Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Acta Scientiarum Biological Sciences |
Texto Completo: | http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791 |
Resumo: | Fumonisins (FBs) are mycotoxins produced by Fusarium molds. Several works have shown contamination of maize by this toxin. Fumonisin B1 (FB-1) is found in greatest proportion (about 70%), resistant to several industrialization processes. In that context, the objective of this work was to analyze the effect of administering a diet contaminated with FB-1 on the morphophysiology of the kidneys of 21-day old male Wistar rats. The animals were divided into 2 groups: G0 (with animals receiving feed free of FBs) and G6 (6mg of FB1 kg-1 of feed). The diet was administered during 42 days. After that period, the animals were placed in metabolic cages for urine collection, blood was collected for analysis of plasma creatinine, and the kidneys were fixed and stained with Masson's trichrome. We observed that FB1 administration did not affect feed intake, body weight gain and animal growth. The normal levels of plasma creatinine suggest that the toxin did not lead to glomerular lesion. There was also no change in water intake, osmolarity and excretion of sodium in urine. However, there was a significant increase in urine volume and potassium excretion in urine, with mild tubulointerstitial changes in the outer cortex for the group receiving the mycotoxin. |
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Effect of administering a diet contamined with fumonisins on the kidneys of wistar ratsnephrotoxicitytubulointerstitial changesmorphophysiology of the kidneysFisiologia RenalFumonisins (FBs) are mycotoxins produced by Fusarium molds. Several works have shown contamination of maize by this toxin. Fumonisin B1 (FB-1) is found in greatest proportion (about 70%), resistant to several industrialization processes. In that context, the objective of this work was to analyze the effect of administering a diet contaminated with FB-1 on the morphophysiology of the kidneys of 21-day old male Wistar rats. The animals were divided into 2 groups: G0 (with animals receiving feed free of FBs) and G6 (6mg of FB1 kg-1 of feed). The diet was administered during 42 days. After that period, the animals were placed in metabolic cages for urine collection, blood was collected for analysis of plasma creatinine, and the kidneys were fixed and stained with Masson's trichrome. We observed that FB1 administration did not affect feed intake, body weight gain and animal growth. The normal levels of plasma creatinine suggest that the toxin did not lead to glomerular lesion. There was also no change in water intake, osmolarity and excretion of sodium in urine. However, there was a significant increase in urine volume and potassium excretion in urine, with mild tubulointerstitial changes in the outer cortex for the group receiving the mycotoxin. Universidade Estadual De Maringá2014-08-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEstudos morfofisiológicos, Estudos da função renalapplication/pdfapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/octet-streamapplication/mswordhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/1979110.4025/actascibiolsci.v36i3.19791Acta Scientiarum. Biological Sciences; Vol 36 No 3 (2014); 333-341Acta Scientiarum. Biological Sciences; v. 36 n. 3 (2014); 333-3411807-863X1679-9283reponame:Acta Scientiarum Biological Sciencesinstname:Universidade Estadual de Maringá (UEM)instacron:UEMengporhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/pdf_27http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142173http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142174http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142175http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142176http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142177http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142178Venancio, Jade CabestreEmerich, Samara SiqueiraBranquinho, Nayra Thaís DelatorreSousa, Fernando Carlos deNatali, Maria Raquel MarçalBaroni, Edmara Aparecidainfo:eu-repo/semantics/openAccess2014-08-20T14:56:00Zoai:periodicos.uem.br/ojs:article/19791Revistahttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSciPUBhttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/oai||actabiol@uem.br1807-863X1679-9283opendoar:2014-08-20T14:56Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
title |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
spellingShingle |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats Venancio, Jade Cabestre nephrotoxicity tubulointerstitial changes morphophysiology of the kidneys Fisiologia Renal |
title_short |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
title_full |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
title_fullStr |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
title_full_unstemmed |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
title_sort |
Effect of administering a diet contamined with fumonisins on the kidneys of wistar rats |
author |
Venancio, Jade Cabestre |
author_facet |
Venancio, Jade Cabestre Emerich, Samara Siqueira Branquinho, Nayra Thaís Delatorre Sousa, Fernando Carlos de Natali, Maria Raquel Marçal Baroni, Edmara Aparecida |
author_role |
author |
author2 |
Emerich, Samara Siqueira Branquinho, Nayra Thaís Delatorre Sousa, Fernando Carlos de Natali, Maria Raquel Marçal Baroni, Edmara Aparecida |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Venancio, Jade Cabestre Emerich, Samara Siqueira Branquinho, Nayra Thaís Delatorre Sousa, Fernando Carlos de Natali, Maria Raquel Marçal Baroni, Edmara Aparecida |
dc.subject.por.fl_str_mv |
nephrotoxicity tubulointerstitial changes morphophysiology of the kidneys Fisiologia Renal |
topic |
nephrotoxicity tubulointerstitial changes morphophysiology of the kidneys Fisiologia Renal |
description |
Fumonisins (FBs) are mycotoxins produced by Fusarium molds. Several works have shown contamination of maize by this toxin. Fumonisin B1 (FB-1) is found in greatest proportion (about 70%), resistant to several industrialization processes. In that context, the objective of this work was to analyze the effect of administering a diet contaminated with FB-1 on the morphophysiology of the kidneys of 21-day old male Wistar rats. The animals were divided into 2 groups: G0 (with animals receiving feed free of FBs) and G6 (6mg of FB1 kg-1 of feed). The diet was administered during 42 days. After that period, the animals were placed in metabolic cages for urine collection, blood was collected for analysis of plasma creatinine, and the kidneys were fixed and stained with Masson's trichrome. We observed that FB1 administration did not affect feed intake, body weight gain and animal growth. The normal levels of plasma creatinine suggest that the toxin did not lead to glomerular lesion. There was also no change in water intake, osmolarity and excretion of sodium in urine. However, there was a significant increase in urine volume and potassium excretion in urine, with mild tubulointerstitial changes in the outer cortex for the group receiving the mycotoxin. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Estudos morfofisiológicos, Estudos da função renal |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791 10.4025/actascibiolsci.v36i3.19791 |
url |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791 |
identifier_str_mv |
10.4025/actascibiolsci.v36i3.19791 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/pdf_27 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142173 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142174 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142175 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142176 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142177 http://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/19791/751375142178 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/octet-stream application/octet-stream application/octet-stream application/octet-stream application/octet-stream application/msword |
dc.publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
publisher.none.fl_str_mv |
Universidade Estadual De Maringá |
dc.source.none.fl_str_mv |
Acta Scientiarum. Biological Sciences; Vol 36 No 3 (2014); 333-341 Acta Scientiarum. Biological Sciences; v. 36 n. 3 (2014); 333-341 1807-863X 1679-9283 reponame:Acta Scientiarum Biological Sciences instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Acta Scientiarum Biological Sciences |
collection |
Acta Scientiarum Biological Sciences |
repository.name.fl_str_mv |
Acta Scientiarum Biological Sciences - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
||actabiol@uem.br |
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1799317395932708864 |