In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000200198 |
Resumo: | ABSTRACT Moussonia deppeana (Schltdl. & Cham.) Klotzsch ex Hanst., Gesneriaceae, known as tlachichinole, is a Mexican medicinal plant used for treatment of chronic inflammation-related diseases such as arthritis. In this paper, the main metabolite verbascoside was quantified in ethanolic extract; anti-arthritic and antioxidant activities were also evaluated in Complete Freund's Adjuvant induced arthritis in mice, with complete hematological evaluation, and oxidative stress measure in edema and ganglionic tissues on day 28. In popliteal ganglion, CD4+ lymphocytes and tumor necrosis factor alpha concentration were measured in addition to histological analysis. Ethanolic extract contained 79.2 mg of verbascoside/g extract, and this extract at 450 mg/kg generated an inhibition of 24% over paw edema development and increased body weight gain on final day. For hematological parameters, same dose decreased total leukocytes and lymphocytes, as well as decreased oxidation rate over biomolecules in edema and ganglionic tissues, and increased antioxidant enzyme activity. In ganglionic tissue, CD4+ lymphocytes and tumor necrosis factor alpha level showed no differences at any tested dose compared to complete Freund's adjuvant untreated group. Histological analysis of popliteal ganglion revealed moderate reduction of follicular hyperplasia, leukocyte infiltration and lipid inclusions at 450 mg/kg dose. Ethanolic extract of M. deppeana possesses anti-edematous activity associated to a moderate reduction in follicular hyperplasia, with immune-modulatory and antioxidant effects during experimental arthritis in mice. |
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In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeanaAnti-arthriticAntioxidantCFA-induced arthritisInterleukinsAnti-inflammatoryVerbascosideABSTRACT Moussonia deppeana (Schltdl. & Cham.) Klotzsch ex Hanst., Gesneriaceae, known as tlachichinole, is a Mexican medicinal plant used for treatment of chronic inflammation-related diseases such as arthritis. In this paper, the main metabolite verbascoside was quantified in ethanolic extract; anti-arthritic and antioxidant activities were also evaluated in Complete Freund's Adjuvant induced arthritis in mice, with complete hematological evaluation, and oxidative stress measure in edema and ganglionic tissues on day 28. In popliteal ganglion, CD4+ lymphocytes and tumor necrosis factor alpha concentration were measured in addition to histological analysis. Ethanolic extract contained 79.2 mg of verbascoside/g extract, and this extract at 450 mg/kg generated an inhibition of 24% over paw edema development and increased body weight gain on final day. For hematological parameters, same dose decreased total leukocytes and lymphocytes, as well as decreased oxidation rate over biomolecules in edema and ganglionic tissues, and increased antioxidant enzyme activity. In ganglionic tissue, CD4+ lymphocytes and tumor necrosis factor alpha level showed no differences at any tested dose compared to complete Freund's adjuvant untreated group. Histological analysis of popliteal ganglion revealed moderate reduction of follicular hyperplasia, leukocyte infiltration and lipid inclusions at 450 mg/kg dose. Ethanolic extract of M. deppeana possesses anti-edematous activity associated to a moderate reduction in follicular hyperplasia, with immune-modulatory and antioxidant effects during experimental arthritis in mice.Sociedade Brasileira de Farmacognosia2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000200198Revista Brasileira de Farmacognosia v.28 n.2 2018reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.02.004info:eu-repo/semantics/openAccessGutiérrez-Rebolledo,Gabriel A.Garduño-Siciliano,LeticiaChávez-Rueda,Adriana K.Siordia-Reyes,Alicia G.Zamilpa,AlejandroJiménez-Arellanes,María A.eng2018-06-06T00:00:00Zoai:scielo:S0102-695X2018000200198Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-06-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
title |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
spellingShingle |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana Gutiérrez-Rebolledo,Gabriel A. Anti-arthritic Antioxidant CFA-induced arthritis Interleukins Anti-inflammatory Verbascoside |
title_short |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
title_full |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
title_fullStr |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
title_full_unstemmed |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
title_sort |
In vivo anti-arthritic and antioxidant effects from the standardized ethanolic extract of Moussonia deppeana |
author |
Gutiérrez-Rebolledo,Gabriel A. |
author_facet |
Gutiérrez-Rebolledo,Gabriel A. Garduño-Siciliano,Leticia Chávez-Rueda,Adriana K. Siordia-Reyes,Alicia G. Zamilpa,Alejandro Jiménez-Arellanes,María A. |
author_role |
author |
author2 |
Garduño-Siciliano,Leticia Chávez-Rueda,Adriana K. Siordia-Reyes,Alicia G. Zamilpa,Alejandro Jiménez-Arellanes,María A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gutiérrez-Rebolledo,Gabriel A. Garduño-Siciliano,Leticia Chávez-Rueda,Adriana K. Siordia-Reyes,Alicia G. Zamilpa,Alejandro Jiménez-Arellanes,María A. |
dc.subject.por.fl_str_mv |
Anti-arthritic Antioxidant CFA-induced arthritis Interleukins Anti-inflammatory Verbascoside |
topic |
Anti-arthritic Antioxidant CFA-induced arthritis Interleukins Anti-inflammatory Verbascoside |
description |
ABSTRACT Moussonia deppeana (Schltdl. & Cham.) Klotzsch ex Hanst., Gesneriaceae, known as tlachichinole, is a Mexican medicinal plant used for treatment of chronic inflammation-related diseases such as arthritis. In this paper, the main metabolite verbascoside was quantified in ethanolic extract; anti-arthritic and antioxidant activities were also evaluated in Complete Freund's Adjuvant induced arthritis in mice, with complete hematological evaluation, and oxidative stress measure in edema and ganglionic tissues on day 28. In popliteal ganglion, CD4+ lymphocytes and tumor necrosis factor alpha concentration were measured in addition to histological analysis. Ethanolic extract contained 79.2 mg of verbascoside/g extract, and this extract at 450 mg/kg generated an inhibition of 24% over paw edema development and increased body weight gain on final day. For hematological parameters, same dose decreased total leukocytes and lymphocytes, as well as decreased oxidation rate over biomolecules in edema and ganglionic tissues, and increased antioxidant enzyme activity. In ganglionic tissue, CD4+ lymphocytes and tumor necrosis factor alpha level showed no differences at any tested dose compared to complete Freund's adjuvant untreated group. Histological analysis of popliteal ganglion revealed moderate reduction of follicular hyperplasia, leukocyte infiltration and lipid inclusions at 450 mg/kg dose. Ethanolic extract of M. deppeana possesses anti-edematous activity associated to a moderate reduction in follicular hyperplasia, with immune-modulatory and antioxidant effects during experimental arthritis in mice. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000200198 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000200198 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2018.02.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.28 n.2 2018 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122470654017536 |