TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Artigo |
Idioma: | eng spa por |
Título da fonte: | Revista de Ciência Veterinária e Saúde Pública |
Texto Completo: | https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497 |
Resumo: | Since December 2019, a new coronavirus species named SARS-CoV-2 has been related to thousands of cases of severe respiratory disease worldwide, been considered a public health issue. Molecular comparisons between isolates from SARS-CoV-2 and other coronavirus species showed identity levels around 79% with the human strain SARS-CoV. However, sequence homology analysis showed that the most closely related known viruses with SARS-CoV-2 are two bat SL-CoVs (~89%), revealing similar evolutionary relationships and evidences that bats can act as reservoirs of SARS-CoV-2. Despite this, viral RNA has been detected in two dogs and two cats belonging to SARS-CoV-2 infected owners, in Hong Kong and Belgium, and in one tiger maintained at the Bronx Zoo in New York City. Additionally, ferrets and cats are found to be highly susceptible to SARS-CoV-2 in an experiment carried out in a controlled environment. However, there is no evidence of these animals acting as reservoirs of the virus. Despite the high genetic identity found among SARS-CoV-2 strains, mutations have been identified, mostly in the structural protein S gene, but until now, there is no enough evidence to relate specific mutation in the viral genome to a higher number of infected patients or death. |
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TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2BatsDogsCatsMolecular analysisSARS-CoV-2Since December 2019, a new coronavirus species named SARS-CoV-2 has been related to thousands of cases of severe respiratory disease worldwide, been considered a public health issue. Molecular comparisons between isolates from SARS-CoV-2 and other coronavirus species showed identity levels around 79% with the human strain SARS-CoV. However, sequence homology analysis showed that the most closely related known viruses with SARS-CoV-2 are two bat SL-CoVs (~89%), revealing similar evolutionary relationships and evidences that bats can act as reservoirs of SARS-CoV-2. Despite this, viral RNA has been detected in two dogs and two cats belonging to SARS-CoV-2 infected owners, in Hong Kong and Belgium, and in one tiger maintained at the Bronx Zoo in New York City. Additionally, ferrets and cats are found to be highly susceptible to SARS-CoV-2 in an experiment carried out in a controlled environment. However, there is no evidence of these animals acting as reservoirs of the virus. Despite the high genetic identity found among SARS-CoV-2 strains, mutations have been identified, mostly in the structural protein S gene, but until now, there is no enough evidence to relate specific mutation in the viral genome to a higher number of infected patients or death.EDUEM - Universidade Estadual de Maringá2020-08-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionavaliado pelos parestextoapplication/pdfapplication/pdfapplication/pdfhttps://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/5549710.4025/revcivet.v7i1.55497Revista de Ciência Veterinária e Saúde Pública; v. 7 n. 1 (2020): V.7 N.1 2020; 043-0482358-4610reponame:Revista de Ciência Veterinária e Saúde Públicainstname:Universidade Estadual de Maringá (UEM)instacron:UEMengspaporhttps://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150659https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150660https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150661Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Públicainfo:eu-repo/semantics/openAccessLetícia Domingues Molinari, Bruna2020-10-15T17:15:56Zoai:periodicos.uem.br/ojs:article/55497Revistahttps://periodicos.uem.br/ojs/index.php/RevCiVet/PUBhttps://periodicos.uem.br/ojs/index.php/RevCiVet/oaipaulomarcusso@gmail.com || periodicos@uem.br2358-46102358-4610opendoar:2020-10-15T17:15:56Revista de Ciência Veterinária e Saúde Pública - Universidade Estadual de Maringá (UEM)false |
dc.title.none.fl_str_mv |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
title |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
spellingShingle |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 Letícia Domingues Molinari, Bruna Bats Dogs Cats Molecular analysis SARS-CoV-2 |
title_short |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
title_full |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
title_fullStr |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
title_full_unstemmed |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
title_sort |
TOPICS ON MOLECULAR CHARACTERIZATION OF THE NOVEL CORONAVIRUS SPECIES SARS-CoV-2 |
author |
Letícia Domingues Molinari, Bruna |
author_facet |
Letícia Domingues Molinari, Bruna |
author_role |
author |
dc.contributor.author.fl_str_mv |
Letícia Domingues Molinari, Bruna |
dc.subject.por.fl_str_mv |
Bats Dogs Cats Molecular analysis SARS-CoV-2 |
topic |
Bats Dogs Cats Molecular analysis SARS-CoV-2 |
description |
Since December 2019, a new coronavirus species named SARS-CoV-2 has been related to thousands of cases of severe respiratory disease worldwide, been considered a public health issue. Molecular comparisons between isolates from SARS-CoV-2 and other coronavirus species showed identity levels around 79% with the human strain SARS-CoV. However, sequence homology analysis showed that the most closely related known viruses with SARS-CoV-2 are two bat SL-CoVs (~89%), revealing similar evolutionary relationships and evidences that bats can act as reservoirs of SARS-CoV-2. Despite this, viral RNA has been detected in two dogs and two cats belonging to SARS-CoV-2 infected owners, in Hong Kong and Belgium, and in one tiger maintained at the Bronx Zoo in New York City. Additionally, ferrets and cats are found to be highly susceptible to SARS-CoV-2 in an experiment carried out in a controlled environment. However, there is no evidence of these animals acting as reservoirs of the virus. Despite the high genetic identity found among SARS-CoV-2 strains, mutations have been identified, mostly in the structural protein S gene, but until now, there is no enough evidence to relate specific mutation in the viral genome to a higher number of infected patients or death. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion avaliado pelos pares texto |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497 10.4025/revcivet.v7i1.55497 |
url |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497 |
identifier_str_mv |
10.4025/revcivet.v7i1.55497 |
dc.language.iso.fl_str_mv |
eng spa por |
language |
eng spa por |
dc.relation.none.fl_str_mv |
https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150659 https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150660 https://periodicos.uem.br/ojs/index.php/RevCiVet/article/view/55497/751375150661 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista de Ciência Veterinária e Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
EDUEM - Universidade Estadual de Maringá |
publisher.none.fl_str_mv |
EDUEM - Universidade Estadual de Maringá |
dc.source.none.fl_str_mv |
Revista de Ciência Veterinária e Saúde Pública; v. 7 n. 1 (2020): V.7 N.1 2020; 043-048 2358-4610 reponame:Revista de Ciência Veterinária e Saúde Pública instname:Universidade Estadual de Maringá (UEM) instacron:UEM |
instname_str |
Universidade Estadual de Maringá (UEM) |
instacron_str |
UEM |
institution |
UEM |
reponame_str |
Revista de Ciência Veterinária e Saúde Pública |
collection |
Revista de Ciência Veterinária e Saúde Pública |
repository.name.fl_str_mv |
Revista de Ciência Veterinária e Saúde Pública - Universidade Estadual de Maringá (UEM) |
repository.mail.fl_str_mv |
paulomarcusso@gmail.com || periodicos@uem.br |
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1754650113781792768 |