Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Semina. Ciências Agrárias (Online) |
Texto Completo: | https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40147 |
Resumo: | The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have been described in non human primates, chiropterans, marsupials, rodents, marmots, shrews, and terrestrial hedgehogs. However, the circulation of these viruses in the Amazonian mammal fauna remains unexplored. This study aimed to evaluate the prevalence of antibodies against this hepatovirus in captive and free-living wild mammals belonging to the orders Didelphimorphia, Primates, Carnivora, and Artiodactyla. Serum samples from 71 animals, from three municipalities in the State of Pará (Belém, Santarém, and Capitão-Poço) were tested for total anti-HAV and anti-HAV IgM through enzyme-linked immunosorbent assay (ELISA). Total anti-HAV antibodies were detected in 29.5% (21/71) of non-human primates, 8.4% (6/71) of carnivores, and 5.6% (4/71) of didelphos. All tayassuidos 0% (0/2) were seronegative. Anti-HAV IgM antibodies were not detected in any of the samples tested. The highest total anti-HAV seropositivity in the municipalities studied was in Santarém with 54.24% (12/22), followed by Capitão Poço with 50% (15/30), and then Belém with 21.05% (4/19). Among the seropositive animals, animals kept in exposure cages showed 43.9% (18/41), quarantined animals with 60% (9/15), and free-living animals with 26.6% (4/15). The serological results indicated a profile of previous exposure to hepatovirus among these animals. Therefore, additional studies to characterize HAV-related viruses in captive and free living wild animals need to be conducted to better understand the impact of the circulation of this virus on human and animal health. |
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Semina. Ciências Agrárias (Online) |
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Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, BrazilMarcadores sorológicos para hepatite A entre mamíferos silvestres cativos e de vida livre do Estado do Pará, BrasilAmazonViral hepatitisHepatovirus A.MastofaunaSerology.AmazôniaHepatite viralHepatovirus A.MastofaunaSorologia.The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have been described in non human primates, chiropterans, marsupials, rodents, marmots, shrews, and terrestrial hedgehogs. However, the circulation of these viruses in the Amazonian mammal fauna remains unexplored. This study aimed to evaluate the prevalence of antibodies against this hepatovirus in captive and free-living wild mammals belonging to the orders Didelphimorphia, Primates, Carnivora, and Artiodactyla. Serum samples from 71 animals, from three municipalities in the State of Pará (Belém, Santarém, and Capitão-Poço) were tested for total anti-HAV and anti-HAV IgM through enzyme-linked immunosorbent assay (ELISA). Total anti-HAV antibodies were detected in 29.5% (21/71) of non-human primates, 8.4% (6/71) of carnivores, and 5.6% (4/71) of didelphos. All tayassuidos 0% (0/2) were seronegative. Anti-HAV IgM antibodies were not detected in any of the samples tested. The highest total anti-HAV seropositivity in the municipalities studied was in Santarém with 54.24% (12/22), followed by Capitão Poço with 50% (15/30), and then Belém with 21.05% (4/19). Among the seropositive animals, animals kept in exposure cages showed 43.9% (18/41), quarantined animals with 60% (9/15), and free-living animals with 26.6% (4/15). The serological results indicated a profile of previous exposure to hepatovirus among these animals. Therefore, additional studies to characterize HAV-related viruses in captive and free living wild animals need to be conducted to better understand the impact of the circulation of this virus on human and animal health.O vírus da hepatite A (HAV, Hepatovirus A) em seres humanos apresenta relevante impacto na saúde pública, principalmente em regiões geográficas com saneamento básico deficiente, como a Amazônia brasileira. Isolados relacionados a hepatovírus foram descritos em primatas não humanos, quirópteros, marsupiais, roedores, marmotas, musaranhos e ouriços terrestres, entretanto a circulação destes vírus na mastofauna Amazônia ainda permanece desconhecida. O presente estudo objetivou avaliar a prevalência de anticorpos contra esse hepatovírus, em mamíferos silvestres cativos e de vida livre, pertencentes às ordens Didelphimorphia, Primates, Carnivora e Artiodactyla. Amostras de soro de 71 animais, provenientes de três municípios do Estado do Pará (Belém, Santarém e Capitão-Poço) foram testadas para pesquisa de anti-HAV total e anti-HAV IgM por técnica imunoenzimática (ELISA). Anticorpos anti-HAV total foram detectados em 26,75% (19/71) dos primatas não-humanos, seguido dos felídeos com 11,26% (8/71) e didelphos com 4,24% (3/71), todos os tayassuídes (0/2) foram soronegativos. Anticorpos anti-HAV IgM não foram detectados em nenhuma das amostras testadas. A maior prevalência sorológica para o anti-HAV total ocorreu no município de Santarém (54,24%). E dentre animais soropositivos os mantidos apresentou 43,9% (18/41) dos espécimes, os de quarentena com 56,25% (9/16) e os de vida livre com 21,43% (3/14). Os resultados sorológicos indicaram perfil de exposição pregressa à hepatovírus entre os animais, portanto estudos adicionais para caracterização de vírus relacionados ao HAV em animais silvestres de cativeiro e vida livre precisam ser desenvolvidos para melhor compreensão do impacto da circulação do agente na saúde humana e animal.UEL2021-04-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPesquisa emprírica de Campoapplication/pdfhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/4014710.5433/1679-0359.2021v42n3Supl1p1635Semina: Ciências Agrárias; Vol. 42 No. 3Supl1 (2021); 1635-1646Semina: Ciências Agrárias; v. 42 n. 3Supl1 (2021); 1635-16461679-03591676-546Xreponame:Semina. Ciências Agrárias (Online)instname:Universidade Estadual de Londrina (UEL)instacron:UELenghttps://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40147/29445Copyright (c) 2021 Semina: Ciências Agráriashttp://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessBernal, Marcella Katheryne MarquesSouza, Alex Júnior Souza deNunes, Heloisa MarcelianoMalheiros, Andreza PinheiroChagas, André Antônio Corrêa dasAndrade, Sara Letícia dos SantosFigueiredo, Andréa Lima SilvaCecim, Amanda Desirée AssunçãoPereira, Washington Luiz Assunção2022-09-30T16:05:45Zoai:ojs.pkp.sfu.ca:article/40147Revistahttp://www.uel.br/revistas/uel/index.php/semagrariasPUBhttps://ojs.uel.br/revistas/uel/index.php/semagrarias/oaisemina.agrarias@uel.br1679-03591676-546Xopendoar:2022-09-30T16:05:45Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL)false |
dc.title.none.fl_str_mv |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil Marcadores sorológicos para hepatite A entre mamíferos silvestres cativos e de vida livre do Estado do Pará, Brasil |
title |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
spellingShingle |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil Bernal, Marcella Katheryne Marques Amazon Viral hepatitis Hepatovirus A. Mastofauna Serology. Amazônia Hepatite viral Hepatovirus A. Mastofauna Sorologia. |
title_short |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
title_full |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
title_fullStr |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
title_full_unstemmed |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
title_sort |
Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil |
author |
Bernal, Marcella Katheryne Marques |
author_facet |
Bernal, Marcella Katheryne Marques Souza, Alex Júnior Souza de Nunes, Heloisa Marceliano Malheiros, Andreza Pinheiro Chagas, André Antônio Corrêa das Andrade, Sara Letícia dos Santos Figueiredo, Andréa Lima Silva Cecim, Amanda Desirée Assunção Pereira, Washington Luiz Assunção |
author_role |
author |
author2 |
Souza, Alex Júnior Souza de Nunes, Heloisa Marceliano Malheiros, Andreza Pinheiro Chagas, André Antônio Corrêa das Andrade, Sara Letícia dos Santos Figueiredo, Andréa Lima Silva Cecim, Amanda Desirée Assunção Pereira, Washington Luiz Assunção |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bernal, Marcella Katheryne Marques Souza, Alex Júnior Souza de Nunes, Heloisa Marceliano Malheiros, Andreza Pinheiro Chagas, André Antônio Corrêa das Andrade, Sara Letícia dos Santos Figueiredo, Andréa Lima Silva Cecim, Amanda Desirée Assunção Pereira, Washington Luiz Assunção |
dc.subject.por.fl_str_mv |
Amazon Viral hepatitis Hepatovirus A. Mastofauna Serology. Amazônia Hepatite viral Hepatovirus A. Mastofauna Sorologia. |
topic |
Amazon Viral hepatitis Hepatovirus A. Mastofauna Serology. Amazônia Hepatite viral Hepatovirus A. Mastofauna Sorologia. |
description |
The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have been described in non human primates, chiropterans, marsupials, rodents, marmots, shrews, and terrestrial hedgehogs. However, the circulation of these viruses in the Amazonian mammal fauna remains unexplored. This study aimed to evaluate the prevalence of antibodies against this hepatovirus in captive and free-living wild mammals belonging to the orders Didelphimorphia, Primates, Carnivora, and Artiodactyla. Serum samples from 71 animals, from three municipalities in the State of Pará (Belém, Santarém, and Capitão-Poço) were tested for total anti-HAV and anti-HAV IgM through enzyme-linked immunosorbent assay (ELISA). Total anti-HAV antibodies were detected in 29.5% (21/71) of non-human primates, 8.4% (6/71) of carnivores, and 5.6% (4/71) of didelphos. All tayassuidos 0% (0/2) were seronegative. Anti-HAV IgM antibodies were not detected in any of the samples tested. The highest total anti-HAV seropositivity in the municipalities studied was in Santarém with 54.24% (12/22), followed by Capitão Poço with 50% (15/30), and then Belém with 21.05% (4/19). Among the seropositive animals, animals kept in exposure cages showed 43.9% (18/41), quarantined animals with 60% (9/15), and free-living animals with 26.6% (4/15). The serological results indicated a profile of previous exposure to hepatovirus among these animals. Therefore, additional studies to characterize HAV-related viruses in captive and free living wild animals need to be conducted to better understand the impact of the circulation of this virus on human and animal health. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Pesquisa emprírica de Campo |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40147 10.5433/1679-0359.2021v42n3Supl1p1635 |
url |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40147 |
identifier_str_mv |
10.5433/1679-0359.2021v42n3Supl1p1635 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.uel.br/revistas/uel/index.php/semagrarias/article/view/40147/29445 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Semina: Ciências Agrárias http://creativecommons.org/licenses/by-nc/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
UEL |
publisher.none.fl_str_mv |
UEL |
dc.source.none.fl_str_mv |
Semina: Ciências Agrárias; Vol. 42 No. 3Supl1 (2021); 1635-1646 Semina: Ciências Agrárias; v. 42 n. 3Supl1 (2021); 1635-1646 1679-0359 1676-546X reponame:Semina. Ciências Agrárias (Online) instname:Universidade Estadual de Londrina (UEL) instacron:UEL |
instname_str |
Universidade Estadual de Londrina (UEL) |
instacron_str |
UEL |
institution |
UEL |
reponame_str |
Semina. Ciências Agrárias (Online) |
collection |
Semina. Ciências Agrárias (Online) |
repository.name.fl_str_mv |
Semina. Ciências Agrárias (Online) - Universidade Estadual de Londrina (UEL) |
repository.mail.fl_str_mv |
semina.agrarias@uel.br |
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1799306082912305152 |