CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS

Detalhes bibliográficos
Autor(a) principal: Leal,Claudenete Vieira
Data de Publicação: 2015
Outros Autores: Martinez,Diego Stéfani Teodoro, Espósito,Andréa Rodrigues, Más,Bruna Antunes, Moraes,Ana Carolina Mazarin, Alves,Oswaldo Luiz, Duek,Eliana Aparecida Rezende de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901153
Resumo: Carbon nanotubes (CNT) have been studied for biomedical applications due to their unique properties. However, pristine CNT have structural features and impurities that can cause toxicity to biological systems. In this work, we describe a method to purify multiwalled carbon nanotubes (MWCNT) by chemical modification and subsequent attachment of hydroxyl and carboxyl groups to improve dispersion and to decrease toxic effects. Nanocomposites from poly (L-lactic acid) (PLLA) and nanotubes were produced by the solvent casting method and characterized and evaluated for cytocompatibility with Vero cells. The nanocomposite interactions with Vero cells demonstrated that the cells were able to adhere and sustain proliferation and showed favorable cytocompatibility. In vitro studies also revealed an increase in fibroblast cell viability in the nanocomposites, compared with neat PLLA.
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spelling CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOScarbon nanotubesnanocompositesPLLAcytocompatibility, toxicityCarbon nanotubes (CNT) have been studied for biomedical applications due to their unique properties. However, pristine CNT have structural features and impurities that can cause toxicity to biological systems. In this work, we describe a method to purify multiwalled carbon nanotubes (MWCNT) by chemical modification and subsequent attachment of hydroxyl and carboxyl groups to improve dispersion and to decrease toxic effects. Nanocomposites from poly (L-lactic acid) (PLLA) and nanotubes were produced by the solvent casting method and characterized and evaluated for cytocompatibility with Vero cells. The nanocomposite interactions with Vero cells demonstrated that the cells were able to adhere and sustain proliferation and showed favorable cytocompatibility. In vitro studies also revealed an increase in fibroblast cell viability in the nanocomposites, compared with neat PLLA.Sociedade Brasileira de Química2015-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901153Química Nova v.38 n.9 2015reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.5935/0100-4042.20150132info:eu-repo/semantics/openAccessLeal,Claudenete VieiraMartinez,Diego Stéfani TeodoroEspósito,Andréa RodriguesMás,Bruna AntunesMoraes,Ana Carolina MazarinAlves,Oswaldo LuizDuek,Eliana Aparecida Rezende depor2015-12-01T00:00:00Zoai:scielo:S0100-40422015000901153Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2015-12-01T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
title CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
spellingShingle CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
Leal,Claudenete Vieira
carbon nanotubes
nanocomposites
PLLA
cytocompatibility, toxicity
title_short CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
title_full CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
title_fullStr CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
title_full_unstemmed CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
title_sort CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
author Leal,Claudenete Vieira
author_facet Leal,Claudenete Vieira
Martinez,Diego Stéfani Teodoro
Espósito,Andréa Rodrigues
Más,Bruna Antunes
Moraes,Ana Carolina Mazarin
Alves,Oswaldo Luiz
Duek,Eliana Aparecida Rezende de
author_role author
author2 Martinez,Diego Stéfani Teodoro
Espósito,Andréa Rodrigues
Más,Bruna Antunes
Moraes,Ana Carolina Mazarin
Alves,Oswaldo Luiz
Duek,Eliana Aparecida Rezende de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leal,Claudenete Vieira
Martinez,Diego Stéfani Teodoro
Espósito,Andréa Rodrigues
Más,Bruna Antunes
Moraes,Ana Carolina Mazarin
Alves,Oswaldo Luiz
Duek,Eliana Aparecida Rezende de
dc.subject.por.fl_str_mv carbon nanotubes
nanocomposites
PLLA
cytocompatibility, toxicity
topic carbon nanotubes
nanocomposites
PLLA
cytocompatibility, toxicity
description Carbon nanotubes (CNT) have been studied for biomedical applications due to their unique properties. However, pristine CNT have structural features and impurities that can cause toxicity to biological systems. In this work, we describe a method to purify multiwalled carbon nanotubes (MWCNT) by chemical modification and subsequent attachment of hydroxyl and carboxyl groups to improve dispersion and to decrease toxic effects. Nanocomposites from poly (L-lactic acid) (PLLA) and nanotubes were produced by the solvent casting method and characterized and evaluated for cytocompatibility with Vero cells. The nanocomposite interactions with Vero cells demonstrated that the cells were able to adhere and sustain proliferation and showed favorable cytocompatibility. In vitro studies also revealed an increase in fibroblast cell viability in the nanocomposites, compared with neat PLLA.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901153
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901153
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.5935/0100-4042.20150132
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.38 n.9 2015
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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