Risk factors for jaw osteoradionecrosis: a case control study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Oral Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242022000100312 |
Resumo: | Abstract There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development. |
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Brazilian Oral Research |
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Risk factors for jaw osteoradionecrosis: a case control studyRisk FactorsOsteoradionecrosisCase-Control StudiesMouth NeoplasmsAbstract There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development.Sociedade Brasileira de Pesquisa Odontológica - SBPqO2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242022000100312Brazilian Oral Research v.36 2022reponame:Brazilian Oral Researchinstname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO)instacron:SBPQO10.1590/1807-3107bor-2022.vol36.0132info:eu-repo/semantics/openAccessGIRARDI,Fábio MuradásWAGNER,Vivian PetersenMARTINS,Manoela DominguesABENTROTH,Aliende LenglerHAUTH,Luiz AlbertoKRAETHER NETO,LeoMERGEN,CristianMATIELLO,Julianaeng2022-11-07T00:00:00Zoai:scielo:S1806-83242022000100312Revistahttps://www.scielo.br/j/bor/https://old.scielo.br/oai/scielo-oai.phppob@edu.usp.br||bor@sbpqo.org.br1807-31071806-8324opendoar:2022-11-07T00:00Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO)false |
dc.title.none.fl_str_mv |
Risk factors for jaw osteoradionecrosis: a case control study |
title |
Risk factors for jaw osteoradionecrosis: a case control study |
spellingShingle |
Risk factors for jaw osteoradionecrosis: a case control study GIRARDI,Fábio Muradás Risk Factors Osteoradionecrosis Case-Control Studies Mouth Neoplasms |
title_short |
Risk factors for jaw osteoradionecrosis: a case control study |
title_full |
Risk factors for jaw osteoradionecrosis: a case control study |
title_fullStr |
Risk factors for jaw osteoradionecrosis: a case control study |
title_full_unstemmed |
Risk factors for jaw osteoradionecrosis: a case control study |
title_sort |
Risk factors for jaw osteoradionecrosis: a case control study |
author |
GIRARDI,Fábio Muradás |
author_facet |
GIRARDI,Fábio Muradás WAGNER,Vivian Petersen MARTINS,Manoela Domingues ABENTROTH,Aliende Lengler HAUTH,Luiz Alberto KRAETHER NETO,Leo MERGEN,Cristian MATIELLO,Juliana |
author_role |
author |
author2 |
WAGNER,Vivian Petersen MARTINS,Manoela Domingues ABENTROTH,Aliende Lengler HAUTH,Luiz Alberto KRAETHER NETO,Leo MERGEN,Cristian MATIELLO,Juliana |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
GIRARDI,Fábio Muradás WAGNER,Vivian Petersen MARTINS,Manoela Domingues ABENTROTH,Aliende Lengler HAUTH,Luiz Alberto KRAETHER NETO,Leo MERGEN,Cristian MATIELLO,Juliana |
dc.subject.por.fl_str_mv |
Risk Factors Osteoradionecrosis Case-Control Studies Mouth Neoplasms |
topic |
Risk Factors Osteoradionecrosis Case-Control Studies Mouth Neoplasms |
description |
Abstract There are divergences among studies regarding features associated to increased risk of osteoradionecrosis (ORN). Our objective was to identify factors that predispose to the development of ORN of the jaw. This was a retrospective, hospital-based, case-control study involving patients with head and neck cancer who had been treated with ≥ 60 Gy external radiotherapy (RT) to the jaw. A total of 19 cases of ORN and 43 controls were included. The patients’ demographic data, tumor type, staging, treatment and outcome information, and pre-treatment oral status were collected. Univariate analysis showed that the oral cavity/oropharynx sites were associated with 9.77-fold increased risk of ORN development compared to other sites (p = 0.005). Being an active smoker was associated with 3.95-fold increased risk of ORN development (p = 0.01). A tendency towards increased risk of ORN was observed particularly when tooth extraction occurred after RT (odds ratio (OR): 3.04; p = 0.08). Multivariable analysis showed that tumor site was the only significant risk factor (OR: 21.03, p = 0.01). The oral and oropharyngeal primary site is an important risk factor for ORN. Dental extraction, which did not occur in 28% of the sample, was not an essential event for ORN development. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242022000100312 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242022000100312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1807-3107bor-2022.vol36.0132 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
publisher.none.fl_str_mv |
Sociedade Brasileira de Pesquisa Odontológica - SBPqO |
dc.source.none.fl_str_mv |
Brazilian Oral Research v.36 2022 reponame:Brazilian Oral Research instname:Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO |
instname_str |
Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
instacron_str |
SBPQO |
institution |
SBPQO |
reponame_str |
Brazilian Oral Research |
collection |
Brazilian Oral Research |
repository.name.fl_str_mv |
Brazilian Oral Research - Sociedade Brasileira de Pesquisa Odontológica (SBPqO) |
repository.mail.fl_str_mv |
pob@edu.usp.br||bor@sbpqo.org.br |
_version_ |
1750318328525619200 |