New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole

Detalhes bibliográficos
Autor(a) principal: Lima,Lídia M.
Data de Publicação: 1999
Outros Autores: Ormelli,Claudia B., Fraga,Carlos A.M., Miranda,Ana L.P., Barreiro,Eliezer J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013
Resumo: As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
id SBQ-2_45987bca323b4379e04d41e36f52486b
oai_identifier_str oai:scielo:S0103-50531999000500013
network_acronym_str SBQ-2
network_name_str Journal of the Brazilian Chemical Society (Online)
repository_id_str
spelling New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrolesafrole in synthesisphenylsulfonylthiosemicarbazide derivativeantithrombotic activityAs part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.Sociedade Brasileira de Química1999-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013Journal of the Brazilian Chemical Society v.10 n.5 1999reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50531999000500013info:eu-repo/semantics/openAccessLima,Lídia M.Ormelli,Claudia B.Fraga,Carlos A.M.Miranda,Ana L.P.Barreiro,Eliezer J.eng2001-06-07T00:00:00Zoai:scielo:S0103-50531999000500013Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2001-06-07T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
title New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
spellingShingle New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
Lima,Lídia M.
safrole in synthesis
phenylsulfonylthiosemicarbazide derivative
antithrombotic activity
title_short New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
title_full New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
title_fullStr New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
title_full_unstemmed New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
title_sort New antithrombotic aryl-sulfonylthiosemicarbazide derivatives synthesized from natural safrole
author Lima,Lídia M.
author_facet Lima,Lídia M.
Ormelli,Claudia B.
Fraga,Carlos A.M.
Miranda,Ana L.P.
Barreiro,Eliezer J.
author_role author
author2 Ormelli,Claudia B.
Fraga,Carlos A.M.
Miranda,Ana L.P.
Barreiro,Eliezer J.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima,Lídia M.
Ormelli,Claudia B.
Fraga,Carlos A.M.
Miranda,Ana L.P.
Barreiro,Eliezer J.
dc.subject.por.fl_str_mv safrole in synthesis
phenylsulfonylthiosemicarbazide derivative
antithrombotic activity
topic safrole in synthesis
phenylsulfonylthiosemicarbazide derivative
antithrombotic activity
description As part of a research program aiming at the synthesis and pharmacological evaluation of novel lead-compounds exploring Brazilian abundant natural products, we describe herein the synthesis and the antithrombotic profile of new aryl-sulfonylsemicarbazides and aryl-sulfonylthiosemicarbazides (10a-d). The new derivatives, designed with basis on the molecular hybridization concept, were prepared in good yields from natural safrole (9), isolated from sassafras oil. The anti-aggregating activity of these new derivatives (10a-d) on platelet aggregation induced by ADP, collagen, arachidonic acid and U-46619, indicates an important antithrombotic profile for the 6-methyl-3,4-methylenedioxyphenyl-sulfonyl-N-phenylthiosemicarbazide derivative (10d), acting at the arachidonic acid cascade and representing a new lead-compound with antithrombotic activity.
publishDate 1999
dc.date.none.fl_str_mv 1999-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50531999000500013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.10 n.5 1999
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
_version_ 1750318163803766784

Registros relacionados