Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review

Detalhes bibliográficos
Autor(a) principal: Cambruzzi,Eduardo
Data de Publicação: 2019
Outros Autores: Pêgas,Karla Lais
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Jornal Brasileiro de Nefrologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000300393
Resumo: Abstract Lipoprotein glomerulopathy (LPG) is an uncommon cause of nephrotic syndrome and/or kidney failure. At microscopy, LPG is characterized by the presence of lipoprotein thrombi in dilated glomerular capillaries due to different ApoE mutations. ApoE gene is located on chromosome 19q13.2, and can be identified in almost all serum lipoproteins. ApoE works as a protective factor in atherosclerosis due its interaction with receptor-mediated lipoprotein clearance and cholesterol receptor. Most common polymorphisms include ApoE2/2, ApoE3/2, ApoE3/3, ApoE4/2, ApoE4/3, and ApoE4/4. All age-groups can be affected by LPG, with a discrete male predominance. Compromised patients typically reveal dyslipidemia, type III hyperlipoproteinemia, and proteinuria. LPG treatment includes fenofibrate, antilipidemic drugs, steroids, LDL aphaeresis, plasma exchange, antiplatelet drugs, anticoagulants, urokinase, and renal transplantation. Recurrence in kidney graft suggests a pathogenic component(s) of extraglomerular humoral complex resulting from abnormal lipoprotein metabolism and presumably associated to ApoE.
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spelling Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A reviewRenal Insufficiency, ChronicLipoproteinKidney DiseasesApolipoproteinNephrotic SyndromeFenofibrateAbstract Lipoprotein glomerulopathy (LPG) is an uncommon cause of nephrotic syndrome and/or kidney failure. At microscopy, LPG is characterized by the presence of lipoprotein thrombi in dilated glomerular capillaries due to different ApoE mutations. ApoE gene is located on chromosome 19q13.2, and can be identified in almost all serum lipoproteins. ApoE works as a protective factor in atherosclerosis due its interaction with receptor-mediated lipoprotein clearance and cholesterol receptor. Most common polymorphisms include ApoE2/2, ApoE3/2, ApoE3/3, ApoE4/2, ApoE4/3, and ApoE4/4. All age-groups can be affected by LPG, with a discrete male predominance. Compromised patients typically reveal dyslipidemia, type III hyperlipoproteinemia, and proteinuria. LPG treatment includes fenofibrate, antilipidemic drugs, steroids, LDL aphaeresis, plasma exchange, antiplatelet drugs, anticoagulants, urokinase, and renal transplantation. Recurrence in kidney graft suggests a pathogenic component(s) of extraglomerular humoral complex resulting from abnormal lipoprotein metabolism and presumably associated to ApoE.Sociedade Brasileira de Nefrologia2019-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000300393Brazilian Journal of Nephrology v.41 n.3 2019reponame:Jornal Brasileiro de Nefrologiainstname:Sociedade Brasileira de Nefrologia (SBN)instacron:SBN10.1590/2175-8239-jbn-2018-0148info:eu-repo/semantics/openAccessCambruzzi,EduardoPêgas,Karla Laiseng2019-09-24T00:00:00Zoai:scielo:S0101-28002019000300393Revistahttp://www.bjn.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||jbn@sbn.org.br2175-82390101-2800opendoar:2019-09-24T00:00Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)false
dc.title.none.fl_str_mv Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
title Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
spellingShingle Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
Cambruzzi,Eduardo
Renal Insufficiency, Chronic
Lipoprotein
Kidney Diseases
Apolipoprotein
Nephrotic Syndrome
Fenofibrate
title_short Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
title_full Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
title_fullStr Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
title_full_unstemmed Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
title_sort Pathogenesis, histopathologic findings and treatment modalities of lipoprotein glomerulopathy: A review
author Cambruzzi,Eduardo
author_facet Cambruzzi,Eduardo
Pêgas,Karla Lais
author_role author
author2 Pêgas,Karla Lais
author2_role author
dc.contributor.author.fl_str_mv Cambruzzi,Eduardo
Pêgas,Karla Lais
dc.subject.por.fl_str_mv Renal Insufficiency, Chronic
Lipoprotein
Kidney Diseases
Apolipoprotein
Nephrotic Syndrome
Fenofibrate
topic Renal Insufficiency, Chronic
Lipoprotein
Kidney Diseases
Apolipoprotein
Nephrotic Syndrome
Fenofibrate
description Abstract Lipoprotein glomerulopathy (LPG) is an uncommon cause of nephrotic syndrome and/or kidney failure. At microscopy, LPG is characterized by the presence of lipoprotein thrombi in dilated glomerular capillaries due to different ApoE mutations. ApoE gene is located on chromosome 19q13.2, and can be identified in almost all serum lipoproteins. ApoE works as a protective factor in atherosclerosis due its interaction with receptor-mediated lipoprotein clearance and cholesterol receptor. Most common polymorphisms include ApoE2/2, ApoE3/2, ApoE3/3, ApoE4/2, ApoE4/3, and ApoE4/4. All age-groups can be affected by LPG, with a discrete male predominance. Compromised patients typically reveal dyslipidemia, type III hyperlipoproteinemia, and proteinuria. LPG treatment includes fenofibrate, antilipidemic drugs, steroids, LDL aphaeresis, plasma exchange, antiplatelet drugs, anticoagulants, urokinase, and renal transplantation. Recurrence in kidney graft suggests a pathogenic component(s) of extraglomerular humoral complex resulting from abnormal lipoprotein metabolism and presumably associated to ApoE.
publishDate 2019
dc.date.none.fl_str_mv 2019-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000300393
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002019000300393
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2175-8239-jbn-2018-0148
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv Brazilian Journal of Nephrology v.41 n.3 2019
reponame:Jornal Brasileiro de Nefrologia
instname:Sociedade Brasileira de Nefrologia (SBN)
instacron:SBN
instname_str Sociedade Brasileira de Nefrologia (SBN)
instacron_str SBN
institution SBN
reponame_str Jornal Brasileiro de Nefrologia
collection Jornal Brasileiro de Nefrologia
repository.name.fl_str_mv Jornal Brasileiro de Nefrologia - Sociedade Brasileira de Nefrologia (SBN)
repository.mail.fl_str_mv ||jbn@sbn.org.br
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