First Asymmetric Reduction of Isatin by Marine-Derived Fungi

Detalhes bibliográficos
Autor(a) principal: Birolli,Willian G.
Data de Publicação: 2017
Outros Autores: Ferrreira,Irlon M., Jimenez,David E. Q., Silva,Bianca N. M., Silva,Bárbara V., Pinto,Angelo C., Porto,André L. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601023
Resumo: In this study, whole cells of marine-derived fungi were used to reduce isatin (1H-indole-2,3-dione) to dioxindole (3-hydroxyindolin-2-one) for 7 days at 32 °C. The screening showed that several strains could reduce isatin and produce the enantioenriched dioxindole. The best conversions were obtained by Cladosporium sp. CBMAI 1237 and Westerdykella sp. CBMAI 1679, however, the best enantiomeric excess was obtained only by Aspergillus sydowii CBMAI 935 (66% ee). In conclusion, marine-derived fungi show potential for asymmetric and chemoselective reduction of isatin (1H-indole-2,3-dione).
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spelling First Asymmetric Reduction of Isatin by Marine-Derived Fungiwhole cellsmarine fungibiocatalysischemoselective reactionIn this study, whole cells of marine-derived fungi were used to reduce isatin (1H-indole-2,3-dione) to dioxindole (3-hydroxyindolin-2-one) for 7 days at 32 °C. The screening showed that several strains could reduce isatin and produce the enantioenriched dioxindole. The best conversions were obtained by Cladosporium sp. CBMAI 1237 and Westerdykella sp. CBMAI 1679, however, the best enantiomeric excess was obtained only by Aspergillus sydowii CBMAI 935 (66% ee). In conclusion, marine-derived fungi show potential for asymmetric and chemoselective reduction of isatin (1H-indole-2,3-dione).Sociedade Brasileira de Química2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601023Journal of the Brazilian Chemical Society v.28 n.6 2017reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.21577/0103-5053.20160256info:eu-repo/semantics/openAccessBirolli,Willian G.Ferrreira,Irlon M.Jimenez,David E. Q.Silva,Bianca N. M.Silva,Bárbara V.Pinto,Angelo C.Porto,André L. M.eng2017-05-11T00:00:00Zoai:scielo:S0103-50532017000601023Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2017-05-11T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv First Asymmetric Reduction of Isatin by Marine-Derived Fungi
title First Asymmetric Reduction of Isatin by Marine-Derived Fungi
spellingShingle First Asymmetric Reduction of Isatin by Marine-Derived Fungi
Birolli,Willian G.
whole cells
marine fungi
biocatalysis
chemoselective reaction
title_short First Asymmetric Reduction of Isatin by Marine-Derived Fungi
title_full First Asymmetric Reduction of Isatin by Marine-Derived Fungi
title_fullStr First Asymmetric Reduction of Isatin by Marine-Derived Fungi
title_full_unstemmed First Asymmetric Reduction of Isatin by Marine-Derived Fungi
title_sort First Asymmetric Reduction of Isatin by Marine-Derived Fungi
author Birolli,Willian G.
author_facet Birolli,Willian G.
Ferrreira,Irlon M.
Jimenez,David E. Q.
Silva,Bianca N. M.
Silva,Bárbara V.
Pinto,Angelo C.
Porto,André L. M.
author_role author
author2 Ferrreira,Irlon M.
Jimenez,David E. Q.
Silva,Bianca N. M.
Silva,Bárbara V.
Pinto,Angelo C.
Porto,André L. M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Birolli,Willian G.
Ferrreira,Irlon M.
Jimenez,David E. Q.
Silva,Bianca N. M.
Silva,Bárbara V.
Pinto,Angelo C.
Porto,André L. M.
dc.subject.por.fl_str_mv whole cells
marine fungi
biocatalysis
chemoselective reaction
topic whole cells
marine fungi
biocatalysis
chemoselective reaction
description In this study, whole cells of marine-derived fungi were used to reduce isatin (1H-indole-2,3-dione) to dioxindole (3-hydroxyindolin-2-one) for 7 days at 32 °C. The screening showed that several strains could reduce isatin and produce the enantioenriched dioxindole. The best conversions were obtained by Cladosporium sp. CBMAI 1237 and Westerdykella sp. CBMAI 1679, however, the best enantiomeric excess was obtained only by Aspergillus sydowii CBMAI 935 (66% ee). In conclusion, marine-derived fungi show potential for asymmetric and chemoselective reduction of isatin (1H-indole-2,3-dione).
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532017000601023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.21577/0103-5053.20160256
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.28 n.6 2017
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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