Turning Metabolomics into Drug Discovery

Detalhes bibliográficos
Autor(a) principal: Boufridi,Asmaa
Data de Publicação: 2016
Outros Autores: Quinn,Ronald J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801334
Resumo: Metabolomics is the "omics" that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We believe that coupling metabolomic studies with standards of known physicochemical properties in order to calibrate the chromatographic columns can be beneficial in identifying compounds of candidate drug quality.
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spelling Turning Metabolomics into Drug Discoverynatural productsHPLCretention timelog PdruggabilityMetabolomics is the "omics" that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We believe that coupling metabolomic studies with standards of known physicochemical properties in order to calibrate the chromatographic columns can be beneficial in identifying compounds of candidate drug quality.Sociedade Brasileira de Química2016-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801334Journal of the Brazilian Chemical Society v.27 n.8 2016reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0103-5053.20160083info:eu-repo/semantics/openAccessBoufridi,AsmaaQuinn,Ronald J.eng2016-08-19T00:00:00Zoai:scielo:S0103-50532016000801334Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2016-08-19T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Turning Metabolomics into Drug Discovery
title Turning Metabolomics into Drug Discovery
spellingShingle Turning Metabolomics into Drug Discovery
Boufridi,Asmaa
natural products
HPLC
retention time
log P
druggability
title_short Turning Metabolomics into Drug Discovery
title_full Turning Metabolomics into Drug Discovery
title_fullStr Turning Metabolomics into Drug Discovery
title_full_unstemmed Turning Metabolomics into Drug Discovery
title_sort Turning Metabolomics into Drug Discovery
author Boufridi,Asmaa
author_facet Boufridi,Asmaa
Quinn,Ronald J.
author_role author
author2 Quinn,Ronald J.
author2_role author
dc.contributor.author.fl_str_mv Boufridi,Asmaa
Quinn,Ronald J.
dc.subject.por.fl_str_mv natural products
HPLC
retention time
log P
druggability
topic natural products
HPLC
retention time
log P
druggability
description Metabolomics is the "omics" that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We believe that coupling metabolomic studies with standards of known physicochemical properties in order to calibrate the chromatographic columns can be beneficial in identifying compounds of candidate drug quality.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801334
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532016000801334
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0103-5053.20160083
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.27 n.8 2016
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
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instname_str Sociedade Brasileira de Química (SBQ)
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reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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