Expression of D-type cyclins in differentiating cells of the mouse spinal cord
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032 |
Resumo: | The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing midbrain-hindbrain region the D-type cyclins were expressed in different subsets of cells. Our results argue in favor of different functions for D-type cyclins during proliferation and differentiation of neural progenitors. |
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Genetics and Molecular Biology |
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Expression of D-type cyclins in differentiating cells of the mouse spinal cordcell cycleD-type cyclinsmidbrain-hindbrain regionneurogenesisspinal cordThe D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing midbrain-hindbrain region the D-type cyclins were expressed in different subsets of cells. Our results argue in favor of different functions for D-type cyclins during proliferation and differentiation of neural progenitors.Sociedade Brasileira de Genética2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032Genetics and Molecular Biology v.30 n.3 2007reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572007000400032info:eu-repo/semantics/openAccessSalles,Patricy de AndradeFortes,Juliana ChagasGuedes,Maria Izabel FlorindoWeller,Mathiaseng2007-08-30T00:00:00Zoai:scielo:S1415-47572007000400032Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2007-08-30T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
title |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
spellingShingle |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord Salles,Patricy de Andrade cell cycle D-type cyclins midbrain-hindbrain region neurogenesis spinal cord |
title_short |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
title_full |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
title_fullStr |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
title_full_unstemmed |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
title_sort |
Expression of D-type cyclins in differentiating cells of the mouse spinal cord |
author |
Salles,Patricy de Andrade |
author_facet |
Salles,Patricy de Andrade Fortes,Juliana Chagas Guedes,Maria Izabel Florindo Weller,Mathias |
author_role |
author |
author2 |
Fortes,Juliana Chagas Guedes,Maria Izabel Florindo Weller,Mathias |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Salles,Patricy de Andrade Fortes,Juliana Chagas Guedes,Maria Izabel Florindo Weller,Mathias |
dc.subject.por.fl_str_mv |
cell cycle D-type cyclins midbrain-hindbrain region neurogenesis spinal cord |
topic |
cell cycle D-type cyclins midbrain-hindbrain region neurogenesis spinal cord |
description |
The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing midbrain-hindbrain region the D-type cyclins were expressed in different subsets of cells. Our results argue in favor of different functions for D-type cyclins during proliferation and differentiation of neural progenitors. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-47572007000400032 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.30 n.3 2007 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
_version_ |
1752122380709265408 |