Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae)
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100012 |
Resumo: | The purpose of the present work is to conduct an evaluation of the cytotoxicity of ethanol extracts and the total alkaloid fraction (TAF) from Crotalaria retusa for procyclic promastigotes cells of Leishmania chagasi. The kinetic study of extraction assisted by ultrasound of the total alkaloids present in Crotalaria retusa made it possible the optimization of the extraction parameters. It was evaluated the leishmanicide action of the TAF which did not show toxic activity for cells of the parasite in high concentrations. It was observed a powerful leishmanicide action of the ethanol extracts (10 and 30%) after the concentration of 5.6 mg/mL of Crotalaria retusa, and the ethanol present in the extractive solution (10 and 30%) in the concentration from 70 and 210 x 10-4 %, respectively. These results suggest that the cytotoxicity of the ethanol extract of Crotalaria retusa at 10 and 30% for cells of Leishmania chagasi, can be associated only to the concentration of the alcohol present in the extract. |
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Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae)Crotalaria retusaFabaceaeleishmanicide actionThe purpose of the present work is to conduct an evaluation of the cytotoxicity of ethanol extracts and the total alkaloid fraction (TAF) from Crotalaria retusa for procyclic promastigotes cells of Leishmania chagasi. The kinetic study of extraction assisted by ultrasound of the total alkaloids present in Crotalaria retusa made it possible the optimization of the extraction parameters. It was evaluated the leishmanicide action of the TAF which did not show toxic activity for cells of the parasite in high concentrations. It was observed a powerful leishmanicide action of the ethanol extracts (10 and 30%) after the concentration of 5.6 mg/mL of Crotalaria retusa, and the ethanol present in the extractive solution (10 and 30%) in the concentration from 70 and 210 x 10-4 %, respectively. These results suggest that the cytotoxicity of the ethanol extract of Crotalaria retusa at 10 and 30% for cells of Leishmania chagasi, can be associated only to the concentration of the alcohol present in the extract.Sociedade Brasileira de Farmacognosia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100012Revista Brasileira de Farmacognosia v.19 n.1a 2009reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2009000100012info:eu-repo/semantics/openAccessRocha,Louisianny Guerra daAragão,Cícero Flávio SoaresLoiola,Maria Iracema BezerraBezerril,Renata AracylPaiva,Nara Ruth FreitasHolanda,Cecília Maria Carvalho Xavier deBrito,Maria Edileuza Felinto deeng2009-08-11T00:00:00Zoai:scielo:S0102-695X2009000100012Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2009-08-11T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
title |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
spellingShingle |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) Rocha,Louisianny Guerra da Crotalaria retusa Fabaceae leishmanicide action |
title_short |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
title_full |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
title_fullStr |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
title_full_unstemmed |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
title_sort |
Evaluation of the leishmanicide action of ethanol extracts of Crotalaria retusa L. (Fabaceae) |
author |
Rocha,Louisianny Guerra da |
author_facet |
Rocha,Louisianny Guerra da Aragão,Cícero Flávio Soares Loiola,Maria Iracema Bezerra Bezerril,Renata Aracyl Paiva,Nara Ruth Freitas Holanda,Cecília Maria Carvalho Xavier de Brito,Maria Edileuza Felinto de |
author_role |
author |
author2 |
Aragão,Cícero Flávio Soares Loiola,Maria Iracema Bezerra Bezerril,Renata Aracyl Paiva,Nara Ruth Freitas Holanda,Cecília Maria Carvalho Xavier de Brito,Maria Edileuza Felinto de |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,Louisianny Guerra da Aragão,Cícero Flávio Soares Loiola,Maria Iracema Bezerra Bezerril,Renata Aracyl Paiva,Nara Ruth Freitas Holanda,Cecília Maria Carvalho Xavier de Brito,Maria Edileuza Felinto de |
dc.subject.por.fl_str_mv |
Crotalaria retusa Fabaceae leishmanicide action |
topic |
Crotalaria retusa Fabaceae leishmanicide action |
description |
The purpose of the present work is to conduct an evaluation of the cytotoxicity of ethanol extracts and the total alkaloid fraction (TAF) from Crotalaria retusa for procyclic promastigotes cells of Leishmania chagasi. The kinetic study of extraction assisted by ultrasound of the total alkaloids present in Crotalaria retusa made it possible the optimization of the extraction parameters. It was evaluated the leishmanicide action of the TAF which did not show toxic activity for cells of the parasite in high concentrations. It was observed a powerful leishmanicide action of the ethanol extracts (10 and 30%) after the concentration of 5.6 mg/mL of Crotalaria retusa, and the ethanol present in the extractive solution (10 and 30%) in the concentration from 70 and 210 x 10-4 %, respectively. These results suggest that the cytotoxicity of the ethanol extract of Crotalaria retusa at 10 and 30% for cells of Leishmania chagasi, can be associated only to the concentration of the alcohol present in the extract. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100012 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2009000100012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.19 n.1a 2009 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122463395774464 |