Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Archives of Biology and Technology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033 |
Resumo: | Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity. |
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Brazilian Archives of Biology and Technology |
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Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomysplenectomysodium phytatebiodistributionliverDrugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity.Instituto de Tecnologia do Paraná - Tecpar2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033Brazilian Archives of Biology and Technology v.51 n.spe 2008reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132008000700033info:eu-repo/semantics/openAccessPereira,Kércia Regina Santos GomesAçucena,Maria Kadja Meneses TorresVillarim Neto,ArthurRêgo,Amália Cínthia MenesesBernardo-Filho,MárioAzevedo,Ítalo MedeirosAraújo Filho,IramiMedeiros,Aldo Cunhaeng2009-02-20T00:00:00Zoai:scielo:S1516-89132008000700033Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2009-02-20T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false |
dc.title.none.fl_str_mv |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
title |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
spellingShingle |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy Pereira,Kércia Regina Santos Gomes splenectomy sodium phytate biodistribution liver |
title_short |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
title_full |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
title_fullStr |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
title_full_unstemmed |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
title_sort |
Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy |
author |
Pereira,Kércia Regina Santos Gomes |
author_facet |
Pereira,Kércia Regina Santos Gomes Açucena,Maria Kadja Meneses Torres Villarim Neto,Arthur Rêgo,Amália Cínthia Meneses Bernardo-Filho,Mário Azevedo,Ítalo Medeiros Araújo Filho,Irami Medeiros,Aldo Cunha |
author_role |
author |
author2 |
Açucena,Maria Kadja Meneses Torres Villarim Neto,Arthur Rêgo,Amália Cínthia Meneses Bernardo-Filho,Mário Azevedo,Ítalo Medeiros Araújo Filho,Irami Medeiros,Aldo Cunha |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira,Kércia Regina Santos Gomes Açucena,Maria Kadja Meneses Torres Villarim Neto,Arthur Rêgo,Amália Cínthia Meneses Bernardo-Filho,Mário Azevedo,Ítalo Medeiros Araújo Filho,Irami Medeiros,Aldo Cunha |
dc.subject.por.fl_str_mv |
splenectomy sodium phytate biodistribution liver |
topic |
splenectomy sodium phytate biodistribution liver |
description |
Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02), (p=0.034). ALT, AST and HDL were significantly lower in SP rats (p= 0.001) and leukocytosis was observed in SP rats. In conclusion, splenectomy in rats changed the hepatic biodistribution of Tc-99m-phytate and liver enzimatic activity. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-89132008000700033 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
dc.source.none.fl_str_mv |
Brazilian Archives of Biology and Technology v.51 n.spe 2008 reponame:Brazilian Archives of Biology and Technology instname:Instituto de Tecnologia do Paraná (Tecpar) instacron:TECPAR |
instname_str |
Instituto de Tecnologia do Paraná (Tecpar) |
instacron_str |
TECPAR |
institution |
TECPAR |
reponame_str |
Brazilian Archives of Biology and Technology |
collection |
Brazilian Archives of Biology and Technology |
repository.name.fl_str_mv |
Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar) |
repository.mail.fl_str_mv |
babt@tecpar.br||babt@tecpar.br |
_version_ |
1750318272703627264 |