Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000300305 |
Resumo: | Abstract: INTRODUCTION: The spread of multidrug-resistant Pseudomonas aeruginosa in Brazilian hospitals has greatly impacted upon the morbidity and mortality of individuals in intensive care units. Given the lack of information regarding the dynamics of multidrug resistance in northern Brazil, we analyzed the clinical and microbiological features of nosocomial infections caused by P. aeruginosa. METHODS Between January 2010 and March 2012, we conducted a retrospective cohort study of P. aeruginosa isolates from 54 patients who were hospitalized in intensive care units. The clinical and epidemiologic variables were analyzed, including the patients' demographic data and comorbidities, and the lengths of the intensive care unit stays, the classification of the infections as nosocomial, the use of invasive procedures, antimicrobial therapy, and the patients' outcomes. We undertook susceptibility tests, molecular detection of the metallo-β-lactamase genes, and genotypic analyses of the isolates using the repetitive element-polymerase chain reaction. RESULTS: Multidrug resistance occurred most frequently among isolates from adults who had been hospitalized for an average of 87.1 days. The use of mechanical ventilation and urinary catheters were risk factors for infection. The four isolates that harbored the blaSPM-1-like gene showed >95% genetic similarity. CONCLUSIONS This study's findings show that P. aeruginosa has a high death rate, and that inadequate treatment and invasive procedures are risk factors for infection. This is the first report describing the detection of the blaSPM-1-like gene in northern Brazil. These results highlight the need for better monitoring and a greater understanding of nosocomial infections and their public health impacts. |
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Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care unitsPseudomonas aeruginosaNosocomial infectionAntimicrobial resistanceClinical featuresIntensive care unitAbstract: INTRODUCTION: The spread of multidrug-resistant Pseudomonas aeruginosa in Brazilian hospitals has greatly impacted upon the morbidity and mortality of individuals in intensive care units. Given the lack of information regarding the dynamics of multidrug resistance in northern Brazil, we analyzed the clinical and microbiological features of nosocomial infections caused by P. aeruginosa. METHODS Between January 2010 and March 2012, we conducted a retrospective cohort study of P. aeruginosa isolates from 54 patients who were hospitalized in intensive care units. The clinical and epidemiologic variables were analyzed, including the patients' demographic data and comorbidities, and the lengths of the intensive care unit stays, the classification of the infections as nosocomial, the use of invasive procedures, antimicrobial therapy, and the patients' outcomes. We undertook susceptibility tests, molecular detection of the metallo-β-lactamase genes, and genotypic analyses of the isolates using the repetitive element-polymerase chain reaction. RESULTS: Multidrug resistance occurred most frequently among isolates from adults who had been hospitalized for an average of 87.1 days. The use of mechanical ventilation and urinary catheters were risk factors for infection. The four isolates that harbored the blaSPM-1-like gene showed >95% genetic similarity. CONCLUSIONS This study's findings show that P. aeruginosa has a high death rate, and that inadequate treatment and invasive procedures are risk factors for infection. This is the first report describing the detection of the blaSPM-1-like gene in northern Brazil. These results highlight the need for better monitoring and a greater understanding of nosocomial infections and their public health impacts.Sociedade Brasileira de Medicina Tropical - SBMT2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000300305Revista da Sociedade Brasileira de Medicina Tropical v.49 n.3 2016reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/0037-8682-0446-2015info:eu-repo/semantics/openAccessMatos,Eliseth Costa Oliveira deMatos,Haroldo José deConceição,Marília LimaRodrigues,Yan CorrêaCarneiro,Irna Carla do Rosário SouzaLima,Karla Valéria Batistaeng2016-09-19T00:00:00Zoai:scielo:S0037-86822016000300305Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2016-09-19T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
title |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
spellingShingle |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units Matos,Eliseth Costa Oliveira de Pseudomonas aeruginosa Nosocomial infection Antimicrobial resistance Clinical features Intensive care unit |
title_short |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
title_full |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
title_fullStr |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
title_full_unstemmed |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
title_sort |
Clinical and microbiological features of infections caused by Pseudomonas aeruginosa in patients hospitalized in intensive care units |
author |
Matos,Eliseth Costa Oliveira de |
author_facet |
Matos,Eliseth Costa Oliveira de Matos,Haroldo José de Conceição,Marília Lima Rodrigues,Yan Corrêa Carneiro,Irna Carla do Rosário Souza Lima,Karla Valéria Batista |
author_role |
author |
author2 |
Matos,Haroldo José de Conceição,Marília Lima Rodrigues,Yan Corrêa Carneiro,Irna Carla do Rosário Souza Lima,Karla Valéria Batista |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Matos,Eliseth Costa Oliveira de Matos,Haroldo José de Conceição,Marília Lima Rodrigues,Yan Corrêa Carneiro,Irna Carla do Rosário Souza Lima,Karla Valéria Batista |
dc.subject.por.fl_str_mv |
Pseudomonas aeruginosa Nosocomial infection Antimicrobial resistance Clinical features Intensive care unit |
topic |
Pseudomonas aeruginosa Nosocomial infection Antimicrobial resistance Clinical features Intensive care unit |
description |
Abstract: INTRODUCTION: The spread of multidrug-resistant Pseudomonas aeruginosa in Brazilian hospitals has greatly impacted upon the morbidity and mortality of individuals in intensive care units. Given the lack of information regarding the dynamics of multidrug resistance in northern Brazil, we analyzed the clinical and microbiological features of nosocomial infections caused by P. aeruginosa. METHODS Between January 2010 and March 2012, we conducted a retrospective cohort study of P. aeruginosa isolates from 54 patients who were hospitalized in intensive care units. The clinical and epidemiologic variables were analyzed, including the patients' demographic data and comorbidities, and the lengths of the intensive care unit stays, the classification of the infections as nosocomial, the use of invasive procedures, antimicrobial therapy, and the patients' outcomes. We undertook susceptibility tests, molecular detection of the metallo-β-lactamase genes, and genotypic analyses of the isolates using the repetitive element-polymerase chain reaction. RESULTS: Multidrug resistance occurred most frequently among isolates from adults who had been hospitalized for an average of 87.1 days. The use of mechanical ventilation and urinary catheters were risk factors for infection. The four isolates that harbored the blaSPM-1-like gene showed >95% genetic similarity. CONCLUSIONS This study's findings show that P. aeruginosa has a high death rate, and that inadequate treatment and invasive procedures are risk factors for infection. This is the first report describing the detection of the blaSPM-1-like gene in northern Brazil. These results highlight the need for better monitoring and a greater understanding of nosocomial infections and their public health impacts. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000300305 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000300305 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0037-8682-0446-2015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.49 n.3 2016 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
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