Interval training attenuates the metabolic disturbances in type 1 diabetes rat model
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000800003 |
Resumo: | OBJECTIVE: This study investigated the effect of interval training on blood biochemistry and immune parameters in type 1 diabetic rats. MATERIALS AND METHODS: Male Wistar rats were divided into four groups: sedentary (SE, n = 15), interval training (IT, n = 17), diabetic sedentary (DSE, n = 17), diabetic interval training (DIT, n = 17). Diabetes was induced by i.v. injection of streptozotocin (60 mg/kg). Swimming Interval Training consisted of 30-s exercise with 30-s rest, for 30 minutes, during 6 weeks, four times a week, with an overload of 15% of body mass. Plasma glucose, lactate, triacylglycerol and total cholesterol concentrations, phagocytic capacity, cationic vesicle content, and superoxide anion and hydrogen peroxide production by blood neutrophils and peritoneal macrophages were evaluated. Proliferation of mesenteric lymphocytes was also estimated. RESULTS: Interval training resulted in attenuation of the resting hyperglycemic state and decreased blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DSE group. Interval training increased all functionality parameters of peritoneal macrophages in the IT group. Interval training also led to a twofold increase in the proliferation of mesenteric lymphocytes after 6 weeks of exercise in the DIT group. CONCLUSION: Low-volume high-intensity physical exercise attenuates hyperglycemia and dislipidemia induced by type 1 diabetes, and induces changes in the functionality of innate and acquired immunity. |
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Interval training attenuates the metabolic disturbances in type 1 diabetes rat modelInterval trainingdiabetes mellitusimmune systemhyperglycemiaOBJECTIVE: This study investigated the effect of interval training on blood biochemistry and immune parameters in type 1 diabetic rats. MATERIALS AND METHODS: Male Wistar rats were divided into four groups: sedentary (SE, n = 15), interval training (IT, n = 17), diabetic sedentary (DSE, n = 17), diabetic interval training (DIT, n = 17). Diabetes was induced by i.v. injection of streptozotocin (60 mg/kg). Swimming Interval Training consisted of 30-s exercise with 30-s rest, for 30 minutes, during 6 weeks, four times a week, with an overload of 15% of body mass. Plasma glucose, lactate, triacylglycerol and total cholesterol concentrations, phagocytic capacity, cationic vesicle content, and superoxide anion and hydrogen peroxide production by blood neutrophils and peritoneal macrophages were evaluated. Proliferation of mesenteric lymphocytes was also estimated. RESULTS: Interval training resulted in attenuation of the resting hyperglycemic state and decreased blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DSE group. Interval training increased all functionality parameters of peritoneal macrophages in the IT group. Interval training also led to a twofold increase in the proliferation of mesenteric lymphocytes after 6 weeks of exercise in the DIT group. CONCLUSION: Low-volume high-intensity physical exercise attenuates hyperglycemia and dislipidemia induced by type 1 diabetes, and induces changes in the functionality of innate and acquired immunity.Sociedade Brasileira de Endocrinologia e Metabologia2013-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000800003Arquivos Brasileiros de Endocrinologia & Metabologia v.57 n.8 2013reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302013000800003info:eu-repo/semantics/openAccessRocha,Ricelli Endrigo RuppelCoelho,IsabelaPequito,Daniela Cristina T.Yamagushi,AdrianaBorghetti,GinaYamazaki,Ricardo KeyBrito,Gleisson Alisson Pereira deMachado,JulianoKryczyk,MarceloNunes,Everson AraújoVenera,GracielaFernandes,Luiz Claudioeng2013-12-11T00:00:00Zoai:scielo:S0004-27302013000800003Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2013-12-11T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
title |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
spellingShingle |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model Rocha,Ricelli Endrigo Ruppel Interval training diabetes mellitus immune system hyperglycemia |
title_short |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
title_full |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
title_fullStr |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
title_full_unstemmed |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
title_sort |
Interval training attenuates the metabolic disturbances in type 1 diabetes rat model |
author |
Rocha,Ricelli Endrigo Ruppel |
author_facet |
Rocha,Ricelli Endrigo Ruppel Coelho,Isabela Pequito,Daniela Cristina T. Yamagushi,Adriana Borghetti,Gina Yamazaki,Ricardo Key Brito,Gleisson Alisson Pereira de Machado,Juliano Kryczyk,Marcelo Nunes,Everson Araújo Venera,Graciela Fernandes,Luiz Claudio |
author_role |
author |
author2 |
Coelho,Isabela Pequito,Daniela Cristina T. Yamagushi,Adriana Borghetti,Gina Yamazaki,Ricardo Key Brito,Gleisson Alisson Pereira de Machado,Juliano Kryczyk,Marcelo Nunes,Everson Araújo Venera,Graciela Fernandes,Luiz Claudio |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,Ricelli Endrigo Ruppel Coelho,Isabela Pequito,Daniela Cristina T. Yamagushi,Adriana Borghetti,Gina Yamazaki,Ricardo Key Brito,Gleisson Alisson Pereira de Machado,Juliano Kryczyk,Marcelo Nunes,Everson Araújo Venera,Graciela Fernandes,Luiz Claudio |
dc.subject.por.fl_str_mv |
Interval training diabetes mellitus immune system hyperglycemia |
topic |
Interval training diabetes mellitus immune system hyperglycemia |
description |
OBJECTIVE: This study investigated the effect of interval training on blood biochemistry and immune parameters in type 1 diabetic rats. MATERIALS AND METHODS: Male Wistar rats were divided into four groups: sedentary (SE, n = 15), interval training (IT, n = 17), diabetic sedentary (DSE, n = 17), diabetic interval training (DIT, n = 17). Diabetes was induced by i.v. injection of streptozotocin (60 mg/kg). Swimming Interval Training consisted of 30-s exercise with 30-s rest, for 30 minutes, during 6 weeks, four times a week, with an overload of 15% of body mass. Plasma glucose, lactate, triacylglycerol and total cholesterol concentrations, phagocytic capacity, cationic vesicle content, and superoxide anion and hydrogen peroxide production by blood neutrophils and peritoneal macrophages were evaluated. Proliferation of mesenteric lymphocytes was also estimated. RESULTS: Interval training resulted in attenuation of the resting hyperglycemic state and decreased blood lipids in the DIT group. Diabetes increased the functionality of blood neutrophils and peritoneal macrophages in the DSE group. Interval training increased all functionality parameters of peritoneal macrophages in the IT group. Interval training also led to a twofold increase in the proliferation of mesenteric lymphocytes after 6 weeks of exercise in the DIT group. CONCLUSION: Low-volume high-intensity physical exercise attenuates hyperglycemia and dislipidemia induced by type 1 diabetes, and induces changes in the functionality of innate and acquired immunity. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000800003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302013000800003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302013000800003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.57 n.8 2013 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734812564815872 |