IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15681 |
Resumo: | Texto completo: acesso restrito. p. 476–486 |
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Cavalcante, Lourianne N.Abe Sandes, KiyokoAngelo, Ana Luiza DiasMachado, Taisa Manuela BonfimLemaire, Denise CarneiroMendes, Carlos Maurício CardealPinho, João Renato RebelloMalta, FernandaLyra, Luiz Guilherme CostaLyra, André CastroCavalcante, Lourianne N.Abe Sandes, KiyokoAngelo, Ana Luiza DiasMachado, Taisa Manuela BonfimLemaire, Denise CarneiroMendes, Carlos Maurício CardealPinho, João Renato RebelloMalta, FernandaLyra, Luiz Guilherme CostaLyra, André Castro2014-08-22T14:49:14Z20121478-3223http://repositorio.ufba.br/ri/handle/ri/15681v. 32, n. 3Texto completo: acesso restrito. p. 476–486Background IL28B polymorphisms are predictors of therapy response in hepatitis C virus (HCV) patients. We do not know whether they are markers of treatment response in admixed populations or not. Aims To determine whether IL28B polymorphisms are predictors of therapy response in patients with HCV from an admixed population and are influenced by genetic ancestry. Methods rs12979860 and rs8099917 were genotyped in 222 HCV patients treated with pegylated interferon and ribavirin. Ancestry was determined using genetic markers. Results IL28B rs12979860 C/C was associated with sustained virological response (SVR), whereas C/T and T/T were associated with failure to therapy (P = 1.12 × 10−5). IL28B rs8099917 T/T was associated with SVR, and G/G and G/T were associated with nonresponse/relapse (NR/R) (P = 8.00 × 10−3). Among HCV genotype 1 patients with C/C genotype, genomic ancestry did not interfere with therapy response. Among patients with rs12979860 T/T genotype, African genetic contribution was greater in the NR/R group (P = 1.51 × 10−3), whereas Amerindian and European genetic ancestry contribution were higher in the SVR group (P = 3.77 × 10−3 and P = 2.16 × 10−2 respectively). Among HCV type 1 patients with rs8099917 T/T, African genetic contribution was significantly greater in the NR/R group (P = 5.0 × 10−3); Amerindian and European ancestry genetic contribution were greater in the SVR group. Conclusion IL28B rs12979860 and rs8099917 polymorphisms were predictors of therapy response in HCV genotypes 1, 2 and 3 subjects from an admixed population. Genomic ancestry did not interfere with response to therapy in patients with rs12979860 C/C, whereas it interfered in patients with C/T and T/T genotypes. Among HCV genotype 1 rs8099917 T/T patients, genomic ancestry interfered with response to therapy.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-19T13:40:07Z No. of bitstreams: 1 Lourianne N. Cavalcante.pdf: 230836 bytes, checksum: 6a5af776161023563ae193168f44a8c2 (MD5)Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2014-08-22T14:49:14Z (GMT) No. of bitstreams: 1 Lourianne N. Cavalcante.pdf: 230836 bytes, checksum: 6a5af776161023563ae193168f44a8c2 (MD5)Made available in DSpace on 2014-08-22T14:49:14Z (GMT). No. of bitstreams: 1 Lourianne N. Cavalcante.pdf: 230836 bytes, checksum: 6a5af776161023563ae193168f44a8c2 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1111/j.1478-3231.2011.02653.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAntiviral therapyGenetic ancestryHepatitis CIL28BPolymorphismSingle nucleotideIL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed populationLiver Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALLourianne N. Cavalcante.pdfLourianne N. 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| dc.title.pt_BR.fl_str_mv |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| dc.title.alternative.pt_BR.fl_str_mv |
Liver International |
| title |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| spellingShingle |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population Cavalcante, Lourianne N. Antiviral therapy Genetic ancestry Hepatitis C IL28B Polymorphism Single nucleotide |
| title_short |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| title_full |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| title_fullStr |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| title_full_unstemmed |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| title_sort |
IL28B polymorphisms are markers of therapy response and are influenced by genetic ancestry in chronic hepatitis C patients from an admixed population |
| author |
Cavalcante, Lourianne N. |
| author_facet |
Cavalcante, Lourianne N. Abe Sandes, Kiyoko Angelo, Ana Luiza Dias Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Mendes, Carlos Maurício Cardeal Pinho, João Renato Rebello Malta, Fernanda Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author_role |
author |
| author2 |
Abe Sandes, Kiyoko Angelo, Ana Luiza Dias Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Mendes, Carlos Maurício Cardeal Pinho, João Renato Rebello Malta, Fernanda Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cavalcante, Lourianne N. Abe Sandes, Kiyoko Angelo, Ana Luiza Dias Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Mendes, Carlos Maurício Cardeal Pinho, João Renato Rebello Malta, Fernanda Lyra, Luiz Guilherme Costa Lyra, André Castro Cavalcante, Lourianne N. Abe Sandes, Kiyoko Angelo, Ana Luiza Dias Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Mendes, Carlos Maurício Cardeal Pinho, João Renato Rebello Malta, Fernanda Lyra, Luiz Guilherme Costa Lyra, André Castro |
| dc.subject.por.fl_str_mv |
Antiviral therapy Genetic ancestry Hepatitis C IL28B Polymorphism Single nucleotide |
| topic |
Antiviral therapy Genetic ancestry Hepatitis C IL28B Polymorphism Single nucleotide |
| description |
Texto completo: acesso restrito. p. 476–486 |
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2012 |
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2012 |
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2014-08-22T14:49:14Z |
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info:eu-repo/semantics/publishedVersion |
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1478-3223 |
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v. 32, n. 3 |
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1478-3223 v. 32, n. 3 |
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http://repositorio.ufba.br/ri/handle/ri/15681 |
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