Biological activities of Juglans regia flowers

Detalhes bibliográficos
Autor(a) principal: Nabavi,Seyed Fazel
Data de Publicação: 2011
Outros Autores: Ebrahimzadeh,Mohammad Ali, Nabavi,Seyed Mohammad, Mahmoudi,Mitra, Rad,Shabnam Keyvani
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018
Resumo: Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract.
id SBFGNOSIA-1_cadd6cd509bee8c29aebb79d5d3edc6b
oai_identifier_str oai:scielo:S0102-695X2011000300018
network_acronym_str SBFGNOSIA-1
network_name_str Revista Brasileira de Farmacognosia (Online)
repository_id_str
spelling Biological activities of Juglans regia flowersantidepressant activityantioxidant activitywhenantihypoxic activityJuglans regiaAntidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract.Sociedade Brasileira de Farmacognosia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018Revista Brasileira de Farmacognosia v.21 n.3 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000092info:eu-repo/semantics/openAccessNabavi,Seyed FazelEbrahimzadeh,Mohammad AliNabavi,Seyed MohammadMahmoudi,MitraRad,Shabnam Keyvanieng2011-07-08T00:00:00Zoai:scielo:S0102-695X2011000300018Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-07-08T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Biological activities of Juglans regia flowers
title Biological activities of Juglans regia flowers
spellingShingle Biological activities of Juglans regia flowers
Nabavi,Seyed Fazel
antidepressant activity
antioxidant activitywhen
antihypoxic activity
Juglans regia
title_short Biological activities of Juglans regia flowers
title_full Biological activities of Juglans regia flowers
title_fullStr Biological activities of Juglans regia flowers
title_full_unstemmed Biological activities of Juglans regia flowers
title_sort Biological activities of Juglans regia flowers
author Nabavi,Seyed Fazel
author_facet Nabavi,Seyed Fazel
Ebrahimzadeh,Mohammad Ali
Nabavi,Seyed Mohammad
Mahmoudi,Mitra
Rad,Shabnam Keyvani
author_role author
author2 Ebrahimzadeh,Mohammad Ali
Nabavi,Seyed Mohammad
Mahmoudi,Mitra
Rad,Shabnam Keyvani
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nabavi,Seyed Fazel
Ebrahimzadeh,Mohammad Ali
Nabavi,Seyed Mohammad
Mahmoudi,Mitra
Rad,Shabnam Keyvani
dc.subject.por.fl_str_mv antidepressant activity
antioxidant activitywhen
antihypoxic activity
Juglans regia
topic antidepressant activity
antioxidant activitywhen
antihypoxic activity
Juglans regia
description Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000092
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.3 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
_version_ 1752122466050768896

Registros relacionados