Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Jornal Brasileiro de Nefrologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481 |
Resumo: | ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited. |
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Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature reviewacidosisacidosis, renal tubulardiabetes mellitushyperkalemiahypoaldosteronismABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited.Sociedade Brasileira de Nefrologia2017-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481Brazilian Journal of Nephrology v.39 n.4 2017reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.5935/0101-2800.20170086info:eu-repo/semantics/openAccessBello,Carlos Henrique Pires Ratto TavaresDuarte,João SequeiraVasconcelos,Carloseng2018-01-04T00:00:00Zoai:scielo:S0101-28002017000400481Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2018-01-04T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false |
dc.title.none.fl_str_mv |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
title |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
spellingShingle |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review Bello,Carlos Henrique Pires Ratto Tavares acidosis acidosis, renal tubular diabetes mellitus hyperkalemia hypoaldosteronism |
title_short |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
title_full |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
title_fullStr |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
title_full_unstemmed |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
title_sort |
Diabetes mellitus and hyperkalemic renal tubular acidosis: case reports and literature review |
author |
Bello,Carlos Henrique Pires Ratto Tavares |
author_facet |
Bello,Carlos Henrique Pires Ratto Tavares Duarte,João Sequeira Vasconcelos,Carlos |
author_role |
author |
author2 |
Duarte,João Sequeira Vasconcelos,Carlos |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Bello,Carlos Henrique Pires Ratto Tavares Duarte,João Sequeira Vasconcelos,Carlos |
dc.subject.por.fl_str_mv |
acidosis acidosis, renal tubular diabetes mellitus hyperkalemia hypoaldosteronism |
topic |
acidosis acidosis, renal tubular diabetes mellitus hyperkalemia hypoaldosteronism |
description |
ABSTRACT Hyporeninemic hypoaldosteronism, despite being common, remains an underdiagnosed entity that is more prevalent in patients with diabetes mellitus. It presents with asymptomatic hyperkalemia along with hyperchloraemic metabolic acidosis without significant renal function impairment. The underlying pathophysiological mechanism is not fully understood, but it is postulated that either aldosterone deficiency (hyporeninemic hypoaldosteronism) and/or target organ aldosterone resistance (pseudohypoaldosteronism) may be responsible. Diagnosis is based on laboratory parameters. Treatment strategy varies according to the underlying pathophysiological mechanism and etiology and aims to normalize serum potassium. Two clínical cases are reported and the relevant literature is revisited. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002017000400481 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0101-2800.20170086 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Nefrologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Nephrology v.39 n.4 2017 reponame:Jornal Brasileiro de Nefrologia instname:Sociedade Brasileira de Nefrologia (SBN) instacron:SBN |
instname_str |
Sociedade Brasileira de Nefrologia (SBN) |
instacron_str |
SBN |
institution |
SBN |
reponame_str |
Jornal Brasileiro de Nefrologia |
collection |
Jornal Brasileiro de Nefrologia |
repository.name.fl_str_mv |
Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN) |
repository.mail.fl_str_mv |
||jbn@sbn.org.br |
_version_ |
1752122064603447296 |