Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Journal of the Brazilian Chemical Society (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801494 |
Resumo: | The aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulation study was carried out using a 24-1 fractional factorial design. Microparticles were prepared using the double w/o/w emulsion-solvent evaporation method. The coencapsulated t-DCTN:HP-β-CD-loaded PLGA microparticles (t-DCTN/t-DCTN:HP-β-CD/PLGA-MPs) presented a smaller particle size (9.6 ± 0.1 µm) and higher drug loading (13.93 ± 0.05%, corresponding to 90.1 ± 0.3% of encapsulation efficiency, EE) and t-DCTN-loaded PLGA microparticles (t-DCTN/PLGA-MPs) presented particle size of 37.0 ± 0.2 µm and drug loading of 10.12 ± 0.01% (EE of 71.2 ± 0.1%). The coencapsulation of t-DCTN and t-DCTN:HP-β-CD into PLGA microparticles increased drug loading (50%) and improved the drug controlled release (k2 = 0.0475 and De = 0.0475 × 10-11 cm2 s-1). Taking into account these findings, new oral formulation of PLGA microparticles containing coencapsulated t-DCTN and t-DCTN:HP-β-CD are available as biocompatible drug delivery systems for further pharmacological purposes. |
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Journal of the Brazilian Chemical Society (Online) |
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Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticlestrans-dehydrocrotonincyclodextrinPLGA microparticlescoencapsulationfractional factorial designThe aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulation study was carried out using a 24-1 fractional factorial design. Microparticles were prepared using the double w/o/w emulsion-solvent evaporation method. The coencapsulated t-DCTN:HP-β-CD-loaded PLGA microparticles (t-DCTN/t-DCTN:HP-β-CD/PLGA-MPs) presented a smaller particle size (9.6 ± 0.1 µm) and higher drug loading (13.93 ± 0.05%, corresponding to 90.1 ± 0.3% of encapsulation efficiency, EE) and t-DCTN-loaded PLGA microparticles (t-DCTN/PLGA-MPs) presented particle size of 37.0 ± 0.2 µm and drug loading of 10.12 ± 0.01% (EE of 71.2 ± 0.1%). The coencapsulation of t-DCTN and t-DCTN:HP-β-CD into PLGA microparticles increased drug loading (50%) and improved the drug controlled release (k2 = 0.0475 and De = 0.0475 × 10-11 cm2 s-1). Taking into account these findings, new oral formulation of PLGA microparticles containing coencapsulated t-DCTN and t-DCTN:HP-β-CD are available as biocompatible drug delivery systems for further pharmacological purposes.Sociedade Brasileira de Química2017-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801494Journal of the Brazilian Chemical Society v.28 n.8 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160331info:eu-repo/semantics/openAccessMorais,Waldenice A.Barros Neto,Benício deCavalcanti,Isabella M. F.Xavier Junior,Francisco H.Santos-Magalhães,Nereide S.Maciel,Maria Aparecida M.eng2017-07-18T00:00:00Zoai:scielo:S0103-50532017000801494Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-07-18T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false |
dc.title.none.fl_str_mv |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
title |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
spellingShingle |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles Morais,Waldenice A. trans-dehydrocrotonin cyclodextrin PLGA microparticles coencapsulation fractional factorial design |
title_short |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
title_full |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
title_fullStr |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
title_full_unstemmed |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
title_sort |
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles |
author |
Morais,Waldenice A. |
author_facet |
Morais,Waldenice A. Barros Neto,Benício de Cavalcanti,Isabella M. F. Xavier Junior,Francisco H. Santos-Magalhães,Nereide S. Maciel,Maria Aparecida M. |
author_role |
author |
author2 |
Barros Neto,Benício de Cavalcanti,Isabella M. F. Xavier Junior,Francisco H. Santos-Magalhães,Nereide S. Maciel,Maria Aparecida M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Morais,Waldenice A. Barros Neto,Benício de Cavalcanti,Isabella M. F. Xavier Junior,Francisco H. Santos-Magalhães,Nereide S. Maciel,Maria Aparecida M. |
dc.subject.por.fl_str_mv |
trans-dehydrocrotonin cyclodextrin PLGA microparticles coencapsulation fractional factorial design |
topic |
trans-dehydrocrotonin cyclodextrin PLGA microparticles coencapsulation fractional factorial design |
description |
The aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulation study was carried out using a 24-1 fractional factorial design. Microparticles were prepared using the double w/o/w emulsion-solvent evaporation method. The coencapsulated t-DCTN:HP-β-CD-loaded PLGA microparticles (t-DCTN/t-DCTN:HP-β-CD/PLGA-MPs) presented a smaller particle size (9.6 ± 0.1 µm) and higher drug loading (13.93 ± 0.05%, corresponding to 90.1 ± 0.3% of encapsulation efficiency, EE) and t-DCTN-loaded PLGA microparticles (t-DCTN/PLGA-MPs) presented particle size of 37.0 ± 0.2 µm and drug loading of 10.12 ± 0.01% (EE of 71.2 ± 0.1%). The coencapsulation of t-DCTN and t-DCTN:HP-β-CD into PLGA microparticles increased drug loading (50%) and improved the drug controlled release (k2 = 0.0475 and De = 0.0475 × 10-11 cm2 s-1). Taking into account these findings, new oral formulation of PLGA microparticles containing coencapsulated t-DCTN and t-DCTN:HP-β-CD are available as biocompatible drug delivery systems for further pharmacological purposes. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801494 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000801494 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.21577/0103-5053.20160331 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
Journal of the Brazilian Chemical Society v.28 n.8 2017 reponame:Journal of the Brazilian Chemical Society (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
instname_str |
Sociedade Brasileira de Química (SBQ) |
instacron_str |
SBQ |
institution |
SBQ |
reponame_str |
Journal of the Brazilian Chemical Society (Online) |
collection |
Journal of the Brazilian Chemical Society (Online) |
repository.name.fl_str_mv |
Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ) |
repository.mail.fl_str_mv |
||office@jbcs.sbq.org.br |
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1750318179911991296 |