Induction and nosocomial dissemination of carbapenem and polymyxin-resistant Klebsiella pneumoniae

• Autor(a) principal: Gaspar,Gilberto Gambero
• Data de Publicação: 2015
• Outros Autores: Bellissimo-Rodrigues,Fernando, Andrade,Leonardo Neves de, Darini,Ana Lúcia, Martinez,Roberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista da Sociedade Brasileira de Medicina Tropical
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000400483
• topic: Klebsiella pneumonia; KPC; Polymyxin B; Colistin

INTRODUCTION:Polymyxins are antimicrobial agents capable of controlling carbapenemase-producing Klebsiella pneumoniae infection.METHODS: We report a cluster of four patients colonized or infected by polymyxin-resistant and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae.RESULTS: Three patients were hospitalized in adjacent wards, and two were admitted to the intensive care unit. The index case maintained prolonged intestinal colonization by KPC-producing K. pneumoniae. Three patients received polymyxin B before the isolation of polymyxin-resistant K. pneumoniae.CONCLUSIONS: Colonization by KPC-producing K. pneumoniae and previous use of polymyxin B may be causally related to the development of polymyxin-resistant microorganisms.