Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)

Detalhes bibliográficos
Autor(a) principal: Rozas,Enrique E.
Data de Publicação: 2008
Outros Autores: Freitas,José C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200003
Resumo: Neurotoxic activity of polar substances extracted from the red seaweed Galaxaura marginata was investigated in pharmacological assays, using seaweed collected at São Sebastião channel (45º25' W; 26º49' S) in the northern coast of the State of São Paulo, Brazil. High concentration of the polar fraction (PF) and PF filtered through a membrane (1000 Da) intraperitoneally (IP) injected in mice were lethal, inducing ataxia, disorientation, and severe muscle atonia prior to death. The same symptoms preceding death were described in mice and rat tested with neuroexcitatory amino acids (NEA), suggesting that some PF components cross the blood-brain barrier, the same as NEA. However, the HPLC and mass spectrometric analysis did not show the presence of the known neuroexcitatory amino acids, kainic acid, domoic acid and NMDA. We conclude that G. marginata possess substances with neurotoxic and lethal activities.
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spelling Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)Galaxaura marginataneurotoxicneuroexcitatoryseaweedNeurotoxic activity of polar substances extracted from the red seaweed Galaxaura marginata was investigated in pharmacological assays, using seaweed collected at São Sebastião channel (45º25' W; 26º49' S) in the northern coast of the State of São Paulo, Brazil. High concentration of the polar fraction (PF) and PF filtered through a membrane (1000 Da) intraperitoneally (IP) injected in mice were lethal, inducing ataxia, disorientation, and severe muscle atonia prior to death. The same symptoms preceding death were described in mice and rat tested with neuroexcitatory amino acids (NEA), suggesting that some PF components cross the blood-brain barrier, the same as NEA. However, the HPLC and mass spectrometric analysis did not show the presence of the known neuroexcitatory amino acids, kainic acid, domoic acid and NMDA. We conclude that G. marginata possess substances with neurotoxic and lethal activities.Sociedade Brasileira de Farmacognosia2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200003Revista Brasileira de Farmacognosia v.18 n.2 2008reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2008000200003info:eu-repo/semantics/openAccessRozas,Enrique E.Freitas,José C.eng2008-08-01T00:00:00Zoai:scielo:S0102-695X2008000200003Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2008-08-01T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
title Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
spellingShingle Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
Rozas,Enrique E.
Galaxaura marginata
neurotoxic
neuroexcitatory
seaweed
title_short Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
title_full Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
title_fullStr Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
title_full_unstemmed Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
title_sort Neurotoxins in the polar fraction of the seaweed Galaxaura marginata (Rhodophyta, Nemaliales)
author Rozas,Enrique E.
author_facet Rozas,Enrique E.
Freitas,José C.
author_role author
author2 Freitas,José C.
author2_role author
dc.contributor.author.fl_str_mv Rozas,Enrique E.
Freitas,José C.
dc.subject.por.fl_str_mv Galaxaura marginata
neurotoxic
neuroexcitatory
seaweed
topic Galaxaura marginata
neurotoxic
neuroexcitatory
seaweed
description Neurotoxic activity of polar substances extracted from the red seaweed Galaxaura marginata was investigated in pharmacological assays, using seaweed collected at São Sebastião channel (45º25' W; 26º49' S) in the northern coast of the State of São Paulo, Brazil. High concentration of the polar fraction (PF) and PF filtered through a membrane (1000 Da) intraperitoneally (IP) injected in mice were lethal, inducing ataxia, disorientation, and severe muscle atonia prior to death. The same symptoms preceding death were described in mice and rat tested with neuroexcitatory amino acids (NEA), suggesting that some PF components cross the blood-brain barrier, the same as NEA. However, the HPLC and mass spectrometric analysis did not show the presence of the known neuroexcitatory amino acids, kainic acid, domoic acid and NMDA. We conclude that G. marginata possess substances with neurotoxic and lethal activities.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2008000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2008000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.18 n.2 2008
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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