Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/672 |
Resumo: | The Alzheimer’s disease (AD) is a dementia of chronic and progressive nature that causes disturbance in the cognitive functions. Studies indicate that this pathology can be the result of oxidative stress generated in the organism of these individuals. Thus, the present study had as objective to compare the cognitive function, parameters of oxidative and hematological stress in patients with AD and the control group, registered in the Specialized Component of Pharmaceutical Assistance (CEAF), from Guarapuava municipality. 34 patients and 34 controls participated in the study, paring according to gender, age and, at least, one comorbidity. They received home visits for cognitive and socio-demographic evaluation, biochemical and hematological analyses. The cognitive evaluation was carried out using Mini-mental State Examination (MMSE). To evaluate the oxidative stress level, δ-ALA-D, GPx enzymes and vitamin C were dosed through colorimetric methods according to the methodology. For staging the disease, the scale Clinical Demential Rating was used. The sampling studied was comprised of 61.8% (n=21) of female individuals and 38.2% (n=13) of male individuals and their respective controls, with age average of 78.1 ± 8.9 years and median age equal to 80.0 ± 11.0 years. Concerning the physical activity, when comparing DA patients with the control group, there was a statistical difference, showing that the physical activity reduces as the DA level increases. In relation to the existent comorbities, there was no statistical difference when comparing DA patients and their controls. The cognitive function of most of the patients is reduced in the moderate and severe stages of the disease. As for the correlation between enzymes, when comparing patients with AD and the control group, the activity of the enzymes δ-ALA D and GPx have not showed significant difference in the early stage of the disease (CDR1) when dosed in erythrocytes. In the CDR2 and CDR3 stages, lower values were found in the patients with AD (p<0.001). Vitamin C in the three stages of the disease, presented reduced plasma levels for the AD group compared to the control group (p<0.001). We observed that the hematological parameters showed significant variation in the MCV and MCHC of red blood cells and according to the advance of AD, the pro-antioxidant effect of the enzymes δ-ALA D and GPx, and vitamin C is depleted. These results launch the possibility of following these biochemical and hematological parameters in patients with any kind of cognitive decline, aiming at diagnostic as well as prognostic guidance. |
id |
UCEN_2118b016fab54b750f121bc9caaaff12 |
---|---|
oai_identifier_str |
oai:localhost:jspui/672 |
network_acronym_str |
UCEN |
network_name_str |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
repository_id_str |
|
spelling |
Bonini, Juliana Sartorihttp://lattes.cnpq.br/7239838542231670Rocha, João Batista Teixeira dahttp://lattes.cnpq.br/3935055744673018534.580.879-15http://lattes.cnpq.br/4697597382027605HORST, JACQUELINE APARECIDA EIDAM2017-06-06T13:37:07Z2015-08-28HORST, JACQUELINE APARECIDA EIDAM. Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer. 2015. 102 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR.http://tede.unicentro.br:8080/jspui/handle/jspui/672The Alzheimer’s disease (AD) is a dementia of chronic and progressive nature that causes disturbance in the cognitive functions. Studies indicate that this pathology can be the result of oxidative stress generated in the organism of these individuals. Thus, the present study had as objective to compare the cognitive function, parameters of oxidative and hematological stress in patients with AD and the control group, registered in the Specialized Component of Pharmaceutical Assistance (CEAF), from Guarapuava municipality. 34 patients and 34 controls participated in the study, paring according to gender, age and, at least, one comorbidity. They received home visits for cognitive and socio-demographic evaluation, biochemical and hematological analyses. The cognitive evaluation was carried out using Mini-mental State Examination (MMSE). To evaluate the oxidative stress level, δ-ALA-D, GPx enzymes and vitamin C were dosed through colorimetric methods according to the methodology. For staging the disease, the scale Clinical Demential Rating was used. The sampling studied was comprised of 61.8% (n=21) of female individuals and 38.2% (n=13) of male individuals and their respective controls, with age average of 78.1 ± 8.9 years and median age equal to 80.0 ± 11.0 years. Concerning the physical activity, when comparing DA patients with the control group, there was a statistical difference, showing that the physical activity reduces as the DA level increases. In relation to the existent comorbities, there was no statistical difference when comparing DA patients and their controls. The cognitive function of most of the patients is reduced in the moderate and severe stages of the disease. As for the correlation between enzymes, when comparing patients with AD and the control group, the activity of the enzymes δ-ALA D and GPx have not showed significant difference in the early stage of the disease (CDR1) when dosed in erythrocytes. In the CDR2 and CDR3 stages, lower values were found in the patients with AD (p<0.001). Vitamin C in the three stages of the disease, presented reduced plasma levels for the AD group compared to the control group (p<0.001). We observed that the hematological parameters showed significant variation in the MCV and MCHC of red blood cells and according to the advance of AD, the pro-antioxidant effect of the enzymes δ-ALA D and GPx, and vitamin C is depleted. These results launch the possibility of following these biochemical and hematological parameters in patients with any kind of cognitive decline, aiming at diagnostic as well as prognostic guidance.A Doença de Alzheimer (DA) é uma demência de natureza crônica e progressiva que acarreta a perturbação das funções cognitivas. Estudos indicam que esta patologia possa ser decorrente do estresse oxidativo gerado no organismo desses indivíduos. Assim, o presente estudo teve como objetivo comparar a função cognitiva, parâmetros do estresse oxidativo e hematológicos em pacientes com DA, cadastrados no “Componente Especializado da Assistência Farmacêutica (CEAF), do município de Guarapuava, Paraná e grupo controle. Participaram do estudo 34 pacientes e 34 controles,pareando conforme sexo,idade e pelo menos uma comorbidade, aos quais foram realizadas visitas domiciliares para avaliação cognitiva, sócio-demográfica, análise bioquímica e hematológica. A avaliação cognitiva foi realizada com a utilização do Mini Exame do Estado Mental (MEEM). Para a avaliação do nível estresse oxidatvo, as enzimas δ-ALA-D, GPx, e a vitamina C foram dosadas a partir métodos colorimétricos segundo a metodologia. Para o estadiamento da doença utilizou-se a escala Clinical Demential Rating. A amostra estudada foi composta por 61,8% (n=21) do gênero feminino e 38,2% (n=13) do gênero masculino e seus respectivos controles, com média de idade de 78,1 ±8,9 anose mediana igual a 80,0 ± 11,0 anos. Em relação a atividade física comparando-se pacientes com DA e o grupo controle houve diferença estatística, mostrando que a atividade física diminui conforme vai aumentando o estágio da DA.Quanto às comorbidades presentes,não ocorreu nenhuma diferença estatística comparando pacientes DA e seus controles. A função cognitiva da maioria dos pacientes encontra-se diminuída nos estágios moderado e grave da DA. Quanto à correlação entre enzimas, comparando-se pacientes com DA com o grupo controle, a atividade das enzimas δ-ALA D e GPx não apresentou diferença significativa no estágio inicial da doença (CDR1) quando dosadas em eritrócitos. Já nos estágios CDR2 e CDR3 foram obtidos valores menores para os pacientes com DA (p<0,001). A Vitamina C nos três estágios da doença apresentou níveis plasmáticos diminuídos para o grupo DA comparado ao grupo controle (p<0,001). Observamos que os parâmetros hematológicos apresentaram variação significativa nos índices VCM e CHCM das hemácias e que conforme o avanço da DA, o efeito pró-antioxidante das enzimas δ-ALA D e GPx e vitamina C é depletado. Esses resultados lançam a possibilidade de acompanhamento desses parâmetros bioquímicos e hematológicos em pacientes com algum tipo de declínio cognitivo, para fins tanto de auxílio diagnóstico quanto prognóstico.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2017-06-06T13:37:07Z No. of bitstreams: 1 JACQUELINE APARECIDA EIDAM HORST.pdf: 1908742 bytes, checksum: 547bf951451a9c89f2dce57a3fcdc5a3 (MD5)Made available in DSpace on 2017-06-06T13:37:07Z (GMT). No. of bitstreams: 1 JACQUELINE APARECIDA EIDAM HORST.pdf: 1908742 bytes, checksum: 547bf951451a9c89f2dce57a3fcdc5a3 (MD5) Previous issue date: 2015-08-28Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://tede.unicentro.br:8080/jspui/retrieve/2047/JACQUELINE%20APARECIDA%20EIDAM%20HORST.pdf.jpgporUniversidade Estadual do Centro-OestePrograma de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG)UNICENTROBrasilUnicentro::Departamento de FarmáciaEstresse oxidativohemogramaVitamina CGlutationa Peroxidaseδ-ALA Denzimas antioxidantesDoença de Alzheimeroxidative stressCBCvitamin Cglutathione peroxidaseδ-ALA Dantioxidant enzymesAlzheimer’s diseaseCIENCIAS DA SAUDE::FARMACIAAvaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-7679163762264962259600600600600-693476683800971729069976364134497549962075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UNICENTROinstname:Universidade Estadual do Centro-Oeste (UNICENTRO)instacron:UNICENTROLICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://localhost:8080/tede/bitstream/jspui/672/1/license.txtbd3efa91386c1718a7f26a329fdcb468MD51ORIGINALJACQUELINE APARECIDA EIDAM HORST.pdfJACQUELINE APARECIDA EIDAM HORST.pdfapplication/pdf1908742http://localhost:8080/tede/bitstream/jspui/672/2/JACQUELINE+APARECIDA+EIDAM+HORST.pdf547bf951451a9c89f2dce57a3fcdc5a3MD52TEXTJACQUELINE APARECIDA EIDAM HORST.pdf.txtJACQUELINE APARECIDA EIDAM HORST.pdf.txttext/plain129297http://localhost:8080/tede/bitstream/jspui/672/3/JACQUELINE+APARECIDA+EIDAM+HORST.pdf.txt086c67431236b547e0c6d4f7dc0efbe3MD53THUMBNAILJACQUELINE APARECIDA EIDAM HORST.pdf.jpgJACQUELINE APARECIDA EIDAM HORST.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/672/4/JACQUELINE+APARECIDA+EIDAM+HORST.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD54jspui/6722021-03-24 15:22:56.732oai:localhost:jspui/672Tk9UQTogQ09MT1FVRSBBUVVJIEEgU1VBIFBSw5NQUklBIExJQ0VOw4dBCkVzdGEgbGljZW7Dp2EgZGUgZXhlbXBsbyDDqSBmb3JuZWNpZGEgYXBlbmFzIHBhcmEgZmlucyBpbmZvcm1hdGl2b3MuCgpMSUNFTsOHQSBERSBESVNUUklCVUnDh8ODTyBOw4NPLUVYQ0xVU0lWQQoKQ29tIGEgYXByZXNlbnRhw6fDo28gZGVzdGEgbGljZW7Dp2EsIHZvY8OqIChvIGF1dG9yIChlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSDDoCBVbml2ZXJzaWRhZGUgClhYWCAoU2lnbGEgZGEgVW5pdmVyc2lkYWRlKSBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgcmVwcm9kdXppciwgIHRyYWR1emlyIChjb25mb3JtZSBkZWZpbmlkbyBhYmFpeG8pLCBlL291IApkaXN0cmlidWlyIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0csO0bmljbyBlIAplbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mgw6F1ZGlvIG91IHbDrWRlby4KClZvY8OqIGNvbmNvcmRhIHF1ZSBhIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSBwb2RlLCBzZW0gYWx0ZXJhciBvIGNvbnRlw7pkbywgdHJhbnNwb3IgYSBzdWEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvIApwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIHRhbWLDqW0gY29uY29yZGEgcXVlIGEgU2lnbGEgZGUgVW5pdmVyc2lkYWRlIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPDs3BpYSBhIHN1YSB0ZXNlIG91IApkaXNzZXJ0YcOnw6NvIHBhcmEgZmlucyBkZSBzZWd1cmFuw6dhLCBiYWNrLXVwIGUgcHJlc2VydmHDp8Ojby4KClZvY8OqIGRlY2xhcmEgcXVlIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyDDqSBvcmlnaW5hbCBlIHF1ZSB2b2PDqiB0ZW0gbyBwb2RlciBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyAKbmVzdGEgbGljZW7Dp2EuIFZvY8OqIHRhbWLDqW0gZGVjbGFyYSBxdWUgbyBkZXDDs3NpdG8gZGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBuw6NvLCBxdWUgc2VqYSBkZSBzZXUgCmNvbmhlY2ltZW50bywgaW5mcmluZ2UgZGlyZWl0b3MgYXV0b3JhaXMgZGUgbmluZ3XDqW0uCgpDYXNvIGEgc3VhIHRlc2Ugb3UgZGlzc2VydGHDp8OjbyBjb250ZW5oYSBtYXRlcmlhbCBxdWUgdm9jw6ogbsOjbyBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2PDqiAKZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc8OjbyBpcnJlc3RyaXRhIGRvIGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBwYXJhIGNvbmNlZGVyIMOgIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSAKb3MgZGlyZWl0b3MgYXByZXNlbnRhZG9zIG5lc3RhIGxpY2Vuw6dhLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIAppZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250ZcO6ZG8gZGEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFRFU0UgT1UgRElTU0VSVEHDh8ODTyBPUkEgREVQT1NJVEFEQSBURU5IQSBTSURPIFJFU1VMVEFETyBERSBVTSBQQVRST0PDjU5JTyBPVSAKQVBPSU8gREUgVU1BIEFHw4pOQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PIFFVRSBOw4NPIFNFSkEgQSBTSUdMQSBERSAKVU5JVkVSU0lEQURFLCBWT0PDiiBERUNMQVJBIFFVRSBSRVNQRUlUT1UgVE9ET1MgRSBRVUFJU1FVRVIgRElSRUlUT1MgREUgUkVWSVPDg08gQ09NTyAKVEFNQsOJTSBBUyBERU1BSVMgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBPUiBDT05UUkFUTyBPVSBBQ09SRE8uCgpBIFNpZ2xhIGRlIFVuaXZlcnNpZGFkZSBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lIChzKSBvdSBvKHMpIG5vbWUocykgZG8ocykgCmRldGVudG9yKGVzKSBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgZGEgdGVzZSBvdSBkaXNzZXJ0YcOnw6NvLCBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIGFsw6ltIGRhcXVlbGFzIApjb25jZWRpZGFzIHBvciBlc3RhIGxpY2Vuw6dhLgo=Biblioteca Digital de Teses e Dissertaçõeshttp://tede.unicentro.br:8080/jspui/PUBhttp://tede.unicentro.br/tde_oai/oai3.phprepositorio@unicentro.br||fabianoqueiroz@yahoo.com.bropendoar:2021-03-24T18:22:56Biblioteca Digital de Teses e Dissertações do UNICENTRO - Universidade Estadual do Centro-Oeste (UNICENTRO)false |
dc.title.por.fl_str_mv |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
title |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
spellingShingle |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer HORST, JACQUELINE APARECIDA EIDAM Estresse oxidativo hemograma Vitamina C Glutationa Peroxidase δ-ALA D enzimas antioxidantes Doença de Alzheimer oxidative stress CBC vitamin C glutathione peroxidase δ-ALA D antioxidant enzymes Alzheimer’s disease CIENCIAS DA SAUDE::FARMACIA |
title_short |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
title_full |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
title_fullStr |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
title_full_unstemmed |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
title_sort |
Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer |
author |
HORST, JACQUELINE APARECIDA EIDAM |
author_facet |
HORST, JACQUELINE APARECIDA EIDAM |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bonini, Juliana Sartori |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7239838542231670 |
dc.contributor.advisor-co1.fl_str_mv |
Rocha, João Batista Teixeira da |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/3935055744673018 |
dc.contributor.authorID.fl_str_mv |
534.580.879-15 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/4697597382027605 |
dc.contributor.author.fl_str_mv |
HORST, JACQUELINE APARECIDA EIDAM |
contributor_str_mv |
Bonini, Juliana Sartori Rocha, João Batista Teixeira da |
dc.subject.por.fl_str_mv |
Estresse oxidativo hemograma Vitamina C Glutationa Peroxidase δ-ALA D enzimas antioxidantes Doença de Alzheimer |
topic |
Estresse oxidativo hemograma Vitamina C Glutationa Peroxidase δ-ALA D enzimas antioxidantes Doença de Alzheimer oxidative stress CBC vitamin C glutathione peroxidase δ-ALA D antioxidant enzymes Alzheimer’s disease CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
oxidative stress CBC vitamin C glutathione peroxidase δ-ALA D antioxidant enzymes Alzheimer’s disease |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
The Alzheimer’s disease (AD) is a dementia of chronic and progressive nature that causes disturbance in the cognitive functions. Studies indicate that this pathology can be the result of oxidative stress generated in the organism of these individuals. Thus, the present study had as objective to compare the cognitive function, parameters of oxidative and hematological stress in patients with AD and the control group, registered in the Specialized Component of Pharmaceutical Assistance (CEAF), from Guarapuava municipality. 34 patients and 34 controls participated in the study, paring according to gender, age and, at least, one comorbidity. They received home visits for cognitive and socio-demographic evaluation, biochemical and hematological analyses. The cognitive evaluation was carried out using Mini-mental State Examination (MMSE). To evaluate the oxidative stress level, δ-ALA-D, GPx enzymes and vitamin C were dosed through colorimetric methods according to the methodology. For staging the disease, the scale Clinical Demential Rating was used. The sampling studied was comprised of 61.8% (n=21) of female individuals and 38.2% (n=13) of male individuals and their respective controls, with age average of 78.1 ± 8.9 years and median age equal to 80.0 ± 11.0 years. Concerning the physical activity, when comparing DA patients with the control group, there was a statistical difference, showing that the physical activity reduces as the DA level increases. In relation to the existent comorbities, there was no statistical difference when comparing DA patients and their controls. The cognitive function of most of the patients is reduced in the moderate and severe stages of the disease. As for the correlation between enzymes, when comparing patients with AD and the control group, the activity of the enzymes δ-ALA D and GPx have not showed significant difference in the early stage of the disease (CDR1) when dosed in erythrocytes. In the CDR2 and CDR3 stages, lower values were found in the patients with AD (p<0.001). Vitamin C in the three stages of the disease, presented reduced plasma levels for the AD group compared to the control group (p<0.001). We observed that the hematological parameters showed significant variation in the MCV and MCHC of red blood cells and according to the advance of AD, the pro-antioxidant effect of the enzymes δ-ALA D and GPx, and vitamin C is depleted. These results launch the possibility of following these biochemical and hematological parameters in patients with any kind of cognitive decline, aiming at diagnostic as well as prognostic guidance. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-08-28 |
dc.date.accessioned.fl_str_mv |
2017-06-06T13:37:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
HORST, JACQUELINE APARECIDA EIDAM. Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer. 2015. 102 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/672 |
identifier_str_mv |
HORST, JACQUELINE APARECIDA EIDAM. Avaliação de Parâmetros Associados ao Estresse Oxidativo em Pacientes com Doença de Alzheimer. 2015. 102 f. Dissertação (Programa de Pós-Graduação em Ciências Farmacêuticas - Mestrado / Associação Ampla com UEPG) - Universidade Estadual do Centro-Oeste, Guarapuava - PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/672 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-7679163762264962259 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-6934766838009717290 |
dc.relation.cnpq.fl_str_mv |
6997636413449754996 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Farmácia |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UNICENTRO instname:Universidade Estadual do Centro-Oeste (UNICENTRO) instacron:UNICENTRO |
instname_str |
Universidade Estadual do Centro-Oeste (UNICENTRO) |
instacron_str |
UNICENTRO |
institution |
UNICENTRO |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
collection |
Biblioteca Digital de Teses e Dissertações do UNICENTRO |
bitstream.url.fl_str_mv |
http://localhost:8080/tede/bitstream/jspui/672/1/license.txt http://localhost:8080/tede/bitstream/jspui/672/2/JACQUELINE+APARECIDA+EIDAM+HORST.pdf http://localhost:8080/tede/bitstream/jspui/672/3/JACQUELINE+APARECIDA+EIDAM+HORST.pdf.txt http://localhost:8080/tede/bitstream/jspui/672/4/JACQUELINE+APARECIDA+EIDAM+HORST.pdf.jpg |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 547bf951451a9c89f2dce57a3fcdc5a3 086c67431236b547e0c6d4f7dc0efbe3 cc73c4c239a4c332d642ba1e7c7a9fb2 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UNICENTRO - Universidade Estadual do Centro-Oeste (UNICENTRO) |
repository.mail.fl_str_mv |
repositorio@unicentro.br||fabianoqueiroz@yahoo.com.br |
_version_ |
1801859368359034880 |