Osteocalcin, energy and glucose metabolism

Detalhes bibliográficos
Autor(a) principal: Zanatta,Leila C. B.
Data de Publicação: 2014
Outros Autores: Boguszewski,Cesar L., Borba,Victoria Z. C., Kulak,Carolina A. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500444
Resumo: Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome.
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spelling Osteocalcin, energy and glucose metabolismOsteocalcinundercarboxylated osteocalcinmetabolic syndromeglucoseenergy metabolismdiabetesobesityleptininsulinadiponectinOsteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome.Sociedade Brasileira de Endocrinologia e Metabologia2014-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500444Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.5 2014reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/0004-2730000003333info:eu-repo/semantics/openAccessZanatta,Leila C. B.Boguszewski,Cesar L.Borba,Victoria Z. C.Kulak,Carolina A. M.eng2014-08-19T00:00:00Zoai:scielo:S0004-27302014000500444Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2014-08-19T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Osteocalcin, energy and glucose metabolism
title Osteocalcin, energy and glucose metabolism
spellingShingle Osteocalcin, energy and glucose metabolism
Zanatta,Leila C. B.
Osteocalcin
undercarboxylated osteocalcin
metabolic syndrome
glucose
energy metabolism
diabetes
obesity
leptin
insulin
adiponectin
title_short Osteocalcin, energy and glucose metabolism
title_full Osteocalcin, energy and glucose metabolism
title_fullStr Osteocalcin, energy and glucose metabolism
title_full_unstemmed Osteocalcin, energy and glucose metabolism
title_sort Osteocalcin, energy and glucose metabolism
author Zanatta,Leila C. B.
author_facet Zanatta,Leila C. B.
Boguszewski,Cesar L.
Borba,Victoria Z. C.
Kulak,Carolina A. M.
author_role author
author2 Boguszewski,Cesar L.
Borba,Victoria Z. C.
Kulak,Carolina A. M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Zanatta,Leila C. B.
Boguszewski,Cesar L.
Borba,Victoria Z. C.
Kulak,Carolina A. M.
dc.subject.por.fl_str_mv Osteocalcin
undercarboxylated osteocalcin
metabolic syndrome
glucose
energy metabolism
diabetes
obesity
leptin
insulin
adiponectin
topic Osteocalcin
undercarboxylated osteocalcin
metabolic syndrome
glucose
energy metabolism
diabetes
obesity
leptin
insulin
adiponectin
description Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on pancreatic beta cells and adipose tissue. Undercarboxylated osteocalcin is the hormonally active isoform and stimulates insulin secretion and enhances insulin sensitivity in adipose tissue and muscle. Insulin and leptin, in turn, act on bone tissue, modulating the osteocalcin secretion, in a traditional feedback mechanism that places the skeleton as a true endocrine organ. Further studies are required to elucidate the role of osteocalcin in the regulation of glucose and energy metabolism in humans and its potential therapeutic implications in diabetes, obesity and metabolic syndrome.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500444
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500444
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-2730000003333
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.5 2014
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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