Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis

Bibliographic Details
Main Author: Moreira,Veronica Goulart
Publication Date: 2013
Other Authors: Canedo,Nathalie Henriques Silva, Chimelli,Leila Maria Cardão
Format: Article
Language: eng
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000300007
Summary: INTRODUCTION: Glial and neuroglial cell neoplasms comprise pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG), which share various similarities, though PA has better prognosis. As ganglion cells (GC) may be scarce in GG and these gangliogliomas may recur or progress to grade III, an accurate diagnosis is essential. OBJECTIVES: The aim was to identify GC and eosinophilic granular bodies (EGB) in PA and PXA, to evaluate its effect on patient’s outcome and compare them with GG. METHODS: A retrospective analysis of radiological, morphological and follow-up aspects (disease free-survival, recurrence and death) of 30 cases (14 PA, 8 PXA, 8 GG). Hematoxylin and eosin (HE) stained sections were reviewed to identify the presence of neoplastic GC and EGB. They were immunostained for synaptophysin (SYN) and neurofilament (NF). Glial fibrillary acidic protein (GFAP) immunostaining was performed in selected cases. RESULTS: Six PA were reclassified as GG due to the presence of GC by HE or immunohistochemistry. Some EGB resembling degenerate GC were also immunostained for SYN/NF and most of them were negative for GFAP. The mean disease-free survival was 62.16 months. Four tumors recurred and one patient died. All PXA had GC, suggesting that they were variants of GG, 4 of which recurred and one patient died. Mean disease-free survival was 69 months. The radiological aspect was predominantly cystic. CONCLUSION: We propose that PA and PXA with GC or with EGB immunopositive for neuronal markers could be variants of GG, and some EGB may represent degenerate GC. However, the presence of GC does not seem to modify the biological behavior of these neoplasms.
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spelling Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosispilocytic astrocytomapleomorphic xanthoastrocytomagangliogliomaganglion celleosinophilic granular bodiesclassificationINTRODUCTION: Glial and neuroglial cell neoplasms comprise pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG), which share various similarities, though PA has better prognosis. As ganglion cells (GC) may be scarce in GG and these gangliogliomas may recur or progress to grade III, an accurate diagnosis is essential. OBJECTIVES: The aim was to identify GC and eosinophilic granular bodies (EGB) in PA and PXA, to evaluate its effect on patient’s outcome and compare them with GG. METHODS: A retrospective analysis of radiological, morphological and follow-up aspects (disease free-survival, recurrence and death) of 30 cases (14 PA, 8 PXA, 8 GG). Hematoxylin and eosin (HE) stained sections were reviewed to identify the presence of neoplastic GC and EGB. They were immunostained for synaptophysin (SYN) and neurofilament (NF). Glial fibrillary acidic protein (GFAP) immunostaining was performed in selected cases. RESULTS: Six PA were reclassified as GG due to the presence of GC by HE or immunohistochemistry. Some EGB resembling degenerate GC were also immunostained for SYN/NF and most of them were negative for GFAP. The mean disease-free survival was 62.16 months. Four tumors recurred and one patient died. All PXA had GC, suggesting that they were variants of GG, 4 of which recurred and one patient died. Mean disease-free survival was 69 months. The radiological aspect was predominantly cystic. CONCLUSION: We propose that PA and PXA with GC or with EGB immunopositive for neuronal markers could be variants of GG, and some EGB may represent degenerate GC. However, the presence of GC does not seem to modify the biological behavior of these neoplasms.Sociedade Brasileira de Patologia Clínica2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000300007Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.3 2013reponame:Jornal Brasileiro de Patologia e Medicina Laboratorialinstname:Sociedade Brasileira de Patologia (SBP)instacron:SBP10.1590/S1676-24442013000300007info:eu-repo/semantics/openAccessMoreira,Veronica GoulartCanedo,Nathalie Henriques SilvaChimelli,Leila Maria Cardãoeng2013-08-29T00:00:00ZRevista
dc.title.none.fl_str_mv Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
title Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
spellingShingle Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
Moreira,Veronica Goulart
pilocytic astrocytoma
pleomorphic xanthoastrocytoma
ganglioglioma
ganglion cell
eosinophilic granular bodies
classification
title_short Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
title_full Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
title_fullStr Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
title_full_unstemmed Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
title_sort Ganglion cells in circumscribed astrocytic tumors: possible implication in classification and prognosis
author Moreira,Veronica Goulart
author_facet Moreira,Veronica Goulart
Canedo,Nathalie Henriques Silva
Chimelli,Leila Maria Cardão
author_role author
author2 Canedo,Nathalie Henriques Silva
Chimelli,Leila Maria Cardão
author2_role author
author
dc.contributor.author.fl_str_mv Moreira,Veronica Goulart
Canedo,Nathalie Henriques Silva
Chimelli,Leila Maria Cardão
dc.subject.por.fl_str_mv pilocytic astrocytoma
pleomorphic xanthoastrocytoma
ganglioglioma
ganglion cell
eosinophilic granular bodies
classification
topic pilocytic astrocytoma
pleomorphic xanthoastrocytoma
ganglioglioma
ganglion cell
eosinophilic granular bodies
classification
description INTRODUCTION: Glial and neuroglial cell neoplasms comprise pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma (PXA) and ganglioglioma (GG), which share various similarities, though PA has better prognosis. As ganglion cells (GC) may be scarce in GG and these gangliogliomas may recur or progress to grade III, an accurate diagnosis is essential. OBJECTIVES: The aim was to identify GC and eosinophilic granular bodies (EGB) in PA and PXA, to evaluate its effect on patient’s outcome and compare them with GG. METHODS: A retrospective analysis of radiological, morphological and follow-up aspects (disease free-survival, recurrence and death) of 30 cases (14 PA, 8 PXA, 8 GG). Hematoxylin and eosin (HE) stained sections were reviewed to identify the presence of neoplastic GC and EGB. They were immunostained for synaptophysin (SYN) and neurofilament (NF). Glial fibrillary acidic protein (GFAP) immunostaining was performed in selected cases. RESULTS: Six PA were reclassified as GG due to the presence of GC by HE or immunohistochemistry. Some EGB resembling degenerate GC were also immunostained for SYN/NF and most of them were negative for GFAP. The mean disease-free survival was 62.16 months. Four tumors recurred and one patient died. All PXA had GC, suggesting that they were variants of GG, 4 of which recurred and one patient died. Mean disease-free survival was 69 months. The radiological aspect was predominantly cystic. CONCLUSION: We propose that PA and PXA with GC or with EGB immunopositive for neuronal markers could be variants of GG, and some EGB may represent degenerate GC. However, the presence of GC does not seem to modify the biological behavior of these neoplasms.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000300007
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S1676-24442013000300007
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Sociedade Brasileira de Patologia Clínica
publisher.none.fl_str_mv
Sociedade Brasileira de Patologia Clínica
dc.source.none.fl_str_mv Jornal Brasileiro de Patologia e Medicina Laboratorial v.49 n.3 2013
reponame:Jornal Brasileiro de Patologia e Medicina Laboratorial
instname:Sociedade Brasileira de Patologia (SBP)
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reponame_str Jornal Brasileiro de Patologia e Medicina Laboratorial
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