Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi
Autor(a) principal: | |
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Data de Publicação: | 1986 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Sociedade Brasileira de Medicina Tropical |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000300006 |
Resumo: | In this experiment, the effect of betamethasone administered in the early post- acute infection of mice by Trypanosoma cruzi was studied. This drug was administered during 30 days after the 42nd day of infection in a dose of 0.15 mg/day. The betamethasone treatment did not cause fresh outbreaks of parasitemia and the histopathological findings in the chronic phase were not different from those in the control group. The higher cumulative mortality after treatment in the experimental group was due to superimposed bacterial infections. Outbred albino mice infected with low numbers ofY strain Trypanosoma cruzi trypomastigotes were not suitable models for Chagas' disease, since after 7 months of observation only mild histological lesions developed in all the animais. Prolonged betamethasone treatment of mice infected with low numbers o/Trypanosoma cruzi of the Y strain, during the post-acute phase did not aggravate the course of infection. |
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Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruziChagas' diseaseTrypanosomiasisImmunosuppressionBetamethasoneLight Trypanosoma cruzi infectionIn this experiment, the effect of betamethasone administered in the early post- acute infection of mice by Trypanosoma cruzi was studied. This drug was administered during 30 days after the 42nd day of infection in a dose of 0.15 mg/day. The betamethasone treatment did not cause fresh outbreaks of parasitemia and the histopathological findings in the chronic phase were not different from those in the control group. The higher cumulative mortality after treatment in the experimental group was due to superimposed bacterial infections. Outbred albino mice infected with low numbers ofY strain Trypanosoma cruzi trypomastigotes were not suitable models for Chagas' disease, since after 7 months of observation only mild histological lesions developed in all the animais. Prolonged betamethasone treatment of mice infected with low numbers o/Trypanosoma cruzi of the Y strain, during the post-acute phase did not aggravate the course of infection.Sociedade Brasileira de Medicina Tropical - SBMT1986-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000300006Revista da Sociedade Brasileira de Medicina Tropical v.19 n.3 1986reponame:Revista da Sociedade Brasileira de Medicina Tropicalinstname:Sociedade Brasileira de Medicina Tropical (SBMT)instacron:SBMT10.1590/S0037-86821986000300006info:eu-repo/semantics/openAccessAbath,Frederico G.C.Gomes,Yara M.Coutinho,Eridan M.Montenegro,Silvia M.L.Melo,Maria E.B.Carvalho,Alexandre B.eng2013-06-06T00:00:00Zoai:scielo:S0037-86821986000300006Revistahttps://www.sbmt.org.br/portal/revista/ONGhttps://old.scielo.br/oai/scielo-oai.php||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br1678-98490037-8682opendoar:2013-06-06T00:00Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT)false |
dc.title.none.fl_str_mv |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
title |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
spellingShingle |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi Abath,Frederico G.C. Chagas' disease Trypanosomiasis Immunosuppression Betamethasone Light Trypanosoma cruzi infection |
title_short |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
title_full |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
title_fullStr |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
title_full_unstemmed |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
title_sort |
Effects of betamethasone on the course of experimentai. Infection with Trypanosoma cruzi |
author |
Abath,Frederico G.C. |
author_facet |
Abath,Frederico G.C. Gomes,Yara M. Coutinho,Eridan M. Montenegro,Silvia M.L. Melo,Maria E.B. Carvalho,Alexandre B. |
author_role |
author |
author2 |
Gomes,Yara M. Coutinho,Eridan M. Montenegro,Silvia M.L. Melo,Maria E.B. Carvalho,Alexandre B. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Abath,Frederico G.C. Gomes,Yara M. Coutinho,Eridan M. Montenegro,Silvia M.L. Melo,Maria E.B. Carvalho,Alexandre B. |
dc.subject.por.fl_str_mv |
Chagas' disease Trypanosomiasis Immunosuppression Betamethasone Light Trypanosoma cruzi infection |
topic |
Chagas' disease Trypanosomiasis Immunosuppression Betamethasone Light Trypanosoma cruzi infection |
description |
In this experiment, the effect of betamethasone administered in the early post- acute infection of mice by Trypanosoma cruzi was studied. This drug was administered during 30 days after the 42nd day of infection in a dose of 0.15 mg/day. The betamethasone treatment did not cause fresh outbreaks of parasitemia and the histopathological findings in the chronic phase were not different from those in the control group. The higher cumulative mortality after treatment in the experimental group was due to superimposed bacterial infections. Outbred albino mice infected with low numbers ofY strain Trypanosoma cruzi trypomastigotes were not suitable models for Chagas' disease, since after 7 months of observation only mild histological lesions developed in all the animais. Prolonged betamethasone treatment of mice infected with low numbers o/Trypanosoma cruzi of the Y strain, during the post-acute phase did not aggravate the course of infection. |
publishDate |
1986 |
dc.date.none.fl_str_mv |
1986-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821986000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0037-86821986000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
publisher.none.fl_str_mv |
Sociedade Brasileira de Medicina Tropical - SBMT |
dc.source.none.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical v.19 n.3 1986 reponame:Revista da Sociedade Brasileira de Medicina Tropical instname:Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT |
instname_str |
Sociedade Brasileira de Medicina Tropical (SBMT) |
instacron_str |
SBMT |
institution |
SBMT |
reponame_str |
Revista da Sociedade Brasileira de Medicina Tropical |
collection |
Revista da Sociedade Brasileira de Medicina Tropical |
repository.name.fl_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT) |
repository.mail.fl_str_mv |
||dalmo@rsbmt.uftm.edu.br|| rsbmt@rsbmt.uftm.edu.br |
_version_ |
1752122148339580928 |