Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause

Detalhes bibliográficos
Autor(a) principal: Belo, Najara de Oliveira
Data de Publicação: 2008
Outros Autores: Sairam, M. Ram, Reis, Adelina M. dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6351
Resumo: Acesso restrito: Texto completo. p. 1399-1406
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spelling Belo, Najara de OliveiraSairam, M. RamReis, Adelina M. dosBelo, Najara de OliveiraSairam, M. RamReis, Adelina M. dos2012-07-05T19:44:00Z20080013-7227http://www.repositorio.ufba.br/ri/handle/ri/6351v. 149, n. 3Acesso restrito: Texto completo. p. 1399-1406Estrogen is considered a major regulator of adipose tissue in females. Estrogen increases circulating levels of atrial natriuretic peptide (ANP), a hormone with renal and cardiovascular effects. The aim of this study was to determine the status of the natriuretic peptide system in female follitropin-receptor knockout (FORKO) mice that could be associated with obesity and hypertension observed in these mutants. Furthermore, estradiol treatment was used to reverse alterations observed. FORKO and wild-type (WT) mice received daily injections of estradiol for 4 d. On the fifth day, blood was collected for determination of plasma ANP levels, and selected tissues were collected for determination of ANP, natriuretic peptide receptor type-A (NPR-A) and type-C (NPR-C) gene expression by RT-PCR and binding of [125I]ANP by autoradiography. At 5 months of age, FORKO mice were heavier and had more adipose tissue than WT mice. FORKO mice had lower plasma ANP levels and atrial ANP gene expression and higher renal and adipocyte NPR-C gene expression than WT mice. Estradiol treatment reduced weight gain and increased atrial ANP synthesis as well as decreased ANP clearance NPR-C receptors, resulting in elevation of circulating ANP level. In conclusion, this study shows that FORKO females have an impaired natriuretic peptide system, which may contribute to the susceptibility of FORKO mice to developing age-related hypertension previously shown in these animals. This study establishes a relation between estrogen, adipose tissue, and ANP, which may have important implications in menopausal women.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-07-05T19:44:00Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_4_A2_03BCCd01.pdf: 269316 bytes, checksum: 4d10b3e08015e7703105e3b59b796727 (MD5)Made available in DSpace on 2012-07-05T19:44:00Z (GMT). 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dc.title.pt_BR.fl_str_mv Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
dc.title.alternative.pt_BR.fl_str_mv ENDOCRINOLOGY
title Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
spellingShingle Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
Belo, Najara de Oliveira
title_short Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
title_full Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
title_fullStr Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
title_full_unstemmed Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
title_sort Impairment of the Natriuretic Peptide System in Follitropin Receptor Knockout Mice and Reversal by Estradiol: Implications for Obesity-Associated Hypertension in Menopause
author Belo, Najara de Oliveira
author_facet Belo, Najara de Oliveira
Sairam, M. Ram
Reis, Adelina M. dos
author_role author
author2 Sairam, M. Ram
Reis, Adelina M. dos
author2_role author
author
dc.contributor.author.fl_str_mv Belo, Najara de Oliveira
Sairam, M. Ram
Reis, Adelina M. dos
Belo, Najara de Oliveira
Sairam, M. Ram
Reis, Adelina M. dos
description Acesso restrito: Texto completo. p. 1399-1406
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-07-05T19:44:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6351
dc.identifier.issn.none.fl_str_mv 0013-7227
dc.identifier.number.pt_BR.fl_str_mv v. 149, n. 3
identifier_str_mv 0013-7227
v. 149, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/6351
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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