Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13435 |
Resumo: | Texto completo. Acesso restrito. p. 452–459 |
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Poynard, ThierryBruix, JordiSchiff, Eugene R.Diago, MoisesBerg, ThomasMoreno Otero, RicardoLyra, André CastroCarrilho, FlairGriffel, Louis H.Boparai, NavdeepJiang, RuiyunBurroughs, MargaretBrass, Clifford A.Albrecht, Janice K.Poynard, ThierryBruix, JordiSchiff, Eugene R.Diago, MoisesBerg, ThomasMoreno Otero, RicardoLyra, André CastroCarrilho, FlairGriffel, Louis H.Boparai, NavdeepJiang, RuiyunBurroughs, MargaretBrass, Clifford A.Albrecht, Janice K.2013-10-31T18:12:57Z20130168-8278http://repositorio.ufba.br/ri/handle/ri/13435v. 58, n. 3Texto completo. Acesso restrito. p. 452–459Background & Aims: Therapeutic options for patients failing hepatitis C retreatment are limited. EPIC3 included a prospective trial assessing long-term peginterferon alfa-2b (PegIFNa-2b) maintenance therapy in patients with METAVIR fibrosis scores (MFS) of F2 or F3 who previously failed hepatitis C retreatment. Methods: Patients with F2/F3 MFS who failed retreatment were randomized to PegIFNa-2b (0.5 lg/kg/week, n = 270) or observation (n = 270) for 36 months. Blinded liver biopsies obtained before retreatment and after maintenance therapy were evaluated using MFS and activity scores, and confirmatory testing was performed using FibroTest and ActiTest. Results: In total, 348 patients had paired biopsies: 192 patients had missing post-treatment biopsies and were considered as having no change in fibrosis/activity scores. In total, 16% of patients receiving PegIFNa-2b and 11% of observation patients had improvement in MFS (p = 0.32). More PegIFNa-2b than observation patients had improvement in activity score (20% vs. 9%; p <0.001). Among patients treated for >2.5 years, improvement in MFS or activity score was more common with PegIFNa-2b than observation (21% vs. 14%, p = 0.08 and 26% vs. 10%, p <0.001). FibroTest and ActiTest evaluations indicated significant benefit associated with PegIFNa-2b in terms of reduced fibrosis progression and improved activity score. The safety profile of PegIFNa-2b was similar to previous studies. Conclusions: PegIFNa-2b did not significantly improve MFS estimated by biopsy compared with observation; however, activity scores were significantly improved and MFS trended toward increased improvement with treatment durations >2.5 years. Both FibroTest and ActiTest were significantly improved during maintenance therapySubmitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-26T14:51:12Z No. of bitstreams: 1 8888888888888888.pdf: 981828 bytes, checksum: c6bb5c9fcbef5635b34c4c3da779b7c9 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-10-31T18:12:57Z (GMT) No. of bitstreams: 1 8888888888888888.pdf: 981828 bytes, checksum: c6bb5c9fcbef5635b34c4c3da779b7c9 (MD5)Made available in DSpace on 2013-10-31T18:12:57Z (GMT). No. of bitstreams: 1 8888888888888888.pdf: 981828 bytes, checksum: c6bb5c9fcbef5635b34c4c3da779b7c9 (MD5) Previous issue date: 2013SalvadorJournal of Hepatologyhttp://dx.doi.org/10.1016/j.jhep.2012.11.001reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAFibrosisBiomarkersHepatitis CLiverFibroTestImproved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized studyJournal of Hepatologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL8888888888888888.pdf8888888888888888.pdfapplication/pdf981828https://repositorio.ufba.br/bitstream/ri/13435/1/8888888888888888.pdfc6bb5c9fcbef5635b34c4c3da779b7c9MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13435/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT8888888888888888.pdf.txt8888888888888888.pdf.txtExtracted texttext/plain43323https://repositorio.ufba.br/bitstream/ri/13435/3/8888888888888888.pdf.txtf29aad484641b42c7be6df9b86dd3051MD53ri/134352022-07-05 14:03:16.181oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:16Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Hepatology |
| title |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| spellingShingle |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study Poynard, Thierry Fibrosis Biomarkers Hepatitis C Liver FibroTest |
| title_short |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| title_full |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| title_fullStr |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| title_full_unstemmed |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| title_sort |
Improved inflammatory activity with peginterferon alfa-2b maintenance therapy in non-cirrhotic prior non-responders: A randomized study |
| author |
Poynard, Thierry |
| author_facet |
Poynard, Thierry Bruix, Jordi Schiff, Eugene R. Diago, Moises Berg, Thomas Moreno Otero, Ricardo Lyra, André Castro Carrilho, Flair Griffel, Louis H. Boparai, Navdeep Jiang, Ruiyun Burroughs, Margaret Brass, Clifford A. Albrecht, Janice K. |
| author_role |
author |
| author2 |
Bruix, Jordi Schiff, Eugene R. Diago, Moises Berg, Thomas Moreno Otero, Ricardo Lyra, André Castro Carrilho, Flair Griffel, Louis H. Boparai, Navdeep Jiang, Ruiyun Burroughs, Margaret Brass, Clifford A. Albrecht, Janice K. |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Poynard, Thierry Bruix, Jordi Schiff, Eugene R. Diago, Moises Berg, Thomas Moreno Otero, Ricardo Lyra, André Castro Carrilho, Flair Griffel, Louis H. Boparai, Navdeep Jiang, Ruiyun Burroughs, Margaret Brass, Clifford A. Albrecht, Janice K. Poynard, Thierry Bruix, Jordi Schiff, Eugene R. Diago, Moises Berg, Thomas Moreno Otero, Ricardo Lyra, André Castro Carrilho, Flair Griffel, Louis H. Boparai, Navdeep Jiang, Ruiyun Burroughs, Margaret Brass, Clifford A. Albrecht, Janice K. |
| dc.subject.por.fl_str_mv |
Fibrosis Biomarkers Hepatitis C Liver FibroTest |
| topic |
Fibrosis Biomarkers Hepatitis C Liver FibroTest |
| description |
Texto completo. Acesso restrito. p. 452–459 |
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2013 |
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2013-10-31T18:12:57Z |
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2013 |
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info:eu-repo/semantics/publishedVersion |
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0168-8278 |
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v. 58, n. 3 |
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0168-8278 v. 58, n. 3 |
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http://repositorio.ufba.br/ri/handle/ri/13435 |
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openAccess |
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Journal of Hepatology |
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Journal of Hepatology |
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http://dx.doi.org/10.1016/j.jhep.2012.11.001 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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