Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Ortopedia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000300366 |
Resumo: | ABSTRACT Hemosiderotic fibrohistiocytic lipomatous tumors are rare neoplasms that were first described in 2000. Initially considered a benign lipotamous lesion of the soft tissues, nowadays they are considered to be a locally aggressive tumor. They occur mainly in the foot and ankle of women in their fifth and sixth decades, although they may be found in any place in the lower limbs and, more rarely, in other parts of the body. Histologically, hemosiderotic fibrohistiocytic lipomatous tumors consist of a mixture of mature adipose tissue, fusiform cell fascicles, macrophages that often contain cytoplasmic hemosiderin, mononuclear inflammatory infiltrate, and stroma that may be focally myxoid. Local recurrence is observed in nearly one-third of all cases. There is no consensus in the literature whether this tumor is a part of a spectrum that comprises pleomorphic hyalinizing angiectatic tumors and myxoinflammatory fibroblastic malignant tumors, or if it is an independent entity. The authors report a case of a neoplasia after a diagnosis of a hemosiderotic fibrohistiocytic lipomatous tumor in a 38-year-old woman, with two recurrences and later sarcomatous transformation. An immunohistochemical study indicated myofibroblastic differentiation of a malignant neoplasm. To the best of the authors’ knowledge, there are only few reported cases of malignant transformation in hemosiderotic fibrohistiocytic lipomatous tumors. |
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Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case reportHemosiderinHistiocytesAdipose tissueConnective tissueSarcomaABSTRACT Hemosiderotic fibrohistiocytic lipomatous tumors are rare neoplasms that were first described in 2000. Initially considered a benign lipotamous lesion of the soft tissues, nowadays they are considered to be a locally aggressive tumor. They occur mainly in the foot and ankle of women in their fifth and sixth decades, although they may be found in any place in the lower limbs and, more rarely, in other parts of the body. Histologically, hemosiderotic fibrohistiocytic lipomatous tumors consist of a mixture of mature adipose tissue, fusiform cell fascicles, macrophages that often contain cytoplasmic hemosiderin, mononuclear inflammatory infiltrate, and stroma that may be focally myxoid. Local recurrence is observed in nearly one-third of all cases. There is no consensus in the literature whether this tumor is a part of a spectrum that comprises pleomorphic hyalinizing angiectatic tumors and myxoinflammatory fibroblastic malignant tumors, or if it is an independent entity. The authors report a case of a neoplasia after a diagnosis of a hemosiderotic fibrohistiocytic lipomatous tumor in a 38-year-old woman, with two recurrences and later sarcomatous transformation. An immunohistochemical study indicated myofibroblastic differentiation of a malignant neoplasm. To the best of the authors’ knowledge, there are only few reported cases of malignant transformation in hemosiderotic fibrohistiocytic lipomatous tumors.Sociedade Brasileira de Ortopedia e Traumatologia2017-06-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000300366Revista Brasileira de Ortopedia v.52 n.3 2017reponame:Revista Brasileira de Ortopedia (Online)instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)instacron:SBOT10.1016/j.rboe.2016.11.002info:eu-repo/semantics/openAccessEtchebehere,Renata MargaridaAlmeida,Elia Cláudia SouzaSantos,Carlos David TeixeiraMicheletti,Adilha Misson RuaLeitão,Sebastião Almeidaeng2017-07-24T00:00:00Zoai:scielo:S0102-36162017000300366Revistahttp://www.rbo.org.br/https://old.scielo.br/oai/scielo-oai.php||rbo@sbot.org.br1982-43780102-3616opendoar:2017-07-24T00:00Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT)false |
dc.title.none.fl_str_mv |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
title |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
spellingShingle |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report Etchebehere,Renata Margarida Hemosiderin Histiocytes Adipose tissue Connective tissue Sarcoma |
title_short |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
title_full |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
title_fullStr |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
title_full_unstemmed |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
title_sort |
Sarcomatous transformation of a hemosiderotic fibrohistiocytic lipomatous tumor: a case report |
author |
Etchebehere,Renata Margarida |
author_facet |
Etchebehere,Renata Margarida Almeida,Elia Cláudia Souza Santos,Carlos David Teixeira Micheletti,Adilha Misson Rua Leitão,Sebastião Almeida |
author_role |
author |
author2 |
Almeida,Elia Cláudia Souza Santos,Carlos David Teixeira Micheletti,Adilha Misson Rua Leitão,Sebastião Almeida |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Etchebehere,Renata Margarida Almeida,Elia Cláudia Souza Santos,Carlos David Teixeira Micheletti,Adilha Misson Rua Leitão,Sebastião Almeida |
dc.subject.por.fl_str_mv |
Hemosiderin Histiocytes Adipose tissue Connective tissue Sarcoma |
topic |
Hemosiderin Histiocytes Adipose tissue Connective tissue Sarcoma |
description |
ABSTRACT Hemosiderotic fibrohistiocytic lipomatous tumors are rare neoplasms that were first described in 2000. Initially considered a benign lipotamous lesion of the soft tissues, nowadays they are considered to be a locally aggressive tumor. They occur mainly in the foot and ankle of women in their fifth and sixth decades, although they may be found in any place in the lower limbs and, more rarely, in other parts of the body. Histologically, hemosiderotic fibrohistiocytic lipomatous tumors consist of a mixture of mature adipose tissue, fusiform cell fascicles, macrophages that often contain cytoplasmic hemosiderin, mononuclear inflammatory infiltrate, and stroma that may be focally myxoid. Local recurrence is observed in nearly one-third of all cases. There is no consensus in the literature whether this tumor is a part of a spectrum that comprises pleomorphic hyalinizing angiectatic tumors and myxoinflammatory fibroblastic malignant tumors, or if it is an independent entity. The authors report a case of a neoplasia after a diagnosis of a hemosiderotic fibrohistiocytic lipomatous tumor in a 38-year-old woman, with two recurrences and later sarcomatous transformation. An immunohistochemical study indicated myofibroblastic differentiation of a malignant neoplasm. To the best of the authors’ knowledge, there are only few reported cases of malignant transformation in hemosiderotic fibrohistiocytic lipomatous tumors. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000300366 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162017000300366 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.rboe.2016.11.002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Ortopedia e Traumatologia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ortopedia v.52 n.3 2017 reponame:Revista Brasileira de Ortopedia (Online) instname:Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) instacron:SBOT |
instname_str |
Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
instacron_str |
SBOT |
institution |
SBOT |
reponame_str |
Revista Brasileira de Ortopedia (Online) |
collection |
Revista Brasileira de Ortopedia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Ortopedia (Online) - Sociedade Brasileira de Ortopedia e Traumatologia (SBOT) |
repository.mail.fl_str_mv |
||rbo@sbot.org.br |
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1752122360879644672 |