Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study
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Publication Date: | 2014 |
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Format: | Article |
Language: | eng |
Source: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000600640 |
Summary: | Objective: The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population. Subjects and methods: A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform. Results: Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group. Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population. |
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Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control studyAutoimmune thyroid disease (AITD)Graves? disease (GD)Hashimoto?s thyroiditis (HT)ubiquitin associated and SH3 domain containing A (UBASH3A)single nucleotide polymorphism (SNP) Objective: The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population. Subjects and methods: A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform. Results: Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group. Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population. Sociedade Brasileira de Endocrinologia e Metabologia2014-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000600640Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.6 2014reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/0004-2730000003209info:eu-repo/semantics/openAccessCai,TianTianWang,XuanMuhali,Fatuma-SaidSong,RongHuaShi,XiaoHongJiang,WenJuanXiao,LingLi,DanFengZhang,JinAneng2014-09-04T00:00:00Zoai:scielo:S0004-27302014000600640Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2014-09-04T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
title |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
spellingShingle |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study Cai,TianTian Autoimmune thyroid disease (AITD) Graves? disease (GD) Hashimoto?s thyroiditis (HT) ubiquitin associated and SH3 domain containing A (UBASH3A) single nucleotide polymorphism (SNP) |
title_short |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
title_full |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
title_fullStr |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
title_full_unstemmed |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
title_sort |
Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study |
author |
Cai,TianTian |
author_facet |
Cai,TianTian Wang,Xuan Muhali,Fatuma-Said Song,RongHua Shi,XiaoHong Jiang,WenJuan Xiao,Ling Li,DanFeng Zhang,JinAn |
author_role |
author |
author2 |
Wang,Xuan Muhali,Fatuma-Said Song,RongHua Shi,XiaoHong Jiang,WenJuan Xiao,Ling Li,DanFeng Zhang,JinAn |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cai,TianTian Wang,Xuan Muhali,Fatuma-Said Song,RongHua Shi,XiaoHong Jiang,WenJuan Xiao,Ling Li,DanFeng Zhang,JinAn |
dc.subject.por.fl_str_mv |
Autoimmune thyroid disease (AITD) Graves? disease (GD) Hashimoto?s thyroiditis (HT) ubiquitin associated and SH3 domain containing A (UBASH3A) single nucleotide polymorphism (SNP) |
topic |
Autoimmune thyroid disease (AITD) Graves? disease (GD) Hashimoto?s thyroiditis (HT) ubiquitin associated and SH3 domain containing A (UBASH3A) single nucleotide polymorphism (SNP) |
description |
Objective: The aim of this study was to investigate UBASH3A gene variation association with autoimmune thyroid disease and clinical features in a Chinese Han population. Subjects and methods: A total of 667 AITD patients (417 GD and 250 HT) and 301 healthy controls were genotyped for two single nucleotide polymorphisms (SNPs) rs11203203, rs3788013 of UBASH3A gene, utilizing the Matrix Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometer (MALDI-TOF-MS) Platform. Results: Between the control group and AITD, GD and HT group, no statistically significant difference was observed in the genotypic and allelic frequencies of the two SNPs. There was no significant difference in allelic frequencies of the two SNPs between GD with and without ophthalmopathy. There was no significant difference in haplotype distributions between the control group and AITD, GD or HT group. Conclusion: Rs11203203 and rs3788013 in UBASH3A gene may not be associated with AITD patients in Chinese Han population. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000600640 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000600640 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-2730000003209 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.6 2014 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734812874145792 |