Short communication: use of raltegravir in late-presenting HIV-infected pregnant women

Detalhes bibliográficos
Autor(a) principal: Nóbrega, Isabella
Data de Publicação: 2013
Outros Autores: Travassos, Ana Gabriela Álvares, Haguihara, Tatiana, Amorim, Fábio Alan Carqueija, Brites, Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16015
Resumo: Texto completo: acesso restrito. p. 1451-1454
id UFBA-2_2ea5a2226528282caccd4a9d49a96312
oai_identifier_str oai:repositorio.ufba.br:ri/16015
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Nóbrega, IsabellaTravassos, Ana Gabriela ÁlvaresHaguihara, TatianaAmorim, Fábio Alan CarqueijaBrites, CarlosNóbrega, IsabellaTravassos, Ana Gabriela ÁlvaresHaguihara, TatianaAmorim, Fábio Alan CarqueijaBrites, Carlos2014-09-09T16:15:54Z20130889-2229http://repositorio.ufba.br/ri/handle/ri/16015v. 29, n. 11Texto completo: acesso restrito. p. 1451-1454The risk of HIV-1 mother-to-child transmission (MTCT) is clearly correlated with the maternal HIV cell-free viral load (VL) at delivery. Preventing MTCT in late-presenting (after 28 weeks) HIV-infected pregnant women remains a clinical challenge, and ensuring a rapid decrease of maternal VL is an important preventive strategy. Raltegravir (RGV) has a higher first and second phase viral decay rate, has a high placental transfer, with a potential preloading effect for neonate, and demonstrates effective accumulation in cervicovaginal secretions. We report 14 cases in which RGV was used late in pregnancy for HIV-1 MTCT prophylaxis. All women were RGV naive and the prophylaxis regimens included RGV plus at least two other antiretroviral agents. At RGV initiation, the median gestational age was 36 weeks (range 34–38) and the median maternal plasma HIV-1 RNA viral load was 35,364 copies/ml (range 636–391,535). At delivery, the median gestational age was 38 weeks (range 37–40). The median exposure time to RGV was 17 days (range 7–32), with a mean maternal VL decay of 2.6 log. At delivery, seven women had undetectable (<50 copies/ml) VL, four had between 64 and 457 copies/ml, and in three VL was not available. All but one infant's HIV-RNA tests were negative at 1 and 3 months (one case of in utero MTCT). Raltegravir-containing antiretroviral regimens induced a rapid HIV-RNA decline in maternal VL at delivery, and were safe and effective in preventing MTCT for late-presenting, HIV-infected women.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-08T13:49:23Z No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:15:54Z (GMT) No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5)Made available in DSpace on 2014-09-09T16:15:54Z (GMT). No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5) Previous issue date: 2013http://dx.doi.org/10.1089/aid.2013.0059.reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAShort communication: use of raltegravir in late-presenting HIV-infected pregnant womenAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALaid%2E2013%2E0059.pdfaid%2E2013%2E0059.pdfapplication/pdf94680https://repositorio.ufba.br/bitstream/ri/16015/1/aid%252E2013%252E0059.pdf9f988c817cdf659da97cb61ed675c7fbMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16015/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTaid%2E2013%2E0059.pdf.txtaid%2E2013%2E0059.pdf.txtExtracted texttext/plain18967https://repositorio.ufba.br/bitstream/ri/16015/3/aid%252E2013%252E0059.pdf.txt0810eae75cc974f57dfd765e6f36e907MD53ri/160152022-07-05 14:03:07.794oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:07Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
spellingShingle Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
Nóbrega, Isabella
title_short Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
title_full Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
title_fullStr Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
title_full_unstemmed Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
title_sort Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
author Nóbrega, Isabella
author_facet Nóbrega, Isabella
Travassos, Ana Gabriela Álvares
Haguihara, Tatiana
Amorim, Fábio Alan Carqueija
Brites, Carlos
author_role author
author2 Travassos, Ana Gabriela Álvares
Haguihara, Tatiana
Amorim, Fábio Alan Carqueija
Brites, Carlos
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nóbrega, Isabella
Travassos, Ana Gabriela Álvares
Haguihara, Tatiana
Amorim, Fábio Alan Carqueija
Brites, Carlos
Nóbrega, Isabella
Travassos, Ana Gabriela Álvares
Haguihara, Tatiana
Amorim, Fábio Alan Carqueija
Brites, Carlos
description Texto completo: acesso restrito. p. 1451-1454
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-09T16:15:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16015
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v. 29, n. 11
identifier_str_mv 0889-2229
v. 29, n. 11
url http://repositorio.ufba.br/ri/handle/ri/16015
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1089/aid.2013.0059.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/16015/1/aid%252E2013%252E0059.pdf
https://repositorio.ufba.br/bitstream/ri/16015/2/license.txt
https://repositorio.ufba.br/bitstream/ri/16015/3/aid%252E2013%252E0059.pdf.txt
bitstream.checksum.fl_str_mv 9f988c817cdf659da97cb61ed675c7fb
0d4b811ef71182510d2015daa7c8a900
0810eae75cc974f57dfd765e6f36e907
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459475244285952

Registros relacionados