Short communication: use of raltegravir in late-presenting HIV-infected pregnant women
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16015 |
Resumo: | Texto completo: acesso restrito. p. 1451-1454 |
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Nóbrega, IsabellaTravassos, Ana Gabriela ÁlvaresHaguihara, TatianaAmorim, Fábio Alan CarqueijaBrites, CarlosNóbrega, IsabellaTravassos, Ana Gabriela ÁlvaresHaguihara, TatianaAmorim, Fábio Alan CarqueijaBrites, Carlos2014-09-09T16:15:54Z20130889-2229http://repositorio.ufba.br/ri/handle/ri/16015v. 29, n. 11Texto completo: acesso restrito. p. 1451-1454The risk of HIV-1 mother-to-child transmission (MTCT) is clearly correlated with the maternal HIV cell-free viral load (VL) at delivery. Preventing MTCT in late-presenting (after 28 weeks) HIV-infected pregnant women remains a clinical challenge, and ensuring a rapid decrease of maternal VL is an important preventive strategy. Raltegravir (RGV) has a higher first and second phase viral decay rate, has a high placental transfer, with a potential preloading effect for neonate, and demonstrates effective accumulation in cervicovaginal secretions. We report 14 cases in which RGV was used late in pregnancy for HIV-1 MTCT prophylaxis. All women were RGV naive and the prophylaxis regimens included RGV plus at least two other antiretroviral agents. At RGV initiation, the median gestational age was 36 weeks (range 34–38) and the median maternal plasma HIV-1 RNA viral load was 35,364 copies/ml (range 636–391,535). At delivery, the median gestational age was 38 weeks (range 37–40). The median exposure time to RGV was 17 days (range 7–32), with a mean maternal VL decay of 2.6 log. At delivery, seven women had undetectable (<50 copies/ml) VL, four had between 64 and 457 copies/ml, and in three VL was not available. All but one infant's HIV-RNA tests were negative at 1 and 3 months (one case of in utero MTCT). Raltegravir-containing antiretroviral regimens induced a rapid HIV-RNA decline in maternal VL at delivery, and were safe and effective in preventing MTCT for late-presenting, HIV-infected women.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-08T13:49:23Z No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:15:54Z (GMT) No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5)Made available in DSpace on 2014-09-09T16:15:54Z (GMT). No. of bitstreams: 1 aid%2E2013%2E0059.pdf: 94680 bytes, checksum: 9f988c817cdf659da97cb61ed675c7fb (MD5) Previous issue date: 2013http://dx.doi.org/10.1089/aid.2013.0059.reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAShort communication: use of raltegravir in late-presenting HIV-infected pregnant womenAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALaid%2E2013%2E0059.pdfaid%2E2013%2E0059.pdfapplication/pdf94680https://repositorio.ufba.br/bitstream/ri/16015/1/aid%252E2013%252E0059.pdf9f988c817cdf659da97cb61ed675c7fbMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16015/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTaid%2E2013%2E0059.pdf.txtaid%2E2013%2E0059.pdf.txtExtracted texttext/plain18967https://repositorio.ufba.br/bitstream/ri/16015/3/aid%252E2013%252E0059.pdf.txt0810eae75cc974f57dfd765e6f36e907MD53ri/160152022-07-05 14:03:07.794oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:07Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
dc.title.alternative.pt_BR.fl_str_mv |
AIDS Research and Human Retroviruses |
title |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
spellingShingle |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women Nóbrega, Isabella |
title_short |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
title_full |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
title_fullStr |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
title_full_unstemmed |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
title_sort |
Short communication: use of raltegravir in late-presenting HIV-infected pregnant women |
author |
Nóbrega, Isabella |
author_facet |
Nóbrega, Isabella Travassos, Ana Gabriela Álvares Haguihara, Tatiana Amorim, Fábio Alan Carqueija Brites, Carlos |
author_role |
author |
author2 |
Travassos, Ana Gabriela Álvares Haguihara, Tatiana Amorim, Fábio Alan Carqueija Brites, Carlos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nóbrega, Isabella Travassos, Ana Gabriela Álvares Haguihara, Tatiana Amorim, Fábio Alan Carqueija Brites, Carlos Nóbrega, Isabella Travassos, Ana Gabriela Álvares Haguihara, Tatiana Amorim, Fábio Alan Carqueija Brites, Carlos |
description |
Texto completo: acesso restrito. p. 1451-1454 |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-09-09T16:15:54Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/16015 |
dc.identifier.issn.none.fl_str_mv |
0889-2229 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 29, n. 11 |
identifier_str_mv |
0889-2229 v. 29, n. 11 |
url |
http://repositorio.ufba.br/ri/handle/ri/16015 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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openAccess |
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http://dx.doi.org/10.1089/aid.2013.0059. |
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