Fabrication and Characterization of Gliclazide Loaded Microcapsules

Detalhes bibliográficos
Autor(a) principal: Asad,Muhammad
Data de Publicação: 2014
Outros Autores: Bashir,Sajid, Mahmood,Tariq, Nazir,Imran, Imran,Muhammad, Karim,Sabiha, ul Hassnain,Fakhar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600874
Resumo: This study aimed to formulate, characterize and evaluate the Gliclazide (GLZ) microcapsules prepared with sodium alginate, guar gum and pectin in different ratios by ionotropic-gelation method. The microcapsules were evaluated against different parameters such as particle size and shape, Carr's index, Hausner's ratio, rheological studies and drug release kinetics. Fourier Transform Infra Red (FTIR) and Differential Scanning Calorimetric (DSC) studies demonstrated the absence of any drug - polymers interaction. Promising characteristics were observed in rheological behavior and release kinetics. The size of microcapsules and percentage yield was in the range of 676 to 727 µm and 69 to 77%, respectively. Scanning electron micrographs revealed that microcapsules were discrete, spherical and free flowing. Entrapment efficiency and uniform drug release kinetics were some of the probable characteristics depicting the novel formulation design of Gliclazide microcapsules.
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spelling Fabrication and Characterization of Gliclazide Loaded MicrocapsulesMicrocapsulesgliclazideionotropic-gelation methodguar gumpectinThis study aimed to formulate, characterize and evaluate the Gliclazide (GLZ) microcapsules prepared with sodium alginate, guar gum and pectin in different ratios by ionotropic-gelation method. The microcapsules were evaluated against different parameters such as particle size and shape, Carr's index, Hausner's ratio, rheological studies and drug release kinetics. Fourier Transform Infra Red (FTIR) and Differential Scanning Calorimetric (DSC) studies demonstrated the absence of any drug - polymers interaction. Promising characteristics were observed in rheological behavior and release kinetics. The size of microcapsules and percentage yield was in the range of 676 to 727 µm and 69 to 77%, respectively. Scanning electron micrographs revealed that microcapsules were discrete, spherical and free flowing. Entrapment efficiency and uniform drug release kinetics were some of the probable characteristics depicting the novel formulation design of Gliclazide microcapsules.Instituto de Tecnologia do Paraná - Tecpar2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600874Brazilian Archives of Biology and Technology v.57 n.6 2014reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-8913201402505info:eu-repo/semantics/openAccessAsad,MuhammadBashir,SajidMahmood,TariqNazir,ImranImran,MuhammadKarim,Sabihaul Hassnain,Fakhareng2015-09-03T00:00:00Zoai:scielo:S1516-89132014000600874Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2015-09-03T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Fabrication and Characterization of Gliclazide Loaded Microcapsules
title Fabrication and Characterization of Gliclazide Loaded Microcapsules
spellingShingle Fabrication and Characterization of Gliclazide Loaded Microcapsules
Asad,Muhammad
Microcapsules
gliclazide
ionotropic-gelation method
guar gum
pectin
title_short Fabrication and Characterization of Gliclazide Loaded Microcapsules
title_full Fabrication and Characterization of Gliclazide Loaded Microcapsules
title_fullStr Fabrication and Characterization of Gliclazide Loaded Microcapsules
title_full_unstemmed Fabrication and Characterization of Gliclazide Loaded Microcapsules
title_sort Fabrication and Characterization of Gliclazide Loaded Microcapsules
author Asad,Muhammad
author_facet Asad,Muhammad
Bashir,Sajid
Mahmood,Tariq
Nazir,Imran
Imran,Muhammad
Karim,Sabiha
ul Hassnain,Fakhar
author_role author
author2 Bashir,Sajid
Mahmood,Tariq
Nazir,Imran
Imran,Muhammad
Karim,Sabiha
ul Hassnain,Fakhar
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Asad,Muhammad
Bashir,Sajid
Mahmood,Tariq
Nazir,Imran
Imran,Muhammad
Karim,Sabiha
ul Hassnain,Fakhar
dc.subject.por.fl_str_mv Microcapsules
gliclazide
ionotropic-gelation method
guar gum
pectin
topic Microcapsules
gliclazide
ionotropic-gelation method
guar gum
pectin
description This study aimed to formulate, characterize and evaluate the Gliclazide (GLZ) microcapsules prepared with sodium alginate, guar gum and pectin in different ratios by ionotropic-gelation method. The microcapsules were evaluated against different parameters such as particle size and shape, Carr's index, Hausner's ratio, rheological studies and drug release kinetics. Fourier Transform Infra Red (FTIR) and Differential Scanning Calorimetric (DSC) studies demonstrated the absence of any drug - polymers interaction. Promising characteristics were observed in rheological behavior and release kinetics. The size of microcapsules and percentage yield was in the range of 676 to 727 µm and 69 to 77%, respectively. Scanning electron micrographs revealed that microcapsules were discrete, spherical and free flowing. Entrapment efficiency and uniform drug release kinetics were some of the probable characteristics depicting the novel formulation design of Gliclazide microcapsules.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600874
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600874
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-8913201402505
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.57 n.6 2014
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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