COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE

Detalhes bibliográficos
Autor(a) principal: Piedade, Giovanna Santos
Data de Publicação: 2022
Outros Autores: Klas, Cynthia Fontoura, Rebouças, Rebeca Loureiro, Farias, Gleyce Rodrigues da Costa, Guth, Isabelle, Collaço, Luiz Martins, Marques, Camila Moraes, Kubrusly, Luiz Fernando
Tipo de documento: preprint
Idioma: por
Título da fonte: SciELO Preprints
Texto Completo: https://preprints.scielo.org/index.php/scielo/preprint/view/4142
Resumo: Background: Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested. Objective: To evaluate the effect of coconut oil supplementation in cirrhotic rats. Method: Forty Wistars were divided: control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses. Results: AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups. Conclusion: No significant protective effect of coconut oil on liver disease was found.
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spelling COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASEEFEITO DO ÓLEO DE COCO NAS COMPLICAÇÕES DA DOENÇA HEPÁTICACirrose hepáticaExperimentalTioacetamidaÓleo de cocoLiver cirrhosisExperimentalThioacetamideCoconut oilBackground: Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested. Objective: To evaluate the effect of coconut oil supplementation in cirrhotic rats. Method: Forty Wistars were divided: control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses. Results: AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups. Conclusion: No significant protective effect of coconut oil on liver disease was found.Racional: A prevenção da evolução da cirrose com suplementação dietética tem estado em foco óleo de coco tem sido sugerido. Objetivo: Avaliar o efeito da suplementação de óleo de coco em ratos cirróticos. Método: Quarenta Wistar foram divididos: controle (CO); controle + óleo de coco (CO+OC); tioacetamida (TAA) e tioacetamida + óleo de coco (TAA + OC). O TAA foi adicionado à água por 13 semanas e o óleo de coco administrado por gavagem. Amostras de sangue, fígado, tecido muscular e nervoso foram obtidas para análises laboratorial e histopatológica. Resultados: AST, ALT, colesterol total, HDL, LDL, triglicérides não foram estatisticamente significantes. Na histologia, mesmo sem diferenças, houve tendência na significância quanto a proliferação de ductos biliares, septos fibróticos e atrofia da fibra muscular entre os grupos TAA e TAA + OC. Conclusão: Não foi encontrado efeito protetor significativo do óleo de coco na doença hepática.SciELO PreprintsSciELO PreprintsSciELO Preprints2022-05-20info:eu-repo/semantics/preprintinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://preprints.scielo.org/index.php/scielo/preprint/view/414210.1590/SciELOPreprints.4142porhttps://preprints.scielo.org/index.php/scielo/article/view/4142/7841Copyright (c) 2022 Giovanna Santos Piedade, Cynthia Fontoura Klas, Rebeca Loureiro Rebouças, Gleyce Rodrigues da Costa Farias, Isabelle Guth, Luiz Martins Collaço, Camila Moraes Marques, Luiz Fernando Kubruslyhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPiedade, Giovanna SantosKlas, Cynthia FontouraRebouças, Rebeca LoureiroFarias, Gleyce Rodrigues da CostaGuth, IsabelleCollaço, Luiz MartinsMarques, Camila MoraesKubrusly, Luiz Fernandoreponame:SciELO Preprintsinstname:SciELOinstacron:SCI2022-05-20T12:08:37Zoai:ops.preprints.scielo.org:preprint/4142Servidor de preprintshttps://preprints.scielo.org/index.php/scieloONGhttps://preprints.scielo.org/index.php/scielo/oaiscielo.submission@scielo.orgopendoar:2022-05-20T12:08:37SciELO Preprints - SciELOfalse
dc.title.none.fl_str_mv COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
EFEITO DO ÓLEO DE COCO NAS COMPLICAÇÕES DA DOENÇA HEPÁTICA
title COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
spellingShingle COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
Piedade, Giovanna Santos
Cirrose hepática
Experimental
Tioacetamida
Óleo de coco
Liver cirrhosis
Experimental
Thioacetamide
Coconut oil
title_short COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
title_full COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
title_fullStr COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
title_full_unstemmed COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
title_sort COCONUT OIL EFFECT IN THE COMPLICATIONS OF HEPACTIC DISEASE
author Piedade, Giovanna Santos
author_facet Piedade, Giovanna Santos
Klas, Cynthia Fontoura
Rebouças, Rebeca Loureiro
Farias, Gleyce Rodrigues da Costa
Guth, Isabelle
Collaço, Luiz Martins
Marques, Camila Moraes
Kubrusly, Luiz Fernando
author_role author
author2 Klas, Cynthia Fontoura
Rebouças, Rebeca Loureiro
Farias, Gleyce Rodrigues da Costa
Guth, Isabelle
Collaço, Luiz Martins
Marques, Camila Moraes
Kubrusly, Luiz Fernando
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Piedade, Giovanna Santos
Klas, Cynthia Fontoura
Rebouças, Rebeca Loureiro
Farias, Gleyce Rodrigues da Costa
Guth, Isabelle
Collaço, Luiz Martins
Marques, Camila Moraes
Kubrusly, Luiz Fernando
dc.subject.por.fl_str_mv Cirrose hepática
Experimental
Tioacetamida
Óleo de coco
Liver cirrhosis
Experimental
Thioacetamide
Coconut oil
topic Cirrose hepática
Experimental
Tioacetamida
Óleo de coco
Liver cirrhosis
Experimental
Thioacetamide
Coconut oil
description Background: Prevention of the progression of cirrhosis with dietary supplementation has been in focus Coconut oil has been suggested. Objective: To evaluate the effect of coconut oil supplementation in cirrhotic rats. Method: Forty Wistars were divided: control (CO), control + coconut oil (CO + OC), thioacetamide (TAA) and thioacetamide + coconut oil (TAA + OC). TAA was added to water for 13 weeks and coconut oil was administered by gavage. Blood, liver, muscle and nervous tissue samples were obtained for laboratory and histopathological analyses. Results: AST, ALT, total cholesterol, HDL, LDL, triglycerides were not statistically significant. In histology, even without differences, there was a tendency towards significance regarding the proliferation of bile ducts, fibrotic septa and muscle fiber atrophy between the TAA and TAA + OC groups. Conclusion: No significant protective effect of coconut oil on liver disease was found.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/preprint
info:eu-repo/semantics/publishedVersion
format preprint
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://preprints.scielo.org/index.php/scielo/preprint/view/4142
10.1590/SciELOPreprints.4142
url https://preprints.scielo.org/index.php/scielo/preprint/view/4142
identifier_str_mv 10.1590/SciELOPreprints.4142
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://preprints.scielo.org/index.php/scielo/article/view/4142/7841
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
publisher.none.fl_str_mv SciELO Preprints
SciELO Preprints
SciELO Preprints
dc.source.none.fl_str_mv reponame:SciELO Preprints
instname:SciELO
instacron:SCI
instname_str SciELO
instacron_str SCI
institution SCI
reponame_str SciELO Preprints
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repository.name.fl_str_mv SciELO Preprints - SciELO
repository.mail.fl_str_mv scielo.submission@scielo.org
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