Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system

Detalhes bibliográficos
Autor(a) principal: Khan,Mahmud T. H.
Data de Publicação: 2009
Outros Autores: Ather,Arjumand, Pinto,Angelo C., Maciel,Maria Aparecida M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100003
Resumo: This study examined the effect of trans-dehydrocrotonin (DCTN), a 19-nor-clerodane diterpene isolated from Croton cajucara Benth (Euphorbiaceae), as analgesic and its effect on the central nervous system (CNS) of rodents using different animal models. The DCTN intraperitoneally exhibited mild analgesic activity on hot-plate test, but exhibited strong antinociceptive activity against acetic acid-induced abdominal writhing and the ED50 was calculated to be 44.88 mg/kg. At higher doses (100 mg/kg) it exhibited mild CNS depressant activities in laboratory animals. Moreover, it has negligible antidepressant activity. After taking consideration of the drug interaction, the DCTN can be used as a potent analgesic agent in case of peripheral algesia, without affecting the CNS.
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spelling Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous systemCroton cajucaraEuphorbiaceaetrans-dehydrocrotonincentral nervous systemThis study examined the effect of trans-dehydrocrotonin (DCTN), a 19-nor-clerodane diterpene isolated from Croton cajucara Benth (Euphorbiaceae), as analgesic and its effect on the central nervous system (CNS) of rodents using different animal models. The DCTN intraperitoneally exhibited mild analgesic activity on hot-plate test, but exhibited strong antinociceptive activity against acetic acid-induced abdominal writhing and the ED50 was calculated to be 44.88 mg/kg. At higher doses (100 mg/kg) it exhibited mild CNS depressant activities in laboratory animals. Moreover, it has negligible antidepressant activity. After taking consideration of the drug interaction, the DCTN can be used as a potent analgesic agent in case of peripheral algesia, without affecting the CNS.Sociedade Brasileira de Farmacognosia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100003Revista Brasileira de Farmacognosia v.19 n.1a 2009reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2009000100003info:eu-repo/semantics/openAccessKhan,Mahmud T. H.Ather,ArjumandPinto,Angelo C.Maciel,Maria Aparecida M.eng2009-08-11T00:00:00Zoai:scielo:S0102-695X2009000100003Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2009-08-11T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
title Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
spellingShingle Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
Khan,Mahmud T. H.
Croton cajucara
Euphorbiaceae
trans-dehydrocrotonin
central nervous system
title_short Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
title_full Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
title_fullStr Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
title_full_unstemmed Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
title_sort Potential benefits of the 19-nor-clerodane trans-dehydrocrotonin on the central nervous system
author Khan,Mahmud T. H.
author_facet Khan,Mahmud T. H.
Ather,Arjumand
Pinto,Angelo C.
Maciel,Maria Aparecida M.
author_role author
author2 Ather,Arjumand
Pinto,Angelo C.
Maciel,Maria Aparecida M.
author2_role author
author
author
dc.contributor.author.fl_str_mv Khan,Mahmud T. H.
Ather,Arjumand
Pinto,Angelo C.
Maciel,Maria Aparecida M.
dc.subject.por.fl_str_mv Croton cajucara
Euphorbiaceae
trans-dehydrocrotonin
central nervous system
topic Croton cajucara
Euphorbiaceae
trans-dehydrocrotonin
central nervous system
description This study examined the effect of trans-dehydrocrotonin (DCTN), a 19-nor-clerodane diterpene isolated from Croton cajucara Benth (Euphorbiaceae), as analgesic and its effect on the central nervous system (CNS) of rodents using different animal models. The DCTN intraperitoneally exhibited mild analgesic activity on hot-plate test, but exhibited strong antinociceptive activity against acetic acid-induced abdominal writhing and the ED50 was calculated to be 44.88 mg/kg. At higher doses (100 mg/kg) it exhibited mild CNS depressant activities in laboratory animals. Moreover, it has negligible antidepressant activity. After taking consideration of the drug interaction, the DCTN can be used as a potent analgesic agent in case of peripheral algesia, without affecting the CNS.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2009000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.19 n.1a 2009
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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