Multisystem Inflammatory Syndrome in Children: sectional study of cases and factors associated with deaths during COVID-19 pandemic in Brazil, 2020

• Autor(a) principal: de Almeida Relvas-Brandt, Laís
• Data de Publicação: 2021
• Outros Autores: Gava, Caroline, Sindeaux Camelo, Fernanda, Bertollo Gomes Porto, Victor, Fernandes Santos Alves, Ronaldo, Santos Correa Da Costa, Marcela, Maria Deotti Carvalho, Sandra, Madeleine Ikeda do Carmo, Greice, Fontana Sutile Tardetti Fantinato, Francieli, Yoshito Wada, Marcelo, Myrna Meneses Brandão e Mendes, Yluska, Gonçalves Vieira, Martha, Bugarin Steenhouwer, Roselle, Magalhães Pereira Castello Branco, Klebia, Câmara dos Santos, Maria Verônica, Romero Rivera, Ivan, Nicoloso, Luiz Henrique, Palazzi Safadi , Marco Aurelio, Maria de Assis, Dalva
• Tipo de documento: preprint
• Idioma: por
• Título da fonte: SciELO Preprints
• Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/2968
• topic: Infecções por Coronavirus; Pediatria; Síndrome de Resposta Inflamatória Sistêmica; Morte; Monitoramento Epidemiológico; Estudos Transversais; Coronavirus Infections; Pediatrics; Systemic Inflammatory Response; Syndrome; Death; Epidemiological Monitoring; Cross-Sectional Studies

Objective: To describe the clinical-epidemiological profile of Multisystem Inflammatory Syndrome in Children (MIS-C) cases and to identify factors associated with MIS-C deaths in Brazil, 2020. Methods: Cross-sectional study, based on MIS-C national monitoring database in Brazil, 2020. Simple and multiple logistic regression was performed to estimate crude and adjusted odds ratios (OR). Results: The median age of cases (n=652) was 5 years, 57.1% were male, 52.0% were brown race/color and 6.4% died. The odds of death was greater among those who presented O2 saturation <95% (ORa=4.35 – 95%CI 1.69;11.20) and altered result of urea (ORa=5.18 – 95%CI 1.91;14.04); lower in the absence of cutaneous lesion such as rash (ORa=0.23 – 95%CI 0.09;0.62), with the use of anticoagulants (ORa=0.32 – 95%CI 0.12;0.89) and of immunoglobulins (ORa=0.38 – 95%CI 0.15;1.01). Conclusion: Fatality rates was higher among cases that presented O2 saturation<95% and altered urea, and lower among those with cutaneous lesion, who used immunoglobulins and anticoagulants.