O efeito da resistência à insulina sobre a variação do peso e da composição corporal de mulheres submetidas a um programa de intervenção nutricional

• Autor(a) principal: Rocha, Luciana Alonso da
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UERJ
• Texto Completo: http://www.bdtd.uerj.br/handle/1/12765
• topic: Insulin resistance; HOMA; Insulin sensibility; Weight loss; Waist circumference; Waist hip ratio; Body composition; Low glicemic index; Resistência à insulina; HOMA; Sensibilidade à insulina; Perda de peso; Circunferência da cintura; Relação cintura quadril; Composição corporal; Baixo índice glicêmico; CNPQ::CIENCIAS DA SAUDE::SAUDE COLETIVA::EPIDEMIOLOGIA

Morbidity and mortality caused by cardiovascular diseases show a general tendency to decline, but in developing countries, like Brazil, the occurrence of these events is increasing. Obesity and especially the location of intra-abdominal fat, is related to the occurrence of chronic disease and different types of diets have been tested in the search to effective reduction of adiposity. Biological factors such as insulin resistance can interfere with the response obtained with nutritional interventions. The aim of this study was to assess if the weight loss and the changes in the body composition of healthy women, normal weight or overweight, under a program for prevention of weight gain were influenced by the insulin resistance at the beginning of the intervention. This is a prospective observational study. 203 women have been randomly allocated to low and high glycemic index diets. Among these, 185 have been assessed for the presence of insulin resistance at baseline, 34.6% have been classified as insulin resistant according to the HOMA-IR, in the cut value of 2.71. The anthropometric measurements of fat location, waist circumference (WC) and waist hip ratio (WHR) associated with baseline insulin resistance, being the WHR the most strongly associated (prevalence ratio: 2.28, p = 0.0005, while for the WC the value was 1.53, p = 0.04). The analysis of weight modification and anthropometric measurements of body composition throughout the 6 months of follow-up, has not demonstrated statistical significant differences between the groups resistant and non resistant to insulin. In conclusion, although insulin resistance has been correlated to the location of fat mainly measured by waist hip ratio in the beginning of the study, it has not been able to explain changes in body composition and weight in response to a nutritional intervention.