Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Jornal de Pediatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100088 |
Resumo: | Abstract Objective: To assess the performance of cerebrospinal fluid (CSF) lactate as a biomarker to differentiate bacterial meningitis from viral meningitis in children, and to define an optimal CSF lactate concentration that can be called significant for the differentiation. Methods: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. Results: At a cut-off value of 3 mmol/L, CSF lactate had a sensitivity of 0.90, specificity of 1.0, positive predictive value of 1.0, and negative predictive value of 0.963, with an accuracy of 0.972. The positive and negative likelihood ratios were 23.6 and 0.1, respectively. When comparing between bacterial and viral meningitis, the area under the curve for CSF lactate was 0.979. Conclusions: The authors concluded that CSF lactate has high sensitivity and specificity in differentiating bacterial from viral meningitis. While at a cut-off value of 3 mmol/L, CSF lactate has high diagnostic accuracy for bacterial meningitis, mean levels in viral meningitis remain essentially below 2 mmol/L. |
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Jornal de Pediatria (Online) |
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spelling |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in childrenCSF culturePneumococcal meningitisCSF markersAbstract Objective: To assess the performance of cerebrospinal fluid (CSF) lactate as a biomarker to differentiate bacterial meningitis from viral meningitis in children, and to define an optimal CSF lactate concentration that can be called significant for the differentiation. Methods: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. Results: At a cut-off value of 3 mmol/L, CSF lactate had a sensitivity of 0.90, specificity of 1.0, positive predictive value of 1.0, and negative predictive value of 0.963, with an accuracy of 0.972. The positive and negative likelihood ratios were 23.6 and 0.1, respectively. When comparing between bacterial and viral meningitis, the area under the curve for CSF lactate was 0.979. Conclusions: The authors concluded that CSF lactate has high sensitivity and specificity in differentiating bacterial from viral meningitis. While at a cut-off value of 3 mmol/L, CSF lactate has high diagnostic accuracy for bacterial meningitis, mean levels in viral meningitis remain essentially below 2 mmol/L.Sociedade Brasileira de Pediatria2018-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100088Jornal de Pediatria v.94 n.1 2018reponame:Jornal de Pediatria (Online)instname:Sociedade Brasileira de Pediatria (SBP)instacron:SBPE10.1016/j.jped.2017.03.007info:eu-repo/semantics/openAccessNazir,MudasirWani,Wasim AhmadMalik,Muzaffar AhmadMir,Mohd RafiqAshraf,YounisKawoosa,KhalidAli,Syed Wajideng2018-03-01T00:00:00Zoai:scielo:S0021-75572018000100088Revistahttp://www.jped.com.br/https://old.scielo.br/oai/scielo-oai.php||jped@jped.com.br1678-47820021-7557opendoar:2018-03-01T00:00Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP)false |
dc.title.none.fl_str_mv |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
title |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
spellingShingle |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children Nazir,Mudasir CSF culture Pneumococcal meningitis CSF markers |
title_short |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
title_full |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
title_fullStr |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
title_full_unstemmed |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
title_sort |
Cerebrospinal fluid lactate: a differential biomarker for bacterial and viral meningitis in children |
author |
Nazir,Mudasir |
author_facet |
Nazir,Mudasir Wani,Wasim Ahmad Malik,Muzaffar Ahmad Mir,Mohd Rafiq Ashraf,Younis Kawoosa,Khalid Ali,Syed Wajid |
author_role |
author |
author2 |
Wani,Wasim Ahmad Malik,Muzaffar Ahmad Mir,Mohd Rafiq Ashraf,Younis Kawoosa,Khalid Ali,Syed Wajid |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Nazir,Mudasir Wani,Wasim Ahmad Malik,Muzaffar Ahmad Mir,Mohd Rafiq Ashraf,Younis Kawoosa,Khalid Ali,Syed Wajid |
dc.subject.por.fl_str_mv |
CSF culture Pneumococcal meningitis CSF markers |
topic |
CSF culture Pneumococcal meningitis CSF markers |
description |
Abstract Objective: To assess the performance of cerebrospinal fluid (CSF) lactate as a biomarker to differentiate bacterial meningitis from viral meningitis in children, and to define an optimal CSF lactate concentration that can be called significant for the differentiation. Methods: Children with clinical findings compatible with meningitis were studied. CSF lactate and other conventional CSF parameters were recorded. Results: At a cut-off value of 3 mmol/L, CSF lactate had a sensitivity of 0.90, specificity of 1.0, positive predictive value of 1.0, and negative predictive value of 0.963, with an accuracy of 0.972. The positive and negative likelihood ratios were 23.6 and 0.1, respectively. When comparing between bacterial and viral meningitis, the area under the curve for CSF lactate was 0.979. Conclusions: The authors concluded that CSF lactate has high sensitivity and specificity in differentiating bacterial from viral meningitis. While at a cut-off value of 3 mmol/L, CSF lactate has high diagnostic accuracy for bacterial meningitis, mean levels in viral meningitis remain essentially below 2 mmol/L. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100088 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572018000100088 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.jped.2017.03.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pediatria |
dc.source.none.fl_str_mv |
Jornal de Pediatria v.94 n.1 2018 reponame:Jornal de Pediatria (Online) instname:Sociedade Brasileira de Pediatria (SBP) instacron:SBPE |
instname_str |
Sociedade Brasileira de Pediatria (SBP) |
instacron_str |
SBPE |
institution |
SBPE |
reponame_str |
Jornal de Pediatria (Online) |
collection |
Jornal de Pediatria (Online) |
repository.name.fl_str_mv |
Jornal de Pediatria (Online) - Sociedade Brasileira de Pediatria (SBP) |
repository.mail.fl_str_mv |
||jped@jped.com.br |
_version_ |
1752122321351475200 |