Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UCB |
Texto Completo: | http://hdl.handle.net/123456789/172 https://repositorio.ucb.br:9443/jspui/handle/123456789/7489 |
Resumo: | Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of Fst among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations. Am. J. Hum. Biol. 22:187–192, 2010. |
id |
UCB-2_4461d0a53ba16dd72bf7f232715c81a1 |
---|---|
oai_identifier_str |
oai:200.214.135.189:123456789/7489 |
network_acronym_str |
UCB-2 |
network_name_str |
Repositório Institucional da UCB |
spelling |
Lins, Tulio C.Vieira, Rodrigo G.Abreu, Breno Silva deGrattapaglia, DarioPereira, Rinaldo W.2016-10-10T03:51:40Z2016-10-10T03:51:40Z2010-03LINS, Tulio C. et. al. Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs. American Journal of Human Biology, v. 22, p. 187-192, 2010http://hdl.handle.net/123456789/172https://repositorio.ucb.br:9443/jspui/handle/123456789/7489Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of Fst among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations. Am. J. Hum. Biol. 22:187–192, 2010.Made available in DSpace on 2016-10-10T03:51:40Z (GMT). No. of bitstreams: 5 license.txt: 1818 bytes, checksum: 46de3043f08e87659ae535ef74b8ce9d (MD5) Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.pdf: 110113 bytes, checksum: cf9ac91b6b9f8b9bdd94897de84a727f (MD5) license_url: 52 bytes, checksum: 2f32edb9c19a57e928372a33fd08dba5 (MD5) license_text: 22213 bytes, checksum: a03e546c827bdf47d4a06cfce5c2fb1d (MD5) license_rdf: 23692 bytes, checksum: 13c15f5d379f2fc75f816604d123f74e (MD5) Previous issue date: 2010-03SimPublicadoTextoGenetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAmerican journal of human biologyinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UCBinstname:Universidade Católica de Brasília (UCB)instacron:UCBLICENSElicense.txttext/plain1818https://200.214.135.178:9443/jspui/bitstream/123456789/7489/1/license.txt46de3043f08e87659ae535ef74b8ce9dMD51ORIGINALGenetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.pdfapplication/pdf110113https://200.214.135.178:9443/jspui/bitstream/123456789/7489/2/Genetic%20composition%20of%20Brazilian%20population%20samples%20based%20on%20a%20set%20of%20twenty-eight%20ancestry%20informative%20SNPs.pdfcf9ac91b6b9f8b9bdd94897de84a727fMD52CC-LICENSElicense_urlapplication/octet-stream52https://200.214.135.178:9443/jspui/bitstream/123456789/7489/3/license_url2f32edb9c19a57e928372a33fd08dba5MD53license_textapplication/octet-stream22213https://200.214.135.178:9443/jspui/bitstream/123456789/7489/4/license_texta03e546c827bdf47d4a06cfce5c2fb1dMD54license_rdfapplication/octet-stream23692https://200.214.135.178:9443/jspui/bitstream/123456789/7489/5/license_rdf13c15f5d379f2fc75f816604d123f74eMD55TEXTGenetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.pdf.txtGenetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs.pdf.txtExtracted texttext/plain39419https://200.214.135.178:9443/jspui/bitstream/123456789/7489/6/Genetic%20composition%20of%20Brazilian%20population%20samples%20based%20on%20a%20set%20of%20twenty-eight%20ancestry%20informative%20SNPs.pdf.txt13a2bbe388aa8f7d92cb6a8d473b0f4aMD56123456789/74892017-01-17 15:08:08.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ório de Publicaçõeshttps://repositorio.ucb.br:9443/jspui/ |
dc.title.pt_BR.fl_str_mv |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
title |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
spellingShingle |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs Lins, Tulio C. |
title_short |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
title_full |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
title_fullStr |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
title_full_unstemmed |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
title_sort |
Genetic Composition of Brazilian Population Samples Based on a Set of Twenty Eight Ancestry Informative SNPs |
author |
Lins, Tulio C. |
author_facet |
Lins, Tulio C. Vieira, Rodrigo G. Abreu, Breno Silva de Grattapaglia, Dario Pereira, Rinaldo W. |
author_role |
author |
author2 |
Vieira, Rodrigo G. Abreu, Breno Silva de Grattapaglia, Dario Pereira, Rinaldo W. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lins, Tulio C. Vieira, Rodrigo G. Abreu, Breno Silva de Grattapaglia, Dario Pereira, Rinaldo W. |
dc.description.abstract.por.fl_txt_mv |
Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of Fst among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations. Am. J. Hum. Biol. 22:187–192, 2010. |
dc.description.version.pt_BR.fl_txt_mv |
Sim |
dc.description.status.pt_BR.fl_txt_mv |
Publicado |
description |
Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry. Brazilian population is characterized by a genetic background of three parental populations (European, African, and Brazilian Native Amerindians) with a wide degree and diverse patterns of admixture. In this work we analyzed the information content of 28 ancestry-informative SNPs into multiplexed panels using three parental population sources (African, Amerindian, and European) to infer the genetic admixture in an urban sample of the five Brazilian geopolitical regions. The SNPs assigned apart the parental populations from each other and thus can be applied for ancestry estimation in a three hybrid admixed population. Data was used to infer genetic ancestry in Brazilians with an admixture model. Pairwise estimates of Fst among the five Brazilian geopolitical regions suggested little genetic differentiation only between the South and the remaining regions. Estimates of ancestry results are consistent with the heterogeneous genetic profile of Brazilian population, with a major contribution of European ancestry (0.771) followed by African (0.143) and Amerindian contributions (0.085). The described multiplexed SNP panels can be useful tool for bioanthropological studies but it can be mainly valuable to control for spurious results in genetic association studies in admixed populations. Am. J. Hum. Biol. 22:187–192, 2010. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-03 |
dc.date.accessioned.fl_str_mv |
2016-10-10T03:51:40Z |
dc.date.available.fl_str_mv |
2016-10-10T03:51:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
status_str |
publishedVersion |
format |
article |
dc.identifier.citation.fl_str_mv |
LINS, Tulio C. et. al. Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs. American Journal of Human Biology, v. 22, p. 187-192, 2010 |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/123456789/172 https://repositorio.ucb.br:9443/jspui/handle/123456789/7489 |
identifier_str_mv |
LINS, Tulio C. et. al. Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs. American Journal of Human Biology, v. 22, p. 187-192, 2010 |
url |
http://hdl.handle.net/123456789/172 https://repositorio.ucb.br:9443/jspui/handle/123456789/7489 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
Texto |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UCB instname:Universidade Católica de Brasília (UCB) instacron:UCB |
instname_str |
Universidade Católica de Brasília (UCB) |
instacron_str |
UCB |
institution |
UCB |
reponame_str |
Repositório Institucional da UCB |
collection |
Repositório Institucional da UCB |
bitstream.url.fl_str_mv |
https://200.214.135.178:9443/jspui/bitstream/123456789/7489/1/license.txt https://200.214.135.178:9443/jspui/bitstream/123456789/7489/2/Genetic%20composition%20of%20Brazilian%20population%20samples%20based%20on%20a%20set%20of%20twenty-eight%20ancestry%20informative%20SNPs.pdf https://200.214.135.178:9443/jspui/bitstream/123456789/7489/3/license_url https://200.214.135.178:9443/jspui/bitstream/123456789/7489/4/license_text https://200.214.135.178:9443/jspui/bitstream/123456789/7489/5/license_rdf https://200.214.135.178:9443/jspui/bitstream/123456789/7489/6/Genetic%20composition%20of%20Brazilian%20population%20samples%20based%20on%20a%20set%20of%20twenty-eight%20ancestry%20informative%20SNPs.pdf.txt |
bitstream.checksum.fl_str_mv |
46de3043f08e87659ae535ef74b8ce9d cf9ac91b6b9f8b9bdd94897de84a727f 2f32edb9c19a57e928372a33fd08dba5 a03e546c827bdf47d4a06cfce5c2fb1d 13c15f5d379f2fc75f816604d123f74e 13a2bbe388aa8f7d92cb6a8d473b0f4a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1724829828107993088 |