Arterial hypertension impact on cerebral blood flow in patients with Alzheimer’s disease

• Autor(a) principal: Attier-Zmudka,Jadwiga
• Data de Publicação: 2017
• Outros Autores: Bouzerar,Roger, Gondry,Catherine, Couvillers,Frederique, Chaarani,Bader, Balédent,Olivier
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Geriatrics, Gerontology and Aging (Online)
• Texto Completo: https://ggaging.com/details/432
• topic: aging; Alzheimer disease; hypertension; blood flow velocity; contrast media; magnetic resonance imaging.

<p><b>BACKGROUND:</b> Studies show the potential deterioration of brain vascularization and probable involvement of hypertension in Alzheimer disease (AD).<br> <b>OBJECTIVE:</b> The objective was to evaluate the potential impact of hypertension on cerebral vascular flows in a sample of Alzheimer's patients.<br> <b>METHODS:</b> 19 patients with AD, including 10 with hypertension (aHT+) and 9 without hypertension (aHT-) were recruited. They underwent clinical evaluation and phase-contrast MRI protocol for flow assessment. Cerebral arterial flow distributions were evaluated using kurtosis and skewness indices at the intracranial and extracranial levels.<br> <b>RESULTS:</b> No significant differences were found in the mean arterial flow, pulse flow and kurtosis between the levels in the AD aHT+ population. There was a significant difference in skewness between extra- and intracranial levels (p = 0.01). No significant differences were found in the mean arterial flow between the levels in the AD aHT- population. A significant difference was observed in the pulse flow (p = 0.03), kurtosis (p = 0.02) and skewness (p = 0.008) between the levels. At the extracranial level we did not find any significant differences in the mean arterial flow, pulse flow or skewness between aHT+ and aHT-. There was a significant difference in kurtosis at the extracranial level between the aHT+ and aHT- (p = 0.03). At the intracranial level, there were no significant differences in all parameters.<br> <b>CONCLUSION:</b> Results showed a difference between cerebral vasculature in AD for aHT+ and aHT- groups. This is probably related to the loss of arterial compliance induced by the degradation of the vascular system.</p>