Control of size in losartan/copper(II) coordination complex hydrophobic precipitate
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14876 |
Resumo: | Texto completo: acesso restrito. p. 3916–3922 |
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Denadai, Ângelo M. L.Silva, Jeferson G. daGuimarães, Pedro P. G.Gomes, Leonardo Bertolini S.Mangrich, Antonio S.Rezende, Edivaltrys I. P. deDaniel, Izabela M. P.Beraldo, HeloísaSinisterra, Rubén D.Denadai, Ângelo M. L.Silva, Jeferson G. daGuimarães, Pedro P. G.Gomes, Leonardo Bertolini S.Mangrich, Antonio S.Rezende, Edivaltrys I. P. deDaniel, Izabela M. P.Beraldo, HeloísaSinisterra, Rubén D.2014-04-29T11:51:20Z20130928-4931http://repositorio.ufba.br/ri/handle/ri/14876v. 33, n. 7Texto completo: acesso restrito. p. 3916–3922Reaction of highly soluble orally active, non-peptide antihypertensive drug losartan with copper(II) leads to the spontaneous formation of a very insoluble 2:1 covalent complex, which self assembles in a hydrophobic supramolecular structure of nanometric dimensions. Thermal analysis showed that Los/Cu(II) complex presents intermediate stability in comparison with its precursors KLos and Cu(OAc)2·H2O. Isothermal titration calorimetry indicated complexation to be a stepwise process, driven by enthalpy and entropy. Zeta potential and DLS measurements showed that it is possible to control the size and charge of nanoprecipitates by adjusting the relative concentration of Los− and Cu(II).Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-29T11:51:20Z No. of bitstreams: 1 1-s2.0-S0928493113003214-main.pdf: 912366 bytes, checksum: 3c5dc5ccd1efea5c05602185d4f5ec2f (MD5)Made available in DSpace on 2014-04-29T11:51:20Z (GMT). No. of bitstreams: 1 1-s2.0-S0928493113003214-main.pdf: 912366 bytes, checksum: 3c5dc5ccd1efea5c05602185d4f5ec2f (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.msec.2013.05.033reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALosartanCopperCoordination complexHydrophobic precipitateStepwise complexationControl of sizeControl of size in losartan/copper(II) coordination complex hydrophobic precipitateMaterials Science and Engineering: Cinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0928493113003214-main.pdf1-s2.0-S0928493113003214-main.pdfapplication/pdf912366https://repositorio.ufba.br/bitstream/ri/14876/1/1-s2.0-S0928493113003214-main.pdf3c5dc5ccd1efea5c05602185d4f5ec2fMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14876/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0928493113003214-main.pdf.txt1-s2.0-S0928493113003214-main.pdf.txtExtracted texttext/plain36513https://repositorio.ufba.br/bitstream/ri/14876/3/1-s2.0-S0928493113003214-main.pdf.txt43bfb298a938c1657aeef71b7f1632a2MD53ri/148762022-07-05 14:04:15.724oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| dc.title.alternative.pt_BR.fl_str_mv |
Materials Science and Engineering: C |
| title |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| spellingShingle |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate Denadai, Ângelo M. L. Losartan Copper Coordination complex Hydrophobic precipitate Stepwise complexation Control of size |
| title_short |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| title_full |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| title_fullStr |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| title_full_unstemmed |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| title_sort |
Control of size in losartan/copper(II) coordination complex hydrophobic precipitate |
| author |
Denadai, Ângelo M. L. |
| author_facet |
Denadai, Ângelo M. L. Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. |
| author_role |
author |
| author2 |
Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Denadai, Ângelo M. L. Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. Denadai, Ângelo M. L. Silva, Jeferson G. da Guimarães, Pedro P. G. Gomes, Leonardo Bertolini S. Mangrich, Antonio S. Rezende, Edivaltrys I. P. de Daniel, Izabela M. P. Beraldo, Heloísa Sinisterra, Rubén D. |
| dc.subject.por.fl_str_mv |
Losartan Copper Coordination complex Hydrophobic precipitate Stepwise complexation Control of size |
| topic |
Losartan Copper Coordination complex Hydrophobic precipitate Stepwise complexation Control of size |
| description |
Texto completo: acesso restrito. p. 3916–3922 |
| publishDate |
2013 |
| dc.date.issued.fl_str_mv |
2013 |
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2014-04-29T11:51:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://repositorio.ufba.br/ri/handle/ri/14876 |
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0928-4931 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 33, n. 7 |
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0928-4931 v. 33, n. 7 |
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http://repositorio.ufba.br/ri/handle/ri/14876 |
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eng |
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http://dx.doi.org/10.1016/j.msec.2013.05.033 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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