Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population

Detalhes bibliográficos
Autor(a) principal: Fu,Xiaoyan
Data de Publicação: 2013
Outros Autores: Mei,Zhu, Sun,Lixin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400003
Resumo: Autism is a childhood neuro-developmental disorder, and Reelin (RELN) is an important candidate gene for influencing autism. This study aimed at investigating the influence of genetic variants of the RELN gene on autism susceptibility. In this study, 205 autism patients and 210 healthy controls were recruited and the genetic variants of the RELN gene were genotyped by the created restriction site-polymerase chain reaction (CRS-PCR) method. The influence of genetic variants on autism susceptibility was analyzed by association analysis, and the g.296596G > A genetic variant in exon10 of the RELN gene was detected. The frequencies of allele/genotype in autistic patients were significantly different from those in healthy controls, and a statistically significant association was detected between this genetic variant and autism susceptibility. Our data lead to the inference that the g.296596G > A genetic variant in the RELN gene has a potential influence on autism susceptibility in the Chinese Han population.
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spelling Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han populationautismsusceptibilityassociation analysisRELN genegenetic variantsAutism is a childhood neuro-developmental disorder, and Reelin (RELN) is an important candidate gene for influencing autism. This study aimed at investigating the influence of genetic variants of the RELN gene on autism susceptibility. In this study, 205 autism patients and 210 healthy controls were recruited and the genetic variants of the RELN gene were genotyped by the created restriction site-polymerase chain reaction (CRS-PCR) method. The influence of genetic variants on autism susceptibility was analyzed by association analysis, and the g.296596G > A genetic variant in exon10 of the RELN gene was detected. The frequencies of allele/genotype in autistic patients were significantly different from those in healthy controls, and a statistically significant association was detected between this genetic variant and autism susceptibility. Our data lead to the inference that the g.296596G > A genetic variant in the RELN gene has a potential influence on autism susceptibility in the Chinese Han population.Sociedade Brasileira de Genética2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400003Genetics and Molecular Biology v.36 n.4 2013reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572013005000037info:eu-repo/semantics/openAccessFu,XiaoyanMei,ZhuSun,Lixineng2015-07-28T00:00:00Zoai:scielo:S1415-47572013000400003Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2015-07-28T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
title Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
spellingShingle Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
Fu,Xiaoyan
autism
susceptibility
association analysis
RELN gene
genetic variants
title_short Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
title_full Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
title_fullStr Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
title_full_unstemmed Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
title_sort Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population
author Fu,Xiaoyan
author_facet Fu,Xiaoyan
Mei,Zhu
Sun,Lixin
author_role author
author2 Mei,Zhu
Sun,Lixin
author2_role author
author
dc.contributor.author.fl_str_mv Fu,Xiaoyan
Mei,Zhu
Sun,Lixin
dc.subject.por.fl_str_mv autism
susceptibility
association analysis
RELN gene
genetic variants
topic autism
susceptibility
association analysis
RELN gene
genetic variants
description Autism is a childhood neuro-developmental disorder, and Reelin (RELN) is an important candidate gene for influencing autism. This study aimed at investigating the influence of genetic variants of the RELN gene on autism susceptibility. In this study, 205 autism patients and 210 healthy controls were recruited and the genetic variants of the RELN gene were genotyped by the created restriction site-polymerase chain reaction (CRS-PCR) method. The influence of genetic variants on autism susceptibility was analyzed by association analysis, and the g.296596G > A genetic variant in exon10 of the RELN gene was detected. The frequencies of allele/genotype in autistic patients were significantly different from those in healthy controls, and a statistically significant association was detected between this genetic variant and autism susceptibility. Our data lead to the inference that the g.296596G > A genetic variant in the RELN gene has a potential influence on autism susceptibility in the Chinese Han population.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000400003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572013005000037
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.36 n.4 2013
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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