Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise

Detalhes bibliográficos
Autor(a) principal: Soares, Glaydson de Oliveira
Data de Publicação: 2019
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UCB
Texto Completo: https://bdtd.ucb.br:8443/jspui/handle/tede/2720
Resumo: Introduction: The hemodialysis procedure consists of removing the toxic substances, water and minerals from the body through the passage of blood through a filter. During dialysis sessions, loss of carnitine may occur in blood plasma concentrations. Carnitine is considered an important cofactor in intermediate metabolism, since it plays an important role in the biosynthesis and functioning of several other important components of our metabolism. As a result, its decrease in plasma levels in the body may result in changes in energy production, excess of toxic products of fat metabolism, changes in lipid profile and oxidation of fatty acids. Carnitine seems to play an important role in metabolism, especially for patients on dialysis. Objective: To verify the effects of L-carnitine supplementation on lipidogram and hemoglobin in patients submitted to hemodialysis sessions. Materials and methods: Experimental Study, with a random sample of chronic kidney disease patients undergoing hemodialysis in a private clinic in the Federal District. The test was performed in two groups, one experimental and the other placebo. The experimental group ingested L-carnitine, one 0.5 gram (500 mg) capsule, given five times a week, after the hemodialysis procedure, over a period of 12 weeks. Data such as anthropometric measures, biochemical evaluation, 24-hour recall and Physical Activity level were collected both before and after 12 weeks with L-carnitine supplementation. Conclusion: It was concluded that supplementation with L-carnitine did not cause positive changes in hemoglobin, total cholesterol, triglycerides, HDL-c and LDL-c, between the pre and post-intervention periods.
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spelling Rosa, Thiago dos Santoshttp://lattes.cnpq.br/7914454583840134http://lattes.cnpq.br/4261685984194814Soares, Glaydson de Oliveira2020-03-31T21:48:24Z2019-08-30SOARES, Glaydson de Oliveira. Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise. 2019. 64 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2019.https://bdtd.ucb.br:8443/jspui/handle/tede/2720Introduction: The hemodialysis procedure consists of removing the toxic substances, water and minerals from the body through the passage of blood through a filter. During dialysis sessions, loss of carnitine may occur in blood plasma concentrations. Carnitine is considered an important cofactor in intermediate metabolism, since it plays an important role in the biosynthesis and functioning of several other important components of our metabolism. As a result, its decrease in plasma levels in the body may result in changes in energy production, excess of toxic products of fat metabolism, changes in lipid profile and oxidation of fatty acids. Carnitine seems to play an important role in metabolism, especially for patients on dialysis. Objective: To verify the effects of L-carnitine supplementation on lipidogram and hemoglobin in patients submitted to hemodialysis sessions. Materials and methods: Experimental Study, with a random sample of chronic kidney disease patients undergoing hemodialysis in a private clinic in the Federal District. The test was performed in two groups, one experimental and the other placebo. The experimental group ingested L-carnitine, one 0.5 gram (500 mg) capsule, given five times a week, after the hemodialysis procedure, over a period of 12 weeks. Data such as anthropometric measures, biochemical evaluation, 24-hour recall and Physical Activity level were collected both before and after 12 weeks with L-carnitine supplementation. Conclusion: It was concluded that supplementation with L-carnitine did not cause positive changes in hemoglobin, total cholesterol, triglycerides, HDL-c and LDL-c, between the pre and post-intervention periods.Introdu????o: O procedimento de hemodi??lise consiste na retirada das subst??ncias t??xicas, ??gua e sais minerais, do organismo, por meio da passagem do sangue por um filtro. Durante sess??es de di??lise pode ocorrer perda de L-carnitina nas concentra????es do plasma sangu??neo. A L-carnitina ?? considerada um importante cofator no metabolismo intermedi??rio, uma vez que apresenta papel importante na bioss??ntese e funcionamento de diversos outros componentes importantes do nosso metabolismo. Com isso, sua diminui????o plasm??tica no organismo pode ocorrer altera????es na produ????o energ??tica, excesso de produtos t??xicos do metabolismo de gorduras, altera????es no perfil lip??dico e na oxida????o de ??cidos graxos. A L-carnitina parece ter papel importante para o metabolismo, em especial para pacientes em tratamento dial??tico. Objetivo: Verificar os efeitos da suplementa????o com L-carnitina sobre o lipidograma e a hemoglobina em pacientes submetidos a sess??es de hemodi??lise. Materiais e m??todos: Estudo experimental, com amostra aleat??ria de pacientes com doen??a renal cr??nica que realizam hemodi??lise em uma cl??nica particular do Distrito Federal. O procedimento foi realizado em dois grupos, um experimental e o outro placebo. O grupo experimental ingeriu L-carnitina, uma c??psula de 0,5 grama (500 mg), ofertada cinco vezes na semana, ap??s realiza????o do procedimento hemodi??litico, durante um per??odo de 12 semanas. Foram coletadas informa????es como medidas antropom??tricas, avalia????o bioqu??mica, aplica????o do recordat??rio 24 horas e o n??vel de Atividade F??sica, tanto antes quanto ap??s as12 semanas com a suplementa????o de L-carnitina. Conclus??o: Concluiu-se que, a suplementa????o com L-carnitina n??o ocasionou mudan??as positivas nos valores da hemoglobina, colesterol total, triglic??rides, HDL-c e LDL-c, entre o per??odo pr?? e p??s interven????o.Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2020-03-31T21:48:03Z No. of bitstreams: 1 GlaydsondeOliveiraSoaresDissertacao2019.pdf: 2093672 bytes, checksum: f2820bac69c6c27caa6282ab07f5bc60 (MD5)Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2020-03-31T21:48:24Z (GMT) No. of bitstreams: 1 GlaydsondeOliveiraSoaresDissertacao2019.pdf: 2093672 bytes, checksum: f2820bac69c6c27caa6282ab07f5bc60 (MD5)Made available in DSpace on 2020-03-31T21:48:24Z (GMT). No. of bitstreams: 1 GlaydsondeOliveiraSoaresDissertacao2019.pdf: 2093672 bytes, checksum: f2820bac69c6c27caa6282ab07f5bc60 (MD5) Previous issue date: 2019-08-30application/pdfhttps://200.214.135.178:8443/jspui/retrieve/7082/GlaydsondeOliveiraSoaresDissertacao2019.pdf.jpgporUniversidade Cat??lica de Bras??liaPrograma Stricto Sensu em Educa????o F??sicaUCBBrasilEscola de Sa??de e MedicinaHemodi??liseSuplementa????oDoen??a renal cr??nicaChronic kidney diseaseSupplementationHemodialysisCNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICAEfeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??liseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UCBinstname:Universidade Católica de Brasília (UCB)instacron:UCBTHUMBNAILGlaydsondeOliveiraSoaresDissertacao2019.pdf.jpgGlaydsondeOliveiraSoaresDissertacao2019.pdf.jpgimage/jpeg5717https://200.214.135.178:8443/jspui/bitstream/tede/2720/4/GlaydsondeOliveiraSoaresDissertacao2019.pdf.jpgf8c5a20ab5483034e16a76a0b143acb7MD54TEXTGlaydsondeOliveiraSoaresDissertacao2019.pdf.txtGlaydsondeOliveiraSoaresDissertacao2019.pdf.txttext/plain88170https://200.214.135.178:8443/jspui/bitstream/tede/2720/3/GlaydsondeOliveiraSoaresDissertacao2019.pdf.txt62e91fbf8d3ca866c9af7d492c01bd3dMD53LICENSElicense.txtlicense.txttext/plain; charset=utf-81905https://200.214.135.178:8443/jspui/bitstream/tede/2720/1/license.txt75558dcf859532757239878b42f1c2c7MD51ORIGINALGlaydsondeOliveiraSoaresDissertacao2019.pdfGlaydsondeOliveiraSoaresDissertacao2019.pdfapplication/pdf2093672https://200.214.135.178:8443/jspui/bitstream/tede/2720/2/GlaydsondeOliveiraSoaresDissertacao2019.pdff2820bac69c6c27caa6282ab07f5bc60MD52tede/27202020-07-07 15:59:38.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 Digital de Teses e Dissertaçõeshttps://bdtd.ucb.br:8443/jspui/
dc.title.por.fl_str_mv Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
title Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
spellingShingle Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
Soares, Glaydson de Oliveira
Hemodi??lise
Suplementa????o
Doen??a renal cr??nica
Chronic kidney disease
Supplementation
Hemodialysis
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
title_short Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
title_full Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
title_fullStr Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
title_full_unstemmed Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
title_sort Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise
author Soares, Glaydson de Oliveira
author_facet Soares, Glaydson de Oliveira
author_role author
dc.contributor.advisor1.fl_str_mv Rosa, Thiago dos Santos
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7914454583840134
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4261685984194814
dc.contributor.author.fl_str_mv Soares, Glaydson de Oliveira
contributor_str_mv Rosa, Thiago dos Santos
dc.subject.por.fl_str_mv Hemodi??lise
Suplementa????o
Doen??a renal cr??nica
topic Hemodi??lise
Suplementa????o
Doen??a renal cr??nica
Chronic kidney disease
Supplementation
Hemodialysis
CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
dc.subject.eng.fl_str_mv Chronic kidney disease
Supplementation
Hemodialysis
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
dc.description.abstract.eng.fl_txt_mv Introduction: The hemodialysis procedure consists of removing the toxic substances, water and minerals from the body through the passage of blood through a filter. During dialysis sessions, loss of carnitine may occur in blood plasma concentrations. Carnitine is considered an important cofactor in intermediate metabolism, since it plays an important role in the biosynthesis and functioning of several other important components of our metabolism. As a result, its decrease in plasma levels in the body may result in changes in energy production, excess of toxic products of fat metabolism, changes in lipid profile and oxidation of fatty acids. Carnitine seems to play an important role in metabolism, especially for patients on dialysis. Objective: To verify the effects of L-carnitine supplementation on lipidogram and hemoglobin in patients submitted to hemodialysis sessions. Materials and methods: Experimental Study, with a random sample of chronic kidney disease patients undergoing hemodialysis in a private clinic in the Federal District. The test was performed in two groups, one experimental and the other placebo. The experimental group ingested L-carnitine, one 0.5 gram (500 mg) capsule, given five times a week, after the hemodialysis procedure, over a period of 12 weeks. Data such as anthropometric measures, biochemical evaluation, 24-hour recall and Physical Activity level were collected both before and after 12 weeks with L-carnitine supplementation. Conclusion: It was concluded that supplementation with L-carnitine did not cause positive changes in hemoglobin, total cholesterol, triglycerides, HDL-c and LDL-c, between the pre and post-intervention periods.
dc.description.abstract.por.fl_txt_mv Introdu????o: O procedimento de hemodi??lise consiste na retirada das subst??ncias t??xicas, ??gua e sais minerais, do organismo, por meio da passagem do sangue por um filtro. Durante sess??es de di??lise pode ocorrer perda de L-carnitina nas concentra????es do plasma sangu??neo. A L-carnitina ?? considerada um importante cofator no metabolismo intermedi??rio, uma vez que apresenta papel importante na bioss??ntese e funcionamento de diversos outros componentes importantes do nosso metabolismo. Com isso, sua diminui????o plasm??tica no organismo pode ocorrer altera????es na produ????o energ??tica, excesso de produtos t??xicos do metabolismo de gorduras, altera????es no perfil lip??dico e na oxida????o de ??cidos graxos. A L-carnitina parece ter papel importante para o metabolismo, em especial para pacientes em tratamento dial??tico. Objetivo: Verificar os efeitos da suplementa????o com L-carnitina sobre o lipidograma e a hemoglobina em pacientes submetidos a sess??es de hemodi??lise. Materiais e m??todos: Estudo experimental, com amostra aleat??ria de pacientes com doen??a renal cr??nica que realizam hemodi??lise em uma cl??nica particular do Distrito Federal. O procedimento foi realizado em dois grupos, um experimental e o outro placebo. O grupo experimental ingeriu L-carnitina, uma c??psula de 0,5 grama (500 mg), ofertada cinco vezes na semana, ap??s realiza????o do procedimento hemodi??litico, durante um per??odo de 12 semanas. Foram coletadas informa????es como medidas antropom??tricas, avalia????o bioqu??mica, aplica????o do recordat??rio 24 horas e o n??vel de Atividade F??sica, tanto antes quanto ap??s as12 semanas com a suplementa????o de L-carnitina. Conclus??o: Concluiu-se que, a suplementa????o com L-carnitina n??o ocasionou mudan??as positivas nos valores da hemoglobina, colesterol total, triglic??rides, HDL-c e LDL-c, entre o per??odo pr?? e p??s interven????o.
description Introduction: The hemodialysis procedure consists of removing the toxic substances, water and minerals from the body through the passage of blood through a filter. During dialysis sessions, loss of carnitine may occur in blood plasma concentrations. Carnitine is considered an important cofactor in intermediate metabolism, since it plays an important role in the biosynthesis and functioning of several other important components of our metabolism. As a result, its decrease in plasma levels in the body may result in changes in energy production, excess of toxic products of fat metabolism, changes in lipid profile and oxidation of fatty acids. Carnitine seems to play an important role in metabolism, especially for patients on dialysis. Objective: To verify the effects of L-carnitine supplementation on lipidogram and hemoglobin in patients submitted to hemodialysis sessions. Materials and methods: Experimental Study, with a random sample of chronic kidney disease patients undergoing hemodialysis in a private clinic in the Federal District. The test was performed in two groups, one experimental and the other placebo. The experimental group ingested L-carnitine, one 0.5 gram (500 mg) capsule, given five times a week, after the hemodialysis procedure, over a period of 12 weeks. Data such as anthropometric measures, biochemical evaluation, 24-hour recall and Physical Activity level were collected both before and after 12 weeks with L-carnitine supplementation. Conclusion: It was concluded that supplementation with L-carnitine did not cause positive changes in hemoglobin, total cholesterol, triglycerides, HDL-c and LDL-c, between the pre and post-intervention periods.
publishDate 2019
dc.date.issued.fl_str_mv 2019-08-30
dc.date.accessioned.fl_str_mv 2020-03-31T21:48:24Z
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dc.identifier.citation.fl_str_mv SOARES, Glaydson de Oliveira. Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise. 2019. 64 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2019.
dc.identifier.uri.fl_str_mv https://bdtd.ucb.br:8443/jspui/handle/tede/2720
identifier_str_mv SOARES, Glaydson de Oliveira. Efeitos da suplementa????o de L-carnitina sobre o lipidograma e a hemoglobina de pacientes submetidos ?? sess??es de hemodi??lise. 2019. 64 f. Disserta????o (Programa Stricto Sensu em Educa????o F??sica) - Universidade Cat??lica de Bras??lia, Bras??lia, 2019.
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dc.publisher.program.fl_str_mv Programa Stricto Sensu em Educa????o F??sica
dc.publisher.initials.fl_str_mv UCB
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Escola de Sa??de e Medicina
publisher.none.fl_str_mv Universidade Cat??lica de Bras??lia
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