Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300011 |
Resumo: | This work reports the simultaneous determination of paracetamol and naproxen using multiple-pulse amperometric detection on a multi-walled carbon nanotube modified screen-printed electrode (MWCNT-SPE) adapted in a homemade flow-injection analysis (FIA) cell. A sequence of two potential pulses (+0.30 and +0.70 V for 70 ms each) was applied continuously in such a way that paracetamol is selectively oxidized at +0.30 V and both compounds (paracetamol and naproxen) are oxidized at +0.70 V. Current subtraction after using a correction factor was employed for determination of naproxen without the interference of paracetamol. The proposed FIA method presents high selectivity and sensitivity, adequate accuracy (results in agreement with high-performance liquid chromatography), elevated analytical frequency (90 h-1), and low-cost once a single SPE strip can be used during the whole working day adapted in a flow-cell. |
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Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodescarbon nanotubespharmaceutical formulationsflow analysisacetaminophennon-steroidal anti-inflammatory drugThis work reports the simultaneous determination of paracetamol and naproxen using multiple-pulse amperometric detection on a multi-walled carbon nanotube modified screen-printed electrode (MWCNT-SPE) adapted in a homemade flow-injection analysis (FIA) cell. A sequence of two potential pulses (+0.30 and +0.70 V for 70 ms each) was applied continuously in such a way that paracetamol is selectively oxidized at +0.30 V and both compounds (paracetamol and naproxen) are oxidized at +0.70 V. Current subtraction after using a correction factor was employed for determination of naproxen without the interference of paracetamol. The proposed FIA method presents high selectivity and sensitivity, adequate accuracy (results in agreement with high-performance liquid chromatography), elevated analytical frequency (90 h-1), and low-cost once a single SPE strip can be used during the whole working day adapted in a flow-cell.Sociedade Brasileira de Química2014-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300011Journal of the Brazilian Chemical Society v.25 n.3 2014reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20140006info:eu-repo/semantics/openAccessStefano,Jessica S.Montes,Rodrigo H. O.Richter,Eduardo M.Muñoz,Rodrigo A. A.eng2014-03-19T00:00:00Zoai:scielo:S0103-50532014000300011Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2014-03-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
title |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
spellingShingle |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes Stefano,Jessica S. carbon nanotubes pharmaceutical formulations flow analysis acetaminophen non-steroidal anti-inflammatory drug |
title_short |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
title_full |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
title_fullStr |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
title_full_unstemmed |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
title_sort |
Flow-injection analysis with multiple-pulse amperometry for simultaneous determination of paracetamol and naproxen using a homemade flow cell for screen-printed electrodes |
author |
Stefano,Jessica S. |
author_facet |
Stefano,Jessica S. Montes,Rodrigo H. O. Richter,Eduardo M. Muñoz,Rodrigo A. A. |
author_role |
author |
author2 |
Montes,Rodrigo H. O. Richter,Eduardo M. Muñoz,Rodrigo A. A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Stefano,Jessica S. Montes,Rodrigo H. O. Richter,Eduardo M. Muñoz,Rodrigo A. A. |
dc.subject.por.fl_str_mv |
carbon nanotubes pharmaceutical formulations flow analysis acetaminophen non-steroidal anti-inflammatory drug |
topic |
carbon nanotubes pharmaceutical formulations flow analysis acetaminophen non-steroidal anti-inflammatory drug |
description |
This work reports the simultaneous determination of paracetamol and naproxen using multiple-pulse amperometric detection on a multi-walled carbon nanotube modified screen-printed electrode (MWCNT-SPE) adapted in a homemade flow-injection analysis (FIA) cell. A sequence of two potential pulses (+0.30 and +0.70 V for 70 ms each) was applied continuously in such a way that paracetamol is selectively oxidized at +0.30 V and both compounds (paracetamol and naproxen) are oxidized at +0.70 V. Current subtraction after using a correction factor was employed for determination of naproxen without the interference of paracetamol. The proposed FIA method presents high selectivity and sensitivity, adequate accuracy (results in agreement with high-performance liquid chromatography), elevated analytical frequency (90 h-1), and low-cost once a single SPE strip can be used during the whole working day adapted in a flow-cell. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014000300011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5935/0103-5053.20140006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.25 n.3 2014 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
_version_ |
1750318175745998848 |