New Alkaloids from Margaritopsis carrascoana (Rubiaceae)

• Autor(a) principal: Nascimento,Raimundo R. G.
• Data de Publicação: 2015
• Outros Autores: Pimenta,Antônia T. A., Lima Neto,Pedro de, C. Junior,José R., Costa-Lotufo,Letícia V., Ferreira,Elthon G., Tinoco,Luzineide W., Braz-Filho,Raimundo, Silveira,Edilberto R., Lima,Mary A. S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of the Brazilian Chemical Society (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000601152
• topic: Margaritopsis carrascoana; Rubiaceae alkaloids; N-8”-methyl-N-1’-demethyliso-calycosidine; N-8”-formyl-calycosidine; calycosidine; hodgkinsine

Two new alkaloids containing Nb-methyl-triptamine units linked to bis-quinoline moieties, N-8”-formyl-calycosidine and N-8”-methyl-N-1’-demethyl-iso-calycosidine, were isolated from the aerial part of Margaritopsis carrascoana, along with known calycosidine and hodgkinsine. The cytotoxicity of the isolated alkaloids has been evaluated against cancer cell lines. The first two compounds showed only weak activity against HL-60 cell line, while hodgkinsine was the most active compound against HCT-116, OVCAR-8, HL-60 and SF-295 cancer cell lines. The structures of the isolated compounds were established by spectroscopic and molecular mechanical methods.