Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNICENTRO |
Texto Completo: | http://tede.unicentro.br:8080/jspui/handle/jspui/1801 |
Resumo: | The Femoral Head Separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. This condition is closely related to Femoral Head Necrosis (FHN), one of the main locomotor problems that affect the poultry production. Therefore, in this study, a comprehensive analysis identifying shared expression profiles, biological processes (BP) and variants related to FHS and subsequent FHN in chickens was performed through RNA sequencing analysis. To this, two datasets containing 8 normal and 8 FHS-affected transcriptomes from broilers femoral articular cartilage (AC) and growth plate (GP) were analyzed. Furthermore, we have compared the differential gene expression found in FHS-chickens with other datasets available in public databases, trying to clarify shared genes and biological processes related to FHN in different species. A total of 36 differentially expressed (DE) genes were shared between AC and GP tissues, where more than 90% was upregulated in the FHS-affected broilers. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. When the chicken DE genes were compared to other FHN datasets, 8 genes were shared among the evaluated species with normal and FHN affected samples: SLC4A1, EPB42, ANK1, SPTB, CCL26, ADA, SLC25A37 and MKNK2. This study found DE genes between normal and FHS-affected broilers common to both analyzed tissues, showing shared mechanisms involved with this condition in chickens. Comparing the AC and GP DE genes with other datasets related to FHN allowed us to identify genes that are possibly involved with FHN across different species. We were able to find strong candidate genes related to FHS and FHN in chickens, such as SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420. The role of these genes should be more explored in order to validate them as genetic markers to select against FHS/FHN, as well as improving the information available regarding the etiology of these conditions in chickens and possibly in humans. |
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Ibelli, Adriana Mércia Guaratinihttp://lattes.cnpq.br/4729789236742545Peixoto, Jane de Oliveirahttp://lattes.cnpq.br/269361349710661209793686936http://lattes.cnpq.br/8224752884755005Goldoni, Iara2021-11-30T12:46:48Z2021-02-25Goldoni, Iara. Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur. 2021. 65 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR.http://tede.unicentro.br:8080/jspui/handle/jspui/1801The Femoral Head Separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. This condition is closely related to Femoral Head Necrosis (FHN), one of the main locomotor problems that affect the poultry production. Therefore, in this study, a comprehensive analysis identifying shared expression profiles, biological processes (BP) and variants related to FHS and subsequent FHN in chickens was performed through RNA sequencing analysis. To this, two datasets containing 8 normal and 8 FHS-affected transcriptomes from broilers femoral articular cartilage (AC) and growth plate (GP) were analyzed. Furthermore, we have compared the differential gene expression found in FHS-chickens with other datasets available in public databases, trying to clarify shared genes and biological processes related to FHN in different species. A total of 36 differentially expressed (DE) genes were shared between AC and GP tissues, where more than 90% was upregulated in the FHS-affected broilers. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. When the chicken DE genes were compared to other FHN datasets, 8 genes were shared among the evaluated species with normal and FHN affected samples: SLC4A1, EPB42, ANK1, SPTB, CCL26, ADA, SLC25A37 and MKNK2. This study found DE genes between normal and FHS-affected broilers common to both analyzed tissues, showing shared mechanisms involved with this condition in chickens. Comparing the AC and GP DE genes with other datasets related to FHN allowed us to identify genes that are possibly involved with FHN across different species. We were able to find strong candidate genes related to FHS and FHN in chickens, such as SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420. The role of these genes should be more explored in order to validate them as genetic markers to select against FHS/FHN, as well as improving the information available regarding the etiology of these conditions in chickens and possibly in humans.A separação da cabeça femoral (FHS) é geralmente uma condição subclínica caracterizada pelo descolamento da cartilagem articular do osso e é considerada a fase inicial da necrose de cabeça de fêmur (FHN), também conhecida como condronecrose bacteriana com osteomielite (BCO), um dos principais problemas locomotores que afetam a produção avícola. Neste estudo foi realizada uma análise abrangente identificando o perfil de expressão gênica compartilhado entre a cartilagem articular femoral (AC) e a placa de crescimento (GP) da cabeça do fêmur de frangos de corte normais e afetados com FHS aos 35 dias de idade. Processos biológicos e genes comuns entre AC e GP relacionados à FSH foram prospectados por meio da análise de sequenciamento de RNA. Diferindo dos estudos anteriores que investigaram a doença considerando somente o tecido ósseo, aqui foram analisados conjuntamente, dados contendo 8 transcriptomas da AC e a GP de frangos de corte normais e 8 afetados por FHS. Foram identificados 36 genes diferencialmente expressos (DE) entre os grupos normais e afetados por FHS compartilhados entre AC e GP, envolvidos em processos biológicos de transporte de íons e resposta imune relacionados com esta condição. Ao comparar os genes DE comuns com outros conjuntos de dados públicos associados à FHN, foram identificados genes possivelmente envolvidos com a doença em diferentes espécies, como humanos. Neste trabalho, os genes SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 e EPB420 foram considerados possíveis candidatos ao desenvolvimento de FHS/FHN/BCO, contribuindo para a caracterização de processos biológicos e o entendimento da etiologia desta condição.Submitted by Fabiano Jucá (fjuca@unicentro.br) on 2021-11-30T12:46:48Z No. of bitstreams: 1 Dissertação IARA GOLDONI.pdf: 1598936 bytes, checksum: eb5d0885f1b93f9b1868396a8ed00a0d (MD5)Made available in DSpace on 2021-11-30T12:46:48Z (GMT). No. of bitstreams: 1 Dissertação IARA GOLDONI.pdf: 1598936 bytes, checksum: eb5d0885f1b93f9b1868396a8ed00a0d (MD5) Previous issue date: 2021-02-25Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://tede.unicentro.br:8080/jspui/retrieve/7785/Disserta%c3%a7%c3%a3o%20IARA%20GOLDONI.pdf.jpghttp://tede.unicentro.br:8080/jspui/retrieve/7787/Disserta%c3%a7%c3%a3o%20IARA%20GOLDONI.pdf.jpgporUniversidade Estadual do Centro-OestePrograma de Pós-Graduação em Medicina Veterinária (Mestrado)UNICENTROBrasilUnicentro::Departamento de Medicina Veterinárianecrose de cabeça de fêmurRNA-Seqgalinhafemoral head necrosisRNA SeqchickenFHSCIENCIAS AGRARIAS::MEDICINA VETERINARIAComparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmurComparison of articular cartilage and growth plate transcriptomes from normal and femoral head separation affected broilersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis635658161267837813360060060060074005008467382129864536702642350173192075167498588264571info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UNICENTROinstname:Universidade Estadual do Centro-Oeste (UNICENTRO)instacron:UNICENTROTHUMBNAILDissertação IARA GOLDONI.pdf.jpgDissertação IARA GOLDONI.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/1801/4/Disserta%C3%A7%C3%A3o+IARA+GOLDONI.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD54TEXTDissertação IARA GOLDONI.pdf.txtDissertação IARA GOLDONI.pdf.txttext/plain98726http://localhost:8080/tede/bitstream/jspui/1801/3/Disserta%C3%A7%C3%A3o+IARA+GOLDONI.pdf.txtfb18e823ba92eccf6e108474a2c53e13MD53THUMBNAILDissertação IARA GOLDONI.pdf.jpgDissertação IARA GOLDONI.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/jspui/1801/4/Disserta%C3%A7%C3%A3o+IARA+GOLDONI.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD54TEXTDissertação IARA GOLDONI.pdf.txtDissertação IARA GOLDONI.pdf.txttext/plain98726http://localhost:8080/tede/bitstream/jspui/1801/3/Disserta%C3%A7%C3%A3o+IARA+GOLDONI.pdf.txtfb18e823ba92eccf6e108474a2c53e13MD53ORIGINALDissertação IARA GOLDONI.pdfDissertação IARA GOLDONI.pdfapplication/pdf1598936http://localhost:8080/tede/bitstream/jspui/1801/2/Disserta%C3%A7%C3%A3o+IARA+GOLDONI.pdfeb5d0885f1b93f9b1868396a8ed00a0dMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
dc.title.alternative.eng.fl_str_mv |
Comparison of articular cartilage and growth plate transcriptomes from normal and femoral head separation affected broilers |
title |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
spellingShingle |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur Goldoni, Iara necrose de cabeça de fêmur RNA-Seq galinha femoral head necrosis RNA Seq chicken FHS CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
title_full |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
title_fullStr |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
title_full_unstemmed |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
title_sort |
Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur |
author |
Goldoni, Iara |
author_facet |
Goldoni, Iara |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Ibelli, Adriana Mércia Guaratini |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4729789236742545 |
dc.contributor.advisor-co1.fl_str_mv |
Peixoto, Jane de Oliveira |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2693613497106612 |
dc.contributor.authorID.fl_str_mv |
09793686936 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8224752884755005 |
dc.contributor.author.fl_str_mv |
Goldoni, Iara |
contributor_str_mv |
Ibelli, Adriana Mércia Guaratini Peixoto, Jane de Oliveira |
dc.subject.por.fl_str_mv |
necrose de cabeça de fêmur RNA-Seq galinha femoral head necrosis RNA Seq chicken FHS |
topic |
necrose de cabeça de fêmur RNA-Seq galinha femoral head necrosis RNA Seq chicken FHS CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
The Femoral Head Separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. This condition is closely related to Femoral Head Necrosis (FHN), one of the main locomotor problems that affect the poultry production. Therefore, in this study, a comprehensive analysis identifying shared expression profiles, biological processes (BP) and variants related to FHS and subsequent FHN in chickens was performed through RNA sequencing analysis. To this, two datasets containing 8 normal and 8 FHS-affected transcriptomes from broilers femoral articular cartilage (AC) and growth plate (GP) were analyzed. Furthermore, we have compared the differential gene expression found in FHS-chickens with other datasets available in public databases, trying to clarify shared genes and biological processes related to FHN in different species. A total of 36 differentially expressed (DE) genes were shared between AC and GP tissues, where more than 90% was upregulated in the FHS-affected broilers. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. When the chicken DE genes were compared to other FHN datasets, 8 genes were shared among the evaluated species with normal and FHN affected samples: SLC4A1, EPB42, ANK1, SPTB, CCL26, ADA, SLC25A37 and MKNK2. This study found DE genes between normal and FHS-affected broilers common to both analyzed tissues, showing shared mechanisms involved with this condition in chickens. Comparing the AC and GP DE genes with other datasets related to FHN allowed us to identify genes that are possibly involved with FHN across different species. We were able to find strong candidate genes related to FHS and FHN in chickens, such as SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420. The role of these genes should be more explored in order to validate them as genetic markers to select against FHS/FHN, as well as improving the information available regarding the etiology of these conditions in chickens and possibly in humans. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-11-30T12:46:48Z |
dc.date.issued.fl_str_mv |
2021-02-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Goldoni, Iara. Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur. 2021. 65 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
dc.identifier.uri.fl_str_mv |
http://tede.unicentro.br:8080/jspui/handle/jspui/1801 |
identifier_str_mv |
Goldoni, Iara. Comparação dos transcriptomas da cartilagem e da placa de crescimento do fêmur de frangos de corte normais e afetados com necrose de cabeça de fêmur. 2021. 65 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária - Mestrado) - Universidade Estadual do Centro-Oeste, Guarapuava-PR. |
url |
http://tede.unicentro.br:8080/jspui/handle/jspui/1801 |
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por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Estadual do Centro-Oeste |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Medicina Veterinária (Mestrado) |
dc.publisher.initials.fl_str_mv |
UNICENTRO |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Unicentro::Departamento de Medicina Veterinária |
publisher.none.fl_str_mv |
Universidade Estadual do Centro-Oeste |
dc.source.none.fl_str_mv |
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