Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams

Detalhes bibliográficos
Autor(a) principal: Spadotto,Raquel
Data de Publicação: 2012
Outros Autores: Damasceno,Débora Cristina, Godinho,Antonio Francisco, Amorim,Elaine Manoela Porto, Perobelli,Juliana Elaine, Kempinas,Wilma De Grava
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000200002
Resumo: OBJECTIVES: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. MATERIALS AND METHODS: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. RESULTS: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. CONCLUSIONS: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively.
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spelling Reproductive physiology, and physical and sexual development of female offspring born to diabetic damsSexual behaviorphysical developmentdiabetesfemale reproductive physiologyfemale ratstreptozotocinOBJECTIVES: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. MATERIALS AND METHODS: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. RESULTS: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. CONCLUSIONS: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively.Sociedade Brasileira de Endocrinologia e Metabologia2012-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000200002Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.2 2012reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302012000200002info:eu-repo/semantics/openAccessSpadotto,RaquelDamasceno,Débora CristinaGodinho,Antonio FranciscoAmorim,Elaine Manoela PortoPerobelli,Juliana ElaineKempinas,Wilma De Gravaeng2012-05-11T00:00:00Zoai:scielo:S0004-27302012000200002Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2012-05-11T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
title Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
spellingShingle Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
Spadotto,Raquel
Sexual behavior
physical development
diabetes
female reproductive physiology
female rat
streptozotocin
title_short Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
title_full Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
title_fullStr Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
title_full_unstemmed Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
title_sort Reproductive physiology, and physical and sexual development of female offspring born to diabetic dams
author Spadotto,Raquel
author_facet Spadotto,Raquel
Damasceno,Débora Cristina
Godinho,Antonio Francisco
Amorim,Elaine Manoela Porto
Perobelli,Juliana Elaine
Kempinas,Wilma De Grava
author_role author
author2 Damasceno,Débora Cristina
Godinho,Antonio Francisco
Amorim,Elaine Manoela Porto
Perobelli,Juliana Elaine
Kempinas,Wilma De Grava
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Spadotto,Raquel
Damasceno,Débora Cristina
Godinho,Antonio Francisco
Amorim,Elaine Manoela Porto
Perobelli,Juliana Elaine
Kempinas,Wilma De Grava
dc.subject.por.fl_str_mv Sexual behavior
physical development
diabetes
female reproductive physiology
female rat
streptozotocin
topic Sexual behavior
physical development
diabetes
female reproductive physiology
female rat
streptozotocin
description OBJECTIVES: The objective of this study was to evaluate physical and sexual development and reproductive physiology in female rat offspring that developed in hyperglycemia conditions in utero and during lactation. MATERIALS AND METHODS: Maternal diabetes was induced in female rats by a single IV injection of streptozotocin before mating. Female offspring development was evaluated by means of the following parameters: physical development; age of vaginal opening and first estrus; weight and histological evaluation of uterus and ovaries; duration of the estrous cycle, sexual behavior, and fertility after natural mating. RESULTS: In the female offspring, maternal diabetes caused delays in initial physical development; diminution in ovary weight and number of follicles; and inferior reproductive performance compared with the control group. CONCLUSIONS: The exposure to hyperglycemia in uterus and during lactation caused delays in physical and sexual development, and affected the reproductive physiology of female rats negatively.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000200002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302012000200002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.2 2012
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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