: No abnormalities in seminiferous tubules were found in G1. In G2, 86.6% of left testes exhibited abnormalities, in contrast with 67.8% for right testes. In G3, these proportions were 57.3% and 45.6%, respectively. A statistically significant difference was found between G2 and G3. CONCLUSION: Propofol reduced the tissue damage in rat testes subjected to ischemia-reperfusion caused by spermatic cord torsion.Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200013Acta Cirúrgica Brasileira v.27 n.2 2012reponame:Acta Cirúrgica Brasileira (Online)instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)instacron:SBDPC10.1590/S0102-86502012000200013info:eu-repo/semantics/openAccessUrt Filho,AntônioInouye,Celso MassaschiPontes,José Carlos Dorsa VieiraSilva,Andréia Conceição Brochado AntoniolliSilva,Guilherme Viotto Rodrigues daSantos,Carlos Henrique Marques doseng2012-02-27T00:00:00Zoai:scielo:S0102-86502012000200013Revistahttps://www.bvs-vet.org.br/vetindex/periodicos/acta-cirurgica-brasileira/https://old.scielo.br/oai/scielo-oai.php||sgolden@terra.com.br0102-86501678-2674opendoar:2012-02-27T00:00Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)false
dc.title.none.fl_str_mv Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
title Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
spellingShingle Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
Urt Filho,Antônio
Propofol
Testis
Ischemia
Reperfusion
Rats
title_short Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
title_full Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
title_fullStr Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
title_full_unstemmed Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
title_sort Propofol effects on the morphology of rat testes subjected to testicular ischemia­reperfusion
author Urt Filho,Antônio
author_facet Urt Filho,Antônio
Inouye,Celso Massaschi
Pontes,José Carlos Dorsa Vieira
Silva,Andréia Conceição Brochado Antoniolli
Silva,Guilherme Viotto Rodrigues da
Santos,Carlos Henrique Marques dos
author_role author
author2 Inouye,Celso Massaschi
Pontes,José Carlos Dorsa Vieira
Silva,Andréia Conceição Brochado Antoniolli
Silva,Guilherme Viotto Rodrigues da
Santos,Carlos Henrique Marques dos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Urt Filho,Antônio
Inouye,Celso Massaschi
Pontes,José Carlos Dorsa Vieira
Silva,Andréia Conceição Brochado Antoniolli
Silva,Guilherme Viotto Rodrigues da
Santos,Carlos Henrique Marques dos
dc.subject.por.fl_str_mv Propofol
Testis
Ischemia
Reperfusion
Rats
topic Propofol
Testis
Ischemia
Reperfusion
Rats
description PURPOSE: To evaluate the effects of propofol as an inhibitor of tissue injury in testicular ischemia-reperfusion in rats. METHODS: 30 Wistar rats were assigned to one of three groups of 10 animals: G1, testicular exposure alone; G2 and G3: testicular ischemia caused by left spermatic cord torsion of 720º. In G3, propofol was administered intraperitoneally at 20 mg/kg/h 45 minutes after spermatic cord torsion. In G2 and G3, spermatic cords were detorsioned after 60 min. In all three groups, testes were subsequently repositioned in the scrotum. After 90 days, bilateral orchiectomy was performed for histological examination. RESULTS: No abnormalities in seminiferous tubules were found in G1. In G2, 86.6% of left testes exhibited abnormalities, in contrast with 67.8% for right testes. In G3, these proportions were 57.3% and 45.6%, respectively. A statistically significant difference was found between G2 and G3. CONCLUSION: Propofol reduced the tissue damage in rat testes subjected to ischemia-reperfusion caused by spermatic cord torsion.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-86502012000200013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv Acta Cirúrgica Brasileira v.27 n.2 2012
reponame:Acta Cirúrgica Brasileira (Online)
instname:Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron:SBDPC
instname_str Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
instacron_str SBDPC
institution SBDPC
reponame_str Acta Cirúrgica Brasileira (Online)
collection Acta Cirúrgica Brasileira (Online)
repository.name.fl_str_mv Acta Cirúrgica Brasileira (Online) - Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC)
repository.mail.fl_str_mv ||sgolden@terra.com.br
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