Antibody conjugate radioimmunotherapy of superficial bladder cancer

Detalhes bibliográficos
Autor(a) principal: Perkins,Alan
Data de Publicação: 2002
Outros Autores: Hopper,Melanie, Murray,Andrea, Frier,Malcolm, Bishop,Mike
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Archives of Biology and Technology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012
Resumo: The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.
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spelling Antibody conjugate radioimmunotherapy of superficial bladder cancerAntibodyradioimmunotherapybladder cancerThe administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.Instituto de Tecnologia do Paraná - Tecpar2002-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012Brazilian Archives of Biology and Technology v.45 n.spe 2002reponame:Brazilian Archives of Biology and Technologyinstname:Instituto de Tecnologia do Paraná (Tecpar)instacron:TECPAR10.1590/S1516-89132002000500012info:eu-repo/semantics/openAccessPerkins,AlanHopper,MelanieMurray,AndreaFrier,MalcolmBishop,Mikeeng2002-10-18T00:00:00Zoai:scielo:S1516-89132002000500012Revistahttps://www.scielo.br/j/babt/https://old.scielo.br/oai/scielo-oai.phpbabt@tecpar.br||babt@tecpar.br1678-43241516-8913opendoar:2002-10-18T00:00Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)false
dc.title.none.fl_str_mv Antibody conjugate radioimmunotherapy of superficial bladder cancer
title Antibody conjugate radioimmunotherapy of superficial bladder cancer
spellingShingle Antibody conjugate radioimmunotherapy of superficial bladder cancer
Perkins,Alan
Antibody
radioimmunotherapy
bladder cancer
title_short Antibody conjugate radioimmunotherapy of superficial bladder cancer
title_full Antibody conjugate radioimmunotherapy of superficial bladder cancer
title_fullStr Antibody conjugate radioimmunotherapy of superficial bladder cancer
title_full_unstemmed Antibody conjugate radioimmunotherapy of superficial bladder cancer
title_sort Antibody conjugate radioimmunotherapy of superficial bladder cancer
author Perkins,Alan
author_facet Perkins,Alan
Hopper,Melanie
Murray,Andrea
Frier,Malcolm
Bishop,Mike
author_role author
author2 Hopper,Melanie
Murray,Andrea
Frier,Malcolm
Bishop,Mike
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Perkins,Alan
Hopper,Melanie
Murray,Andrea
Frier,Malcolm
Bishop,Mike
dc.subject.por.fl_str_mv Antibody
radioimmunotherapy
bladder cancer
topic Antibody
radioimmunotherapy
bladder cancer
description The administration of antibody conjugates for cancer therapy is now proving to be of clinical value. We are currently undertaking a programme of clinical studies using the monoclonal antibody C595 (IgG3) which reacts with the MUC1 glycoprotein antigen that is aberrantly expressed in a high proportion of bladder tumours. Radioimmunoconjugates of the C595 antibody have been produced with high radiolabelling efficiency and immunoreactivity using Tc-99m and In-111 for diagnostic imaging, and disease staging and the cytotoxic radionuclides Cu-67 and Re-188 for therapy of superficial bladder cancer. A Phase I/II therapeutic trail involving the intravesical administration of antibody directly into the bladder has now begun.
publishDate 2002
dc.date.none.fl_str_mv 2002-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-89132002000500012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
publisher.none.fl_str_mv Instituto de Tecnologia do Paraná - Tecpar
dc.source.none.fl_str_mv Brazilian Archives of Biology and Technology v.45 n.spe 2002
reponame:Brazilian Archives of Biology and Technology
instname:Instituto de Tecnologia do Paraná (Tecpar)
instacron:TECPAR
instname_str Instituto de Tecnologia do Paraná (Tecpar)
instacron_str TECPAR
institution TECPAR
reponame_str Brazilian Archives of Biology and Technology
collection Brazilian Archives of Biology and Technology
repository.name.fl_str_mv Brazilian Archives of Biology and Technology - Instituto de Tecnologia do Paraná (Tecpar)
repository.mail.fl_str_mv babt@tecpar.br||babt@tecpar.br
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