[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Genetics and Molecular Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300525 |
Resumo: | Abstract Studies have demonstrated that miRNA-378 is expressed in various malignant tumors. In the present study, we aimed to explore the expression of serum miRNA-378 and its clinical significance in renal cell carcinoma (RCC) patients. A total of 75 RCC patients, 63 renal cysts (RC) patients and 75 healthy controls were selected. The miRNA-378 level in RCC and RC groups was significantly higher than in healthy control group, with RCC group having the highest level. The miRNA-378 levels were significantly decreased within the same group after surgery. When compared with healthy controls, RC group had higher levels but not significantly (p > 0.05) while levels in RCC group were significantly higher (p < 0.05). miRNA-378 expression was correlated with clinical stage and differentiation degree, but not correlated with patient's age, gender, surgical strategy and tumor diameter. The AUC of miRNA-378 was 0.896, 95% confidence interval was 0.847 to 0.945, and AUC hypothesis testing was statistically significant (p < 0.001, RCC vs healthy control). miRNA-378 shows potential in the diagnosis and prediction of postoperative curative effect of renal cell carcinoma, but further studies with lager samples are needed. |
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[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinomaRenal cell carcinomamicroRNA 378diagnosispatientsAUCAbstract Studies have demonstrated that miRNA-378 is expressed in various malignant tumors. In the present study, we aimed to explore the expression of serum miRNA-378 and its clinical significance in renal cell carcinoma (RCC) patients. A total of 75 RCC patients, 63 renal cysts (RC) patients and 75 healthy controls were selected. The miRNA-378 level in RCC and RC groups was significantly higher than in healthy control group, with RCC group having the highest level. The miRNA-378 levels were significantly decreased within the same group after surgery. When compared with healthy controls, RC group had higher levels but not significantly (p > 0.05) while levels in RCC group were significantly higher (p < 0.05). miRNA-378 expression was correlated with clinical stage and differentiation degree, but not correlated with patient's age, gender, surgical strategy and tumor diameter. The AUC of miRNA-378 was 0.896, 95% confidence interval was 0.847 to 0.945, and AUC hypothesis testing was statistically significant (p < 0.001, RCC vs healthy control). miRNA-378 shows potential in the diagnosis and prediction of postoperative curative effect of renal cell carcinoma, but further studies with lager samples are needed.Sociedade Brasileira de Genética2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300525Genetics and Molecular Biology v.40 n.2 2017reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/1678-4685-gmb-2016-0121info:eu-repo/semantics/openAccessShi,LixinZhang,LeiWang,ChunyangSun,ShengkunCao,XiyuanZhang,Xueng2020-04-01T00:00:00Zoai:scielo:S1415-47572017000300525Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2020-04-01T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false |
dc.title.none.fl_str_mv |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
title |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
spellingShingle |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma Shi,Lixin Renal cell carcinoma microRNA 378 diagnosis patients AUC |
title_short |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
title_full |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
title_fullStr |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
title_full_unstemmed |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
title_sort |
[RETRACTED ARTICLE]: Expression of serum microRNA-378 and its clinical significance in renal cell carcinoma |
author |
Shi,Lixin |
author_facet |
Shi,Lixin Zhang,Lei Wang,Chunyang Sun,Shengkun Cao,Xiyuan Zhang,Xu |
author_role |
author |
author2 |
Zhang,Lei Wang,Chunyang Sun,Shengkun Cao,Xiyuan Zhang,Xu |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Shi,Lixin Zhang,Lei Wang,Chunyang Sun,Shengkun Cao,Xiyuan Zhang,Xu |
dc.subject.por.fl_str_mv |
Renal cell carcinoma microRNA 378 diagnosis patients AUC |
topic |
Renal cell carcinoma microRNA 378 diagnosis patients AUC |
description |
Abstract Studies have demonstrated that miRNA-378 is expressed in various malignant tumors. In the present study, we aimed to explore the expression of serum miRNA-378 and its clinical significance in renal cell carcinoma (RCC) patients. A total of 75 RCC patients, 63 renal cysts (RC) patients and 75 healthy controls were selected. The miRNA-378 level in RCC and RC groups was significantly higher than in healthy control group, with RCC group having the highest level. The miRNA-378 levels were significantly decreased within the same group after surgery. When compared with healthy controls, RC group had higher levels but not significantly (p > 0.05) while levels in RCC group were significantly higher (p < 0.05). miRNA-378 expression was correlated with clinical stage and differentiation degree, but not correlated with patient's age, gender, surgical strategy and tumor diameter. The AUC of miRNA-378 was 0.896, 95% confidence interval was 0.847 to 0.945, and AUC hypothesis testing was statistically significant (p < 0.001, RCC vs healthy control). miRNA-378 shows potential in the diagnosis and prediction of postoperative curative effect of renal cell carcinoma, but further studies with lager samples are needed. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300525 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300525 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1678-4685-gmb-2016-0121 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
publisher.none.fl_str_mv |
Sociedade Brasileira de Genética |
dc.source.none.fl_str_mv |
Genetics and Molecular Biology v.40 n.2 2017 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
instname_str |
Sociedade Brasileira de Genética (SBG) |
instacron_str |
SBG |
institution |
SBG |
reponame_str |
Genetics and Molecular Biology |
collection |
Genetics and Molecular Biology |
repository.name.fl_str_mv |
Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG) |
repository.mail.fl_str_mv |
||editor@gmb.org.br |
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1752122387202048000 |